#206

I’m very happy to hear your great news!

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#207

Glad to hear, unfortunately for me my cat doesn’t seems responsive to rapamycin. What dosage do you use do you use enteric coated capsules ?
I’m giving my cat with hcm some glynac in addition now

#208

I’m using the 0.3 mg/kg used in the cat-HCM study that showed slight improvement so for my cat about 2mg. And because I get the rapamycin through Dr. Kevin Toman who is a veterinarian, he sells an oil-based solution rapamycin which I give to my cat with a liquid syringe rather than a pill.

I will admit that my cat’s heart arrhythmia sounded like it was worsening shortly after diagnosis last year, even with the weekly oil-based dosage, so I decided to increase his dosage to 3 times a week. Because the oil-based solution is pricier than pill form, I wasn’t able to afford 3x a week of the oil so I used 2mg of Rapacan for the other two days. I did this for 5-6 months and then when back to just once weekly until I got results.

With these results I will most likely do another short-term 3x a week dosage for a few months as I found no negative side effects at that dosage even with my cat taking 3 other medications (pimobendan, sotalol, and clopidogrel).

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#209

Thanks for sharing, did you discuss with a doctor about the 3x dosage ? I’m wondering if I should try to do something similar for a few month since it evolved badly for mine despite using 1/week rapamycin at 0.3mg/kg

#210

Unfortunately I did the 3x a week dosage on my own after extensive research. And just beware, most vets will not want to experiment outside of what dosages are being studied because they don’t want to take a risk on what they don’t know.

My reasoning for why I chose the 3x a week is because Dr. Matt Kaeberlein did a study on dogs using rapamycin 3x a week at 0.15mg/kg and saw little to no effect, good or bad. So I knew low dose 3x a week is likely safe. Then from the cat/HCM study, I know that 0.3mg/kg was safe and obviously I was already using that dose. So I just kind of combined those methods.

Just a tip if you do decide to try 3x a week is to go from 1x a week to 2x week and then wait a week or two to make sure that increasing to 2x a week isn’t causing any side effects in your cat. Every cat is different so just ease into it and if everything seems great after a couple weeks on 2x a week, then try 3x a week.

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#211

Thanks for replying, how old is your cat, what race and is it obese or just muscular (because of the weight, it’s the same as my maine coon who is really strong but not fat)

#212

This is OT as it pertains to bexagliflozin which is an SGLT2i, but it was mentioned in the other thread. Meanwhile there are many cats that are diabetic, so I thought this might be of interest:

Safety and effectiveness of the sodium-glucose cotransporter inhibitor bexagliflozin in cats newly diagnosed with diabetes mellitus

“Bexagliflozin decreased hyperglycemia and observed clinical signs in cats newly diagnosed with DM. As a once‐daily PO medication, bexagliflozin may simplify management of DM in cats.”

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