Rapamycin increases Alzheimer’s-associated plaques in mice, study finds - thoughts

[Agetron]

Hey All : I had not seen this information in the news feed or in comments on forum. Rapamycin users thoughts on this information? I know my memory is stronger since being on Rapmycin the past 2 years. Of interest, but I am not really concerned.

Rapamycin increases Alzheimer’s-associated plaques in mice, study finds - UT Health San Antonio.

[Arhu]

there is a big topic already

Rapamycin increases Alzheimer's-associated plaques in mice, study finds

Well this made my day…cognitive is my #1 focus. Thankfully (hopefully) it dosen’t translate well to humans, given the failure of this mouse model in AD translation. “The experiments were conducted in a specific mouse strain called the 5XFAD, which is used as a model for human Alzheimer’s disease” This is the problem with ITP…mice don’t get cognitive dysfunction in old age like humans. There is plenty of literature in support of Rapamycin. “Our data suggest that inhibition of mTOR by rapamycin, an intervention that extends lifespan in mice, can slow or block AD progression in a transgenic mouse model of the disease. Rapamycin, already used in clinical settings, may be a potentially effective therapeutic agent for the treatment of AD.” Phase 2 clinical trial with…

[Agetron]

Ahhh… MAC already posted. I put this out there as the “collective - we” on this site want to see everything - unflitered to make our best guess on choices.

But definitely, l will continue to follow the research on this area.