#226

Hi Tina I’m also from Australia - can I find out who is your vet cardiologist?

#227

Here is a cat study rather than a dog study: “Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy.”

The dosage used was: “intermittent low dose (0.15 mg/kg) and high dose
(0.30 mg/kg) of DR oral rapamycin once weekly. Rapamycin remained safe and well tolerated in cats receiving both doses for eight weeks.”

I am currently dosing my two cats, weighing approximately 4 kg each, with 1mg of rapamycin/week. This is approximately 80% of their high dose of 0.30 mg/kg.

I recently found a Pill Pocket flavor that my cats will eat, so that is how I feed my cats the rapamycin pill.

This dose is mainly one of convenience, as they have no known problems and are relatively young, at 3+ years old.

It’s possible that someone has posted this before, but not recently.

https://www.mdpi.com/2076-2615/13/20/3184

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#228

Correct. Sorry I haven’t logged in for a while. Yes he swallows them whole and I get a 1mg and a .5 mg as he weighs 5.5 kg. So I needed one half tablet however now managed to find the right doses and intact are enteric. I had his first scan which was a year after and the heart condition hasn’t progressed. The cardiologist was pleasantly surprised although this was his suggestion. He isn’t on any beta blockers as when he started on this his bloods were off slightly from surgery. So I ll do bloods and check but so far no more occuramces of heart failure since starting rapa

#229

Hi Cindy
Richard Whoolley is the person to see and get a script if in Aus. My cat has been ok since starting this and he is on frusamide and blood thinner. He isn’t on any beta blockers but I am doing a blood test and we will review. So far his heart failure hasn’t progressed and would say due to rapa.

#230

Hi yes correct either emergency vet clinic should be able to do that or Richard Woolley

Www.cprvictoria.com.au
If in Australia.

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#231

Hello everyone, our Sphynx (Vlad, 3.5 years) is stage B1/B2 but been stable for almost 2 years now, screenings every 6 months, no significant progression. Great, but also makes me anxious to start rapamycin asap. Our cardiologist said better wait for the FDA-approved Felycin and not venture with the custom-made pills/liquid.

Been hysterically waiting for Felycin, but we live in Europe (Greece). Any tips on how to secure it as soon as it is released in the US?

Thank you

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#232

Felycin is being developed/marketed by an Irish company. I would imagine that they would know how to obtain it ASAP in Europe. It is in their commercial interest to market it as widely as possible. Perhaps you could contact them and ask about availability timeframes for Europe/Greece.

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#233

Thanks! Since the company was acquired by PBI-Gordon (US) and the HALT study is in the US, I thought the whole product was still very US-focused. But I will contact Triumvet again, I’m just expecting a generic response… Thank you anyway

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#234

I’m not caught up so sorry if this is not applicable to you, but you don’t need custom pills etc…

My cats, and many pets, are getting one of my rapa pills each week. Costs less than $1 per week.

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#235

I contacted them too and got a generic response. What I do for my cat but I don’t know if that’s similar to triumvet is coat the rapamycin pills myself. I split them in half, put them in a capsule and use a special enteric coat on it, I add a bit of filler inside like vitamin powder to prevent as much air as possible in it

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#236

Thank you both. I alternate between prudently waiting for Felycin and just taking the matter in my own hands like many of you brave people on here. I know in the end it’s one active ingredient and a vessel resistant to stomach acidity, but I still don’t feel confident enough to DIY it. If by August Felycin is not released and available, I might change my mind.

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#237

Thank you for posting this. Great to hear your fur baby is improving. I’ll be using Dr Kevin as there are so many +ve stories :wink:

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#238

I am also waiting for Felycin, this is the company who manufacture it ;

I messaged them 20/6/25 and had no response yet but plan to make a call to them very soon.
Have you any updates ??

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#239

Great news everyone - Triumvet is finally taking pre-orders for deliveries end of July !!! I am copying the email I received so that everyone can see. Hopefully the link works too, but let me know otherwise and I can post it separately.

Blockquote

It’s finally happened! Felycin®-CA1 is officially launched!

