Rapamycin inhibits the creation of WBCs. Hence your body’s ability to fight infection is reduced and if you have an infection taking rapamycin is probably not a good idea. Rapamycin may result in a stronger immune system once it has faded away and just leaves better mitochondria, but it strikes me you should make sure this clears first.
Sucking some melatonin so that it gets into your gums might help, but it might not.
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I finished the antibiotics a couple of weeks ago. I’ve probably not taken rapamycin for 3 weeks now.
My dentist also gave me a special syringe that allows me to shoot warm salt water under the gum to prevent food being stuck there. I think that would allow me to avoid this flare up. I had this flare up a couple of times while using rapamycin before, and I had also had this happen numerous times in my life. It happened quite a lot when I was a eating a vegan diet many, many years ago.
I’m going to get the tooth removed at some point I’ve decided, unless the nerve in my jaw makes it too risky.
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Jonas
#48
New Rapamycin Heart Function Study: UofT by Dean L. Kellogg, Jr., MD, PhD (recruiting)
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Great chart of average life span; average life span with medical intervention, and average life span using rapamycin and medical intervention.
You can see where rapamycin gives 15 extra years of health span. Excellent.
Based on my 5 years use of rapamycin and looking at my inflammation and DNA methylation tests… I am there. 12 to 21 years benefit. I am confident that these results would not be possible without rapamycin.
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Jonas
#51
Could you update us with your current regimen?
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Currently I am doing the following prescriptions
Physician supervision.
Weekly:
Rapamycin - Zydus 6 mg straight. No GFJ.
TRT - Cypionate 200 mg 1 ml, thigh injection
Doxycycline 200 mg
Every day medications:
HGH - meditrope blacktops 3.3 iu butt injection
Proscar - finasteride 5 mg
Cialis - tadalafil 5 mg
Minoxidil 5 mg
‐—‐‐-------------------------------------------------------------
Every day over the counter supplements:
Taurine BulkSupplements 1 teaspoon in coffee
Creatine Monohydrate 1 teaspoon in coffee
Lecithin Sunflower Carlyle 2400 mg (healthy sperm loads seriously) 2 capsules
DHEA Wal-Mart 100 mg
Vitamin D3 Spring Valley 4,000 iu
Zinc 22 mg
Lithium Orotate Horbaach 130 mg =5 mg Lithium
Melatonin 30 mg
Magnesium Nature made 200 mg
Boron Horbaach 6 mg
Quercetin bromelain Luma 500 mg
Omega 3 Carlsons 1,600 mg
Astaxanthin Naturebell 24 mg
B12 Spring Valley 5,000 mcg
Vitamin C 1000 mg
K2 Spring Valley 200 mcg
Vitamin E Nature made 500 mg
NAC 600 mg
Any questions?
Muscle resistance on machines 1 hour 15 minutes every other day 
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Whoa. You’re taking 50mg boron every day? I take 6mg, and I thought that was a medium dose.
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Whoops you’re right just 2 pills = 6mg. I have corrected.
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Why no SGLT2-i? Just curious because you seem pretty aggressive with your medications/supplements but you’re omitting what might be the most promising one out there
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Thanks for the heads up, and actually am seeing my physician next week. Did a full blood panel last Friday to see the effects of HGH on IGF-1 and see where I am at overall.
A discussion of SGLT2-i as a prescription will be brought up since I can"t do metformin (body hates it).
Will also be checking on rilmenidine for hypertension. My B/P has always run higher (family trait) 125/80 - TRT doesn’t help that - get high bumps at dosing.
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I wouldn’t get hung up on rilmenidine, you’re not a worm. Based on clinical evidence, I’d look at telmisartan to start off.
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Hahaha… thanks.
I am looking for a mild approach as my B/P is normal for my family.
Rilmenidine is an antihypertensive medication primarily used to treat mild to moderate essential hypertension (high blood pressure).
And maybe - rilmenidine, like finasteride - might be more beneficial in the long run than one might think.
Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging.
Aaron Havas, Adarsh Rajesh, Xue Lei, Jessica Proulx, Karl Nathan Miller, Adam Field, Andrew Davis, Marcos Garcia Teneche, Armin Aabish Gandhi and Peter D. Adams
bioRxiv. posted 28 July 2025, 10.1101/2025.07.25.666837
http://biorxiv.org/content/early/2025/07/28/2025.07.25.666837
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I had a similar situation with an implant. Found that brushing with food grade tea tree oil reduced the inflammation / ended the infection.
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Now you can take rapamycin without problem?
I’m about to start rapamycin again tomorrow. I will get some tea tree oil.
Do you use the tea tree oil daily or only when inflammation/infection happens?
In mice. On a high fat diet. What would be interesting is whether rapamycin affects human liver health when the liver is stressed not by high fat diet, but by a high intake of supplements and medications 
.
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Hi, I thought you had GlyNac in your regim? If you did, I wounder why you dropped it?
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Jonas
#64
Rapamycin paper from China on Precision Medicine Application by Dr H Zhang 2023 (highly regarded rapamycin research in China)
His other papers are:
Summary:
Core Focus: Overcoming rapamycin resistance (DEPTOR, MEK, autophagy).
Strategy: Rational drug combos (e.g., + ER stress/MEK/autophagy inhibitors).
Impact: Biomarkers (DEPTOR) guide therapy; repurposing for side-effect protection
And there is youtube video but it’s in Chinese (can some get English transcript from this)
Jonas
#65
On a related note, the new mechanism of Metformin has been discovered in the brain. I am currently still on a weekly rapamycin + metformin x 5 per week regimen.
https://www.science.org/doi/10.1126/sciadv.adu3700
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