#21

Bempedoic Acid and Ezetemibe from India (Brillo EZ) is the best solution to high lipids I have found in terms of effectiveness, price and ease of use.

I was sold on lipid lowering when I found out that when most people die of old age, it is usually a stroke or heart problem.

Also, mice and worms don’t have heart attacks, mice die of cancer so you won’t be able to see life extension for lipid treatments in mouse or worm trials.

The number one cause of death in humans is cardiovascular disease which usually strikes before 100 for those that will succumb. So analyzing centenarians for lipids is affected by survival bias.

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#22

I think the issue here is that everyone who reach this age range currently has spent 99.9% of their life under the “sick care” regime rather than any pro-active healthcare.
We are the ones being most proactive at healthcare that have the best chance of breaking the 122y.o. barrier.
(The greater your ratio of healthcare:sickcare the greater your chances of breaking that barrier).

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#23

Proper RYR includes a natural statin (Hydroxymethylglutaryl-CoA aka HMG-CoA reductase inhibitor) which is called Monacolin K aka Lovastatin.

However, RYR sold in the USA has the statin taken out normally, but I would check the RYR that you buy for this.

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#24

This is what dying of old age really means.

Natural causes,” on the other hand, typically means no obvious cause of death was identified for an elderly person’s death, even though it was likely caused by a common condition, such as a stroke, heart attack, or blood clot.

So, probably CVD does in those who die of natural causes. All the more reason to keep your lipids in check.

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#25

I’m just guessing, but in a lot of cases CVD will turn your life into sickcare - stroke, heart attack, you can’t walk, talk, or think properly, so that is making it very important even if it didn’t affect total mortality that much (in the case someone had the potential to live to 100 or whatever, then it would as not only would it affect QoL but also bottleneck longevity).

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#26

What is GG? (Can’t find it in thread)

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#27

I have excellent results on rosuvastatin 5 mg, ezetimibe 5 mg, and a-cyclodextrin once a day with morning smoothie. Just for only 1 month, my total cholesterol dropped from 208 to 184, and my LDL from 98 to 76. Triglycerides remain the same at 49.

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#28

@LaraPo

Here’s the original thread on gg

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#29

I am surprised to hear Dr Green is more concerned about the effect of statins on insulin resistance vs the potential downside of dyslipidemia from Rapa. My personal experience is that Rapa has significantly increased my LDL. He must have seen that in a subset of his patients and so I wonder how he’s treating that? I’ve had to cut back my use of Rapa (currently trying 4mg every two weeks, down from 6mg weekly) while simultaneously adding ezetimibe to my current statin therapy.

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#30

I had the same thing happen with me, I have developed extreme pain around my elbows after a month on 5 mg of rosuvastatin.

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