Last week at the American College of Veterinary Internal Medicine (ACVIM) conference PRN Pharmacal and TriviumVet welcomed over 70 esteemed members of the veterinary cardiology and research communities to the Felycin®-CA1 launch event.

Felycin-CA1 is the first and only FDA conditionally approved once-weekly drug for the management of ventricular hypertrophy in cats with subclinical HCM.

Pre-order NOW

Veterinarians can now register to become first prescribers ahead of the U.S. launch in late July/early August.

Blockquote

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#240

Great news, however I called the company in Waterford , ROI . The kind lady told me the medication isnt available in Europe yet & will be only sold in USA . They are going through the approval process for Europe sales but that takes time. If anyone knows how to import to Europe from USA please share

Thank You Folks

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#241

Correct @John_G. Sorry if my message was misleading, it is only US for now.

But I would suggest you establish a link with a US cardiologist who is willing to prescribe it (either directly to you or through your local vet). Use your personal connections, vets of friends, etc.

I did not want to wait more for the European release and am doing everything I can to procure it from a US vet. I am in contact with 2 vets, and they typically ask for your cat’s profile info and liver test results, and any previous echographies, x rays, etc.

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#242

Thank you for replying . Like you I don’t want to wait either .

Please can you share the vets details as I would like to try and use them also. If yes you can private message me the details . I would really appreciate your help

Thanks John

#243

I just asked my IM vet, who does telemedicine, if she can rx out of state, I’ll post here if that is allowed. I can’t imagine that she could do this out of the country though.

Personally, I have not heard why this is better, so until I hear a reason, I’ll continue to give my own cats my pills that are less than $1 per week.

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#244

Hi Beth many thanks. How long have you been using the pills for HCM and are they effective ? My Ragdoll has just been diagnosed with HCM no outward or physcial signs , it was picked up by a heart murmur concern

Thanks John

#245

A ragdoll is my dream cat!!!

I don’t have a helpful answer for you, but I’ll just share my personal experience.

I had two cats we lost to heart (one with CKD) issues over the last two years. And two of my three cats also have murmurs.

The cardiologist was involved with the prior two cats who were on medications, and he saw the two current ones last year. The current cats don’t have anything bad enough to medicate. His only general advice is, for CKD, don’t give old cats with stiff hearts more than 50ml of fluids per day (I have to do that for 2 cats…kill me)

My cats are 16, 17, and 18, and the two older ones have comorbities, so I’m making a quality of life choice and just treating them with rapa and they are not going back for follow-ups to the cardiologist. They will not leave the house short of an emergency and I have vets do house calls for labs. I share this because my answer is I have no way of knowing if this is working and I imagine I never will.

Knowing I won’t take them to the cardiologist short of an obvious reason to do so, last month a vet recommended we do a probnp test to show if their hearts were under any stress. It was the first time anyone had mentioned that test to me. Both their tests came back looking good.

Their cardiologist has incredible respect for their IM vet, so he has told me he feels she can manage their care every bit as well as he can. I mention this because I’m not sure I’d make the same decisions if I had an average vet.

It was in aprox Jan that I asked her about giving them rapa and she was on board and told me how to dose them. She has other patient dogs getting rapa. I haven’t given it to them every week, but many weeks.

The 16 year old has never shown signs of aging, but the older two have perked up quite a bit since starting rapa. The one started a different immunotherapy at the same time, so of course it could be from that, no way to know.

The one on the new immunotherapy started exploring and being curious again, vs just hanging out in a small part of the house. At the end of last year she lost almost all of her hearing (to the point of shouting behind her and she had no idea), but now a lot of her hearing has come back… again, no idea if it’s the rapa. She is acting younger than she had in many years. (Still old with ckd, occassional seizures, and mast cell tumor, but still seems happy with tons of quality of life)

So, all this is to say that I have a beyond brilliant IM vet and if she says to give my cats rapa, I see zero reason for you to wait for a cat specific drug (that will probably cost more than the $2.50 per month per cat I’m paying now). I would pay what I need to pay the second I hear there is a reason to, but she has not told me I should change anything and I haven’t heard anything here either.

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