Um novo estudo descobriu que a autofagia desempenha um papel importante na ativação das células-tronco do folículo capilar e na manutenção do ciclo de crescimento do cabelo. Ao aumentar a autofagia, a rapamicina melhorou o crescimento do cabelo em ratos e numa cultura de órgãos capilares humanos.
História completa:
Artigo Fonte:
Resultados: A autofagia em células-tronco do folículo capilar (HFSC) foi maior durante a transição do telógeno para o anágeno. A inibição da autofagia com 3-MA levou à entrada precoce em catágeno e telógeno prolongado, enquanto Rapa promoveu autofagia e crescimento capilar. A autofagia ativou o HFSC aumentando a expressão e atividade da lactato desidrogenase (Ldha) do HFSC, transformando assim o metabolismo do HFSC em glicólise. A inibição da expressão de Ldha neutralizou os efeitos da autofagia.
Conclusões: A autofagia ativou o HFSC, promovendo a transição do metabolismo do HFSC para a glicólise, iniciando finalmente o ciclo do folículo capilar e promovendo o crescimento capilar.
Artigo Completo (Acesso Aberto)
Outros artigos sobre crescimento capilar e rapamicina:
Aqui: a atividade do mTORC1 regula negativamente o crescimento e a pigmentação do folículo capilar humano
e:
Estimulação do crescimento capilar por pequenas moléculas que ativam a autofagia
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30699-0
'A rapamicina (1.6 mM) induz a regeneração capilar. Camundongos machos foram barbeados no 43º dia pós-natal e tratados topicamente em dias alternados. As fotografias foram tiradas no dia 37 pós-tratamento.
Tópicos de discussão relacionados:
Aqui: Rapamicina para crescimento e pigmentação capilar (inclui instruções do soro capilar DIY Rapamicina)
Aqui: Regime tópico de crescimento capilar com rapamicina
11 Likes
murraci
#2
I’ve probably seen around 100 papers on rapamycin now. I’d say 95 of those resulted in positive results for whatever they were testing. You could throw darts at a dartboard to test any metric of human healthspan and almost certain to find rapamycin improves it.
5 Likes
The sad thing is that negative results are less likely to be published for anything. However, more efficient mitochondria are likely to make any issue better.
3 Likes
murraci
#4
In many cases yes but I don’t think in the case of rapamycin because nobody has a patent on it. The people doing the studies have no dog in any hunt.
6 Likes
I do wonder whether high doses of oral rapamycin can accumulate in the hair follicle aswell.
I think it is a general problem with research. In a sense there is an inherent systemic pressure for positive results. When it comes to rapamycin and hair i think rapamycin helps.
1 Like
José
#7
FWIW
Dissolve rapamycin in DMSO, then make a solution and rub into the scalp.
You will deliver rapamycin into the hair follicle/hair stem cells (HFSCs)
1 Like
This is strictly anecdotal, but my cat was shaved almost to the skin for his ultrasound. The hair started growing back, but slowly. After he had been on Rapa for a couple of weeks, his fur suddenly started growing back very quickly, and is now very thick. This could just be his winter coat coming in, or maybe I’m seeing what I want to see, but the results seem to confirm the mouse study
4 Likes
DrT
#9
Hmmm. This suggests an experiment. First, you need a sufficient number of cats. Let’s say 20 controls and 20 to receive the rapamycin. They should be shorthair cats…easier to shave.
Second; begin by herding each group of cats toward the lab….oh, never mind!!
7 Likes
DrT
#10
So it seems that topical rapamycin, metformin and alpha-KG are all fairly effective on the mice and also have some effect on human follicles.
I’m tempted to try all 3 concurrently but then, if it helps, I won’t know what is best. Has anyone tried any of these yet?
1 Like
Arhu
#11
With topical applications you can do left/right side comparisons
2 Likes
DrT
#12
True. I used to do that several years ago. Treatment on left side. Right side was control.
1 Like
You forgot the sedative (for you, not the cats) and the chain mail gauntlets
6 Likes
Was the difference very significant?
Possibly a daft question here, the study shows results in 11 days. Assuming this was also effective in human HFSCs would we be looking at 11 days, longer or shorter?
1 Like
Melih
#17
Mice hair growth cycle is like ~28 days total from the telegon to the anagen phase.
Whereas a human hair growth cycle can go anywhere from a couple months to a couple years.
The healthier the hair the longer the hair cycle is in the anagen phase.
3 Likes
DrT
#18
It’s so long ago I even forget what I was trying. And no; no significant difference anyway. 
1 Like
DrT
#19
