#1

I just started taking rapamycin ( starting low dose and titrate up to 6mg ) but I see some protocols suggest 8 weeks on and 5 weeks off.
After a 5 week break should I restart at a low dose or go straight away to 6mg?

any thoughts?

Im also on a low dose of tesosterone injection every 2 weeks as well as metformin.

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Optimizing the Dosing Schedule of Rapamycin / Everolimus to Minimize Side Effect Risks - New Spreadsheet
#2

I’d say go for the full dose even if you do time off after you have reached the desired dose from the start. I do take a rest sometimes, but not on a regular schedule, i.e. 4-5 weeks on and then couple weeks of. (just like to give my body a break and see what happens). however, I know there is actually people who do it on a regular schedule i.e. 8 weeks on, 4 weeks as an example. From I’ve seen so far there is no agreed way of doing it, regarding the dose nor the intervals. Still a fluid self-experiment for everyone. Try to take notes how you feel and experiment with dose and interval and perhaps find what works best for you.
In my case I tried all different doses from 1MG to 12 MG with EVO a GFJ and now I’ve settled at 2 with GFJ (just seems to be the right dose for me where i get no side effect and seem to feel same way/benefits as with higher doses). The thing though is any positive effect I tend to get is only one day (most) and second day (a little) after I take my dose. then I drift to same self after day two.

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#3

Welcome to this great resource. As you noted there are no fixed protocols for dosing or washouts. In addition to “how you feel,” I’d recommend blood tests after a month to see if there are side effects such as high lipids or blood glucose or low white blood cells, which cann all be affected by rapamycin. i also do a month’s washout after six months on.

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