Rapamycin and Reynaud’s?

PNW · 2024-01-24T14:45:32.536Z

Has anyone out there noticed an improvement in Reynauds symptoms since starting rapa?

L_H · 2024-01-24T15:36:56.028Z

V interested in this, because it would make sense that rapa would help. Here’s a case study in someone with the scleroderma (which is related? to reynaud’s)

PubMed Central (PMC)

Efficacy of Rapamycin in Scleroderma: A Case Study

Scleroderma is a common autoimmune disorder with no effective therapy. Current concepts of scleroderma include the hypothesis that scleroderma results from excess conversion of endothelial cells to fibroblast like cells, called endothelial...

Stiv · 2024-01-24T19:08:10.306Z

It is an n=1 account but Ive not had an attack in two years. On Rapa 6-8mg weekly. I upped other supplements and nitrate intake for vasodilation so hard to tell but it might be a contributing factor

PNW · 2024-01-25T02:42:53.564Z

Curious how many episodes you were having before starting the rapa (and doing the other things)?

Stiv · 2024-01-25T10:41:10.513Z

Used to have about two episodes a year, usually in colder seasons. So not too bad. But this discussion reminded me that it hasn’t happened for a while.
Ive got genes for ASCVD so I do other stuff to reduce my plaque burden and maintain vasodilation eg nattokinase, aspirin etc so hard to know what the contribution of Rapamycin is.