#1

Hi, I’m new here and only recently learned of rapamycin.

I read some recent articles reviewing it’s affects on increasing fertility and delaying menopause in female trial patients, which brought me to look more closely into it.

I’ve read through a number of the threads here already, and it seems most of the information here is focused on longevity and increasing lifespan, but my interest is in increasing healthspan from an already compromised position.

From what I’ve read, it appears to improve mitochondrial function, which has been implicated as a contributing factor in CFS/ME.

There also appear to be benefits involving T-cells and mast cells from the use of rapamycin. (I’ll try to link any of the studies I’ve found on this).

I started metformin recently, as a potential treatment for “menstrual issues” not directly related to PCOS, and the change so far has been remarkable, the greatest of which was it’s ability to reduce my unfathomably high IgE (which I didn’t even learn about until after I began taking it).

I had read about metformin and rapamycin’s synergistic effects, and my doctor, not entirely familiar with rapamycin, had decided to start me on metformin. I have a follow-up visit next week, and plan to request the baseline tests listed in the getting started thread, then request a prescription for rapamycin.

In my reading here, I caught mention of polycystic kidney disease (which I have, identified by MRI) though it’s asymptomatic and labs are good. I also have multiple food allergies, autoimmunity, migraines, cystic ovaries, and likely MCAS and autism spectrum.

I have struggled with chronic low-grade infections in the past (sinusitis, bronchitis, ear infections, and UTIs) which is certainly a concern with this drug. And I used to suffer from canker sores regularly before starting a regimen of daily rinsing with hydrogen peroxide, which has eliminated them.

If anyone has information about benefits or contradictions of rapamycin involving any of these conditions, or recommendations on ‘best practices’ when it comes to introducing it from an already compromised health perspective, I’d appreciate any input.

https://onlinelibrary.wiley.com/doi/10.1155/2022/9534163

https://onlinelibrary.wiley.com/doi/10.1111/all.12000

https://portlandpress.com/bioscirep/article/37/4/BSR20170767/57234/Rapamycin-alleviates-inflammation-and-muscle

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#2

I won’t comment on rapamycin/metformin but rather on Polycystic Kidney Disease.

Just thought I’d give you a heads-up that there is an Aussie company that is developing an RNA treatment for this. It’s still in pre-clinical development but they will be doing healthy volunteers (Phase 1) maybe Q1-2 next year and Phase 2 maybe this time next year. So you might be eligible to enroll in that.
The company is PYC Therapeutics. It’s based in Perth, Australia but also in San Francisco.

Full Disclosure: I own shares in PYC.

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#3

Thanks for the suggestion, and disclosure!

I’m in the US, in Iowa. Will the trial be in Australia, or are they planning to branch out from their San Francisco headquarters as well, and if so, how far would trial participants need to travel? Or are these all questions for them directly, once phase II opens?

#4

Hi Andrea,

As far as I know at least part of the trial will be taking part in the USA. I understand that Phases 2-3 are likely to be done by a big-pharma licensee as it would be just too big for PYC. That would mean it would almost certainly be done in the USA.
I’m not sure when they will be recruiting for Phase 2 but I recommend that you reach out to PYC, certainly no later than when Phase 1 has concluded.
Best regards,
DrT

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