#850

Hey Dee - Now on rapamycin/sirolimus 2 full years as of August 30th. My protocol first changed after 1.5 years of strictly 6mg once a week. Then starting the end of January of this year (2022) for 2 months I upped my dosage to 10 mg a week. Starting in late April I began experimenting with Grapefruit Juice (GFJ) with my dosage of 6mg to 8 mg to get a higher amount in my blood stream. Was at high as 57 ng/mL

For the last month I have been consistent with 6mg and GFJ and getting readings on 31 ng/mL. I have decided to stay the course (6mg and a cup of fresh GFJ) for 6 months plus - then I will do biological testing of Glycans and Methylation. Currently at 64.5 years these tests show me biological age at 37 in Glycans and 51 DNA Methylation. In 6 more months I want to see how much I moved forwardā€¦ or if I maintained or reversed some more years.

My life changed with more retained muscles and strength, collagen thickening, general euphoria, improved memory - definitely better, improved mouth gums, thickening skin, sex drive higher, a choking disorder went away (dysphagia), allergies vanished, improved blood flow, varicose vein reduction, visceral fat gone, arthritis gone tooā€¦ so yeah, feel all of the 14 year plus reversal in age that the tests tell me. Have no negative side effects except diarrhea at higher dosage - controllable at 31 ng/mL. I hope this helps. No intention of going off rapa.

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#851

I believe that Presidents get a CAC as part of their regular physical and yet Medicare doesnā€™t cover it.

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#852

Hi Agetron
Thank you for your results and protocol of Rapamycin, , you have done a great job for all us Rapam enthusiasts. I wish I could increase my dose but my glucose spikes, although Iā€™m finding the spike starts to diminish gradually over the 6 days prior to my next dose if 3 mg . I am sure I will never be able to increase the dose any higher but hopefully I will get some benefit eventually ( only taken it for 6 weeks so far) thank you again for the information
Dee

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#853

Hi again Agetron
Just one more question if you donā€™t mind, are you taking any other supplements , if so, what are you taking ?
Thank you
Dee

#854

There is evidence for pancreatic beta cell toxicity from rapamycin, most likely second to a reduction in beta cell mass. This is likely a mTOR 2 effect, but itā€™s not totally clear, and TOR 1 inhibition May be playing a role.

Since you seem to have some predisposition to glucose dysregulation, the wise course may be to continue with low dosing perhaps even at 10 day intervals .

This is more of a marathon than a sprint and weā€™re all different.

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#855

Hereā€™s a discussion of rapamycin and the pancreas

#856

Since your reference is from 2013 and 12 years later there is no alarm I think the risk factor is low.
A search of the last four years did not turn up any significant warnings as per panreatic beta cells.

#857

Actually all of this still isnā€™t clear, but it would seem that in those who are prone to be diabetic, ie. insulin resistant, mTOR May play an important role in maintaining glucose regulation. In that group in particular, I feel that itā€™s prudent to be careful with rapamycin dosing and intervals.

#858

Yes, Rivasp12, after reading the article, I will dose 3 mg every 10 days to be safe. Thanks for that

#859

This study shows that rapamycin reverses vascular dysfunction

https://onlinelibrary.wiley.com/doi/10.1111/acel.12524

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#860

Yeah, the absolute risk reduction on total mortality rates was 0.35% with statin use. A 10 minute walk a day beats that number without the side effects.

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#861

Wait, what?? What podcast? Iā€™ve listened to every single Peter Attia podcast on heart disease and all of them on rapamycin. He is absolutely, unabashedly pro-statin and prescribes them all the time for his patients.

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#862

Davin8r - Wait, what?? What podcast?

Link: 175 - The biology of aging, rapamycin, and other interventions that target the aging process - YouTube
Go to 1:01:15 Negative comments were made on statins by MK and PA and I may have also blended that with the more recent research and protocols on whether statins do more harmā€¦

Medical News Today Statins for cardiovascular health: Latest guidelines, evidence

  • Statin use would yield moderate benefit for those ages 40-75 with one or more factors that could increase the risk of cardiovascular disease, no history of cardiovascular disease, and an estimated 10-year cardiovascular event risk of 10% or greater.

  • Those of the same age with the same risk factors with a 10-year cardiovascular event risk factor of 7.5% to 10% will have a small net benefit from taking statins.

I hope this helps!

#863

To be fair, this wasnā€™r some kind of anti-statin rant.
They were comparing potential side effects of statins vs low dose/weekly rapamycin to emphasize the low toxicity of rapalogues. Sure, 1 in 20 or maybe 1 in 10 people donā€™t tolerate statins due to muscle aches/pains (Iā€™m one of them, in fact), but if you listen to Attiaā€™s other podcasts and read his emails on statins, heā€™s clearly a proponent and emphasizes the fact that benefits of keeping ApoB low (whether by statins or other means) continues to accrue over longer periods of time.

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#864

Exactly.
That podcast is now about 2 years oldā€¦ more recent research questions statinsā€¦ post positive trials are pharmaceutical based - of course - big money! More independent and recent information is questioning their value at all. And, if even LDL-C being higher is necessarily a problem.

Definitely not in my case for sure.

So yeahā€¦ thanks.

#865

Ok, good luck w/that.

#866

Peter Atilla just said that he has around 80% of his patients on statins either alone or in combination with another drug. I canā€™t remember if it was above age 40 or above age 50. I still am resisting taking them.

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#867

Well, there are plenty of ways to drop your ApoB without taking statins. Thatā€™s what the other 10-20% of Atillaā€™s patients are doing.

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#868

Zazim I am still am resisting taking them.

10 years ago my physician at that time wanted to put me on statins because of my higher LDL- C and I said I would change my diet. I never went back. It was easier to get a new physician. She thought she was giving good advice, but with a rating of zero on my Coronary Calcium Scan even pharmaceutical companies say donā€™t take a statin.

Think I dodged the bulletā€¦ my instincts were right. I am fine.

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To others do what you need to doā€¦ but maybe do a scan first!

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My LDL-C range 141 to 165ā€¦ high my whole life. Maybe 20 points higher since Rapamycin.

Check under the hood get a scanā€¦ and piece of mind.

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#869

By any chance did you do any lipid calculations to confirm your conclusion? Or do you discount due to the effect of high LDL-C?