#2074

The question should be “when”: When will they have an event. No doubt they will have it, but not clear when. Depending on life style and genetics it could be sooner or later. May be it’s not even significant to know.

1 Like
#2075

CVD is the leading cause of death but I’ve heard Kaeberlein say that eliminating CVD would only add a few years to average lifespan because everyone dies of something. But it’s worth addressing the big ones first. The longer you plan to live, the earlier this should be dealt with. I’m playing catch-up because I was foolish.

2 Likes
#2076

Eliminating ASVCD would only a few years to the average life expectacy because cancer and dementia still exist. Eliminating all three would easily increase the average life expectacy to 100 or so.

2 Likes
#2077

To the question “and then what?”

If asymptomatic patients have “normal” but suboptimal lab tests, is that something that should even be brought up by the family physician? What if the patient brings it up? Is the optimization of health in “healthy” patients a service that many physicians are prepared to offer?

I would think that growing demand for longevity medicine by those who are willing to pay for it will dictate the answer to “and then what?”

Should it be otherwise?

1 Like
#2078

I don’t know how many will go on to develop CVD, but in the United States, someone dies of it every 30 seconds. It is the leading cause of death.

1 Like
#2079

Yes, but as ASCVD is very complex disease. I had the time yesterday evening to read this study @AnUser shared. It is important to note that most participants had one or several risk factors. So it is important to keep an eye on all risk factors, not just lipids. IMO this is primarily a metabolic disease and all metabolic risk factors should be taken care to avoid major ASCVD events.

1 Like
#2080

Excellent discussion here guys. Thanks for all of your well thought out ideas.

1 Like
#2081

In my opinion, you can reduce your risk of ASVCD by 80% just by keeping lipids and blood pressure down. The other 20% are risk factors like inflammation, diabetes, smoking, obesity etc.

1 Like
#2082

It could be easy to do if everything (lipids, BP, diabetes, inflammation, obesity, etc) were not interconnected.

2 Likes
#2083

So hard to tell these days.

#2084

Lumbrokinase and its many applications.

In this study, we innovatively propose two proteins extracted from earthworms, lumbrokinase (LRK) and earthworm protein (EP), as potent modifiers of calcium oxalate (CaOx) crystals.

1 Like
#2085

Is Vascepa (icosapent ethyl) a prescription omega-3 fatty acid still a good option for lowering triglycerides? @PL_Brooklyn_NY

Screenshot 2023-08-15 at 9.19.33 PM
Screenshot 2023-08-15 at 9.19.33 PM1834×536 50.1 KB

Peter Attia: A new analysis of REDUCE-IT: benefits of omega-3s vs. harm from placebos

2 Likes
#2086

I think we should avoid to ask @PL_Brooklyn_NY too many questions, their time is probably very limited and we can do our own research for many questions. Welcome to the forum to read/comment/respond what you feel is important not based on what people ask you.

1 Like
#2087

1+ MONTH ROSUVASTATIN UPDATE

I just tested my apoB after 1+ month of rosuvastatin 5 mg…
And it was 59 mg/dl. It has gone UP 4 mg/dl.
I have (1) stopped using canola oil much, and (2) berberine, since last check.
Very unfortunate result. Maybe statins don’t work so well in lower apoB’s… they are tested with hypercholestrolemia.

2022 Jan -
72 mg/dl ApoB

2022 Oct -
55 mg/dl ApoB
<10 nmol/L Lp(a)

2023 Aug -
59 mg/dl ApoB

I am also throwing olive oil in the trash can.

2 Likes
#2088

Just to be clear I am continuing Crestor 5 mg/day a few more months.
I am stopping OLIVE OIL completely! NO OLIVE OIL!
Instead I am going to be using canola oil which improves lipids better than it…

If 5 mg/day + canola oil doesn’t work I am probably have to think about using PCSK9 inhibitor instead… I’ll have to eat the cost which would be unfortunate. Or add in Ezetimibe. I’ll remove the statins first and check what my apoB is off them after those months. Maybe look into some supplement.

Improving LIPIDS takes time, trial-and-error, and a lot of testing!

1 Like
#2089

The difference between 55-59 could just be a statistical deviation. Honestly, that level is quite low. Mine is 102 so I would expect the statins to have a more noticeable effect.

When you’re already low, it’s hard to go lower.

5 Likes
#2090

Optimal levels are 30-40 that is what I am targeting. I wouldn’t mind if they were between 20-30 either.
Yes statins work well in hypercholestrolemia. I don’t have it right now. My genes tell me my apoB should be in 100th percentile, so maybe it is creeping up with chronological age…

As far as I know only PCSK9 inhibitors are used in trials to lower a low LDL to even lower levels?

#2091

Focused mainly on cholesterol, Dr. Brad weighs in.

1 Like
#2092

Are you doing weekly rapa dosing? When did you do the test apoB relative to the rapa dose?

I had apoB tested 7 days after a 7 mg dose (ie, just before I would normally take my weekly dose), and had a value of 59 mg/dl. About six weeks later, I tested only five days after dosing and it was a 75 mg/dl. I didn’t make an other changes to diet or supplements. It seems that there is significant variation over the course of a week, relative to when the rapa dose was taken.

I also saw a increase in Lp(a) with increasing time from the last dose. On day 5 it was about 170 nmol/L, and on day 7 it was 193 nmol/L.

It would be interesting to test both each day over the course of a week to get a curve of how lipids behave. Has anyone done this?

4 Likes
#2093

I don’t use rapa right now, and all of my measurements should’ve been far between any rapa doses.