I was using it for months. My cholesterol went up. I had less energy. I had mild canker sores pop up in my mouth. My glucose level increased. I think this is actually mildly poisonous. The old studies were bullshit. I’d advise you guys to stop taking it. Most guys on here aren’t serious biohackers anyway, but please do not risk your health with dubious studies from lazy “scientists” who face no consequences for incompetent/fabricated work.
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AnUser
#2
These side effects are rare according to the Mannick trial (unless everolimus has fewer side effects or is some other way flawed with regards to this), the BJ video discussion starts here: Bryan Johnson, Is he the New Poster Child for Rapamycin Use? - #621 by nikari, and there’s multiple threads on these types of side effects, see e.g:
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Hahaha… thank you Bryan Johnson – wanna be!
My N=1 from biological tests and blood panels over the past 5 years beg to differ with you!
Time to move on buttercup!
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LaraPo
#4
@Chu_Kim Are you sure your dose was right? I mean you can poison yourself with any medication (or even water).
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Bud you joined January 12th and have read 1 hour. Hardly a deep dive. And yes you are fairly young too…soooo, maybe your dose was too high. 1 or 2 mg might be plenty for one who is your age.
And… perhaps you are some of the group based on genetics and phenotype that it just doesn’t work for. Sucks.
For me, it is Metformin that is a gut punch… I just can’t make it work for me. Tried and tried. Good luck living forever.
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LaraPo
#6
You list “occasional strange sensation” in the back of your neck which most feels like muscle tiredness as a Rapamycin side effect. What if it’s just your pillow or bad posture or muscle ache after exercising or… could be 100 other reasons.
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LaraPo
#7
Metformin doesn’t work well for me either. I also tried and tried. My doc just discontinued it for me. I don’t have diabetes, may be it’s the reason it doesn’t do any good for me.
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Yep… however, acarbose is easy… and does good in combo with rapamycin according to researchers.
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Acarbose seems to have a very simple mechanism of action. Less rapid glucose elevations, and flattening the curve after a meal. Metformin seems to do a whole smorgasbord of things inside cells of different organs and I personally wouldn’t use it unless I was diabetic.
As opposed to the authors of that pre-print:
R.Sehgal and A.H.C. are named as co-inventors of Systems Age which has been patented and licensed to TruDiagnostic. A.H.C. has received consulting fees from TruDiagnostic and FOXO Biosciences. R.Sehgal has received consulting fees from TruDiagnostic, LongevityTech.fund and Cambrian BioPharma. V.D., R.Smith and N.C are employees of TruDiagnostic Inc and developed OMICmAge. The other authors do not declare any conflicts of interest.
Of course, they can have COIs and simultaneously do real science, but let’s not pretend they performed and are publishing this study out of pure charity. They have their own motivations too.
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Me three. I get exhaustion early in the morning when taking metformin, even on a small dose. Fine with acarbose and SGLT2i’s thought (I did have to start on a half dose of SGLT2i).
Ouch, lol
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I think it’s lazy to quickly jump on a drug based on some good or bad publicity. Extensive reading about rapamycin - which requires one not to be lazy, at a minimum - should have alerted you to these well known side effects of rapamycin. Experiencing those side effects should not have come as a surprise, and you should have not needed that paper to be fully informed of its unremarkable findings.
You should have been aware of all this before you took rapamycin. And having read about these side effects, you should not have been lazy, and have explored what that means for your possible taking, or not, of rapamycin. Can those side effects be ameliorated or abolished, leaving only the possible beneficial effects? What strategies are available to you should you experience negative effects. How are you going to objectively track the effects of rapamycin with tests before taking it, and after taking it. What are the criteria for you definitely stopping rapamycin, as it’s a net negative in your case.
All this requires extensive research before hopping on rapamycin or any other drug or drug combination. One shouldn’t be lazy when it comes to one’s health and choices of whether you take any drug or not.
Not making all those preparations SUCKS, because it dooms you to forever jumping on or off drugs and supplements with every random article, yt video, study and rumor. The resources are out there, including on this site. But that requires one not to be lazy and do the research.
Rapamycin is a serious drug. Only seriously dedicated and careful people should be taking it. Clearly it is not a drug you should be taking, and it is good you have decided to abandon it. A super fast racing car should not be driven by someone who doesn’t take the time to learn to drive even a street car.
Best of luck!
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Dude does a twitch style post worthy of a 14 year old and then accuses these forum members of not being serious 
I propose we close this clusterF thread before it hits the fan.
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