Are any of you on a regimen of Rapa and Metformin? If so what is the regimen you following, i.e. dosage and frequency?
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Hi, welcome to the site! I was on both rapamycin (6mg/week) and metformin (1500mg Slow Release 1 X per day) - but this was about two years ago.
The dosing of rapamycin was in the typical dose range that many people use in anti-aging applications - you can see this post on rapamycin dosing for more information.
I took 1500mg of metformin per day because that was what the TAME (trial of metformin in Aging) trial is planning to use (see this presentation on the TAME Trial).
But⊠after I saw the news on metformin with regard to impact on muscle recovery after exercise (I exercise a lot - most days of the week), I decided to skip the metformin and now Iâm just on Rapamycin.
If you exercise less frequently, metformin may be a good fit for you - I donât know.
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Thank you Rap!! Very helpful.
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I love to use my own experience whenever possible. I did 3 bouts of metformin and each time my exercise capacity diminished significantly. Thereâs no doubt about it and Iâll never try it again.
I agree with Brad that non diabetics shouldnât take it.
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MAC
#7
The literature, in those pesky mice, is just short of amazing results re Berberine. But generally dysfunctional animal models. Thereâs that translation thing againâŠ
I tried berberine. Less of an exercise impact compared with metformin but I still dumped it.
I like things that enhance my exercise capacity, not diminish it.
Rapamycin worked and so does pine bark.
The pde5 inhibitors work pretty well also but the nasal congestion is bothersome. I can negate it with dragons blood .
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KarlT
#9
The current medical literature does not support Metformin use in non diabetics.
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HmmmâŠ
Might need to take a 6-month break on Metformin and see.
Certainly canât afford to lose any muscle mass that I work so hard to get⊠lol.
Meh. I have been taking low-dose metformin for so long that I canât remember when I started.
Maybe it retards training a little bit. I didnât notice. So, more muscle or longer life?
I recently added Jardiance ( empagliflozin), so now I take metformin, 500 mg, in the evening and 20 mg of empagliflozin in the morning. This may not be optimal, but it has certainly lowered my fasting glucose measurement. Maybe I should split the doses and take them together. i.e. 250 mg, metformin with 10 mg empagliflozin? Does anyone here take both?
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Both⊠I want strength and years⊠hahaha.
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DrT
#14
I canât speak for anyone else but Iâve been taking 500 mg slow-release metformin for about 12 years now and 2mg/week Sirolimus but only for a couple of months.
Iâve always been a gym-junkie and havenât noticed any effect on strength, except an increase since Sirolimus. Iâve never been much of a runner but still run about 6km twice a week but only in fine weather (LOL).
I have very low insulin level (2 IU/L) and fasting glucose is usually 4.3-4.5, so happy with that at age 65.
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Dr Green (the Philly area MD who takes/prescribes Rapa, etc) had posted his personal labs and last I saw (few years back) , his fasting blood sugar was slowly creeping up over the years taking rapa + metforminâmight have been worse without the metformin.
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José
#16
???
Dr. Alan Green is in Little Neck, New York
Correct, my bad but that is the person I was talking about and his posted labs.
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I take 500mg of metformin and do power yoga 3x/week. I skip metformin 12 hrs prior to my workout. Iâm 52, 12% body fat, 6â2â 165lbs (my high school weight). I was stuck at 185 before starting metformin. Iâm sexy AF according to my wife Lol. I just started rapamycin 1mg/week and will up it weekly until I hit 5mg then get new blood work.
As far as other things I take, I follow David Sinclairs routine almost to a T.
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Another geroscience scientist take on metformin.
