#2767

I’ve literally just started today. 2.5mg eod. The dose response curve suggests most of the benefit comes from the 1st 1mg

I was aiming for 1mg ed but can only cut the pills in quarters…

“Rosuvastatin was associated with highly significant dose-dependent reductions in LDL cholesterol compared with placebo (p <0.001); decreases ranged from 34% (1 mg) to 65% (80 mg).”

3 Likes
#2768

I take 5mg rosuvastatin every other day and 5mg ezetimibe also every other day (alternating with rosuvastatin).

1 Like
#2769

I’m glad that’s working for you. Your ldl-c looks much happier at 95! :muscle:

I’m going to experiment with Rosuvastatin only at first and then look to add ezetimibe later next year.

1 Like
#2770

Important to note that in the ezetimibe/ALA paper, the dose of flax oil was only 2 grams. That’s not even half of a teaspoon. Would simply taking fatty acid supplement with a full meal containing more fat allow for greater micelle formation and full absorption of ALA? Also, the alleged mechanism is decreased micelle formation, but ezetimibe does not decrease absorption of fat-soluble vitamins, which it should if decreased micelles were a clinically relevant thing.

4 Likes
#2771

PRE-REGISTRATION

Heart disease
ApoB 74 mg/dl
CRP 0.4 mg/dl

Alzheimer’s
ApoA1 105 mg/dl

Liver
ALAT 0.75 μkat/L
ALP 1.8 μkat/L
ASAT 0.45 μkat/L

Muscle
CK 0.84 μkat/L

Using the based katal SI unit instead of the outdated international units.

Starting 5 mg rosuvastatin.

5 Likes
#2772

Lowering ApoB through diet alone.

2 Likes
#2773

Godspeed. Keep us posted.

1 Like
#2774

Good video, thanks. Fairly obvious to make these changes, he’s not really wiring up a nuclear reactor here. His Apo B started out at 160 so pretty easy to lower that.

Avoid carb, especially sucrose and flour. Eat less sat fat. That leaves protein and veg.

3 Likes
#2775

I have not been taking rapa since about 4 weeks ago, but took a dose this morning. In the last week or so I felt the worst I have felt perhaps in 20 years. Wondering if that was rapa withdrawal symptoms (since before I was using weekly but had sleep issues and decided to do monthly). Has any of you had similar problems (body aches, tired almost to the point of being lethargic, headache etc…) when stopped rapa? Btw, I’ve taken my dose 2 hours ago I feel about 70% better, few if any muscle pain, headaches gone, lower inflammation, and easier to walk and go about daily chores.
To be fair I’m not 100% my worsening feeling came from stopping RAPA, since in last two weeks I have added about 5-7 new substances that were mentioned on these boards(that I never did before).
Nevertheless i am pleasantly surprised to see RAPA have such an immediate good effect. Btw first time in about a year that I can easily say RAPA made a HUGE positive impact the way I feel. Perhaps earlier sessions I didn’t see much of difference because I was feeling relatively good anyway.
Forgot to add that about couple weeks ago I was infected with the 100 day cough bacteria and perhaps that was the cause of my feeling NOT good in last 10 days or so. In other words, it may not have anything to do with new substances I was taking and was mostly related to my infection. Damn wish it was much easier to find these things out LOL.

2 Likes
#2776

Be careful about taking Rapamycin when you have a bacterial infection. It could make it worse. You may want to wait until you recover first.

4 Likes
#2777

Great observation and that was first thing that came to mind but since I was really feeling my worst in a long long time I decided to risk it. So far after 3-4 hours taking RAPA dose I’m totally loving the results. It brought my old self back again, brisk on my feet, no aches, cleared head and even better mood(this one maybe because of the fact that all other negative symptoms disappeared thus makes sense to have better mood if your health improved drastically).

1 Like
#2778

IMO: The thing that is really at the base of lowering Apo-B isn’t diet. It’s losing weight and body fat along with some exercise.

Most people who have a BMI of 18-22 will have a lower Apo-B regardless of their diet, whether it is vegan, carnivore, or somewhere between.

"increasing BMI, also in a linear fashion (Table 3). Plasma apo B and apo A-I levels followed the same trend observed for LDL cholesterol and HDL cholesterol levels"

“Abundant evidence from epidemiological studies has shown that overweight status is positively related to a series of cardiovascular diseases like diabetes, hypertension, heart attacks and stroke”

Women:
“Complementing these findings, a meta-analysis of over 10 million participants has found that all-cause mortality is lowest in the normal BMI range (20–25)”

https://www.ahajournals.org/doi/full/10.1161/01.ATV.16.12.1509
https://www.sciencedirect.com/science/article/abs/pii/S0191886922004263#:~:text=In%20well-nourished%20populations%2C%20it,Lassek%20and%20Gaulin%2C%202018b).

2 Likes
#2779

Is this the David Feldman thing?

It will be a relief when this is all figured out and we can all be on the same page.

My current understanding is that the part of the LDL that matters is the sLDL. The small dense oxydized or glycated and impossible to recycle. The question is how to get rid of it. It looks like all the other LDL spends it’s time hauling around Triglycerides (which is good) and being part of the immune system (also good). So possibly we are getting closer to the truth.

I haven’t really got time to argue with anybody, just presenting this side for now.

1 Like
#2780

For those wanting to know / confirm the directions for apo A-I and HDL it’s:

“plasma HDL cholesterol levels significantly decreased (P <.0001) by increasing BMI, also in a linear fashion (Table 3)”

#2781

I am almost 66 years old… have LDL-C of 140 - 170 consistently. Considered high.

Have a Coronary Calcium Scan of zero.

In June 2024 will do another scan… and do the highest possible 3-D look. See if yes… my score is still zero. I eat a high satured fat (meat), eggs and whole milk diet… past 7 years.

Different phenotypes… different diets.

5 Likes
#2782

What is that @Agetron can you promise some more color?

1 Like
#2783

I will do a Cleerly Scan.

Link: Cleerly Versus Coronary Artery Calcium Score (CACS)

More detail and looks for soft plaque.

#2784

Got it, yeah that it what I would do too. AI powered also. Backed by top VCs like Founders Fund.

1 Like
#2785

I love it, but we probably don’t have the machine out here in the sticks. Also do you know what the cost is? Maybe my doc would order it, he’s worried about me.

1 Like
#2786

Hey Phred… I am just as isolated south of you in Kirksville, Missouri. Lol.

Working at a medical university… pretty sure I can find it in Missouri… might need to travel to Columbia, St. Louis or Kansas City. Or, when I am out of state in Phoenix, Arizona.

I would think you could locate a machine in Des Moines.

1 Like