I hope you will have the opportunity to enjoy Sweden once more in the not-so-distant future. Yesterday I came back from four days in Prague—my first time there. A wonderful trip. I think I remember that you have ancestry in Czechia? I’m not a carnivore, nor a vegetarian either, but in Prague I indulged in a superb pork knuckle, and some other food that might not be superb for longevity.
That said, here comes my rapamycin update for the first part of 2025.
Rationale for Restarting My Longevity Regimen
After observing mildly elevated fasting glucose levels, I chose to temporarily discontinue my previous longevity regimen in its entirety. The goal was to reduce the number of variables and establish a controlled baseline to better evaluate the metabolic effects of individual supplements.
Before restarting, I continued my corrrection of documented low levels of key micronutrients—specifically magnesium and vitamin D—which are essential for glucose regulation, mitochondrial function, and immune homeostasis. These supplements were maintained throughout, as they address clinically relevant needs rather than experimental optimization.
I have since initiated a sequential, stepwise reintroduction of supplements with low interaction risk, particularly avoiding those metabolized via the CYP3A4 pathway. The order of reintroduction is as follows:
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Taurine – supports osmoregulation, mitochondrial protection, and may improve glucose stability.
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GlyNAC (glycine + N-acetylcysteine) – enhances glutathione production, reduces oxidative stress, and may improve insulin sensitivity.
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Creatine – supports cellular energy metabolism, cognition, and muscle function, with no known CYP-related interactions.
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Inulin – a prebiotic fiber that promotes gut microbiota health and short-chain fatty acid production, with beneficial effects on glucose regulation.
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Apple cider vinegar – may reduce postprandial glucose spikes and improve insulin sensitivity via delayed gastric emptying.
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Lithium (low-dose) – offers neuroprotective and mood-stabilizing effects, potentially beneficial for longevity via GSK3β inhibition.
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Rapamycin (low-dose, intermittent use) – an mTOR inhibitor with potential longevity-enhancing effects through modulation of aging, metabolism, and mitochondrial function.
Supplements such as polyphenols and berberine, which influence CYP3A4, will be introduced at a later stage—once a stable baseline has been re-established and the individual effects of the earlier interventions can be clearly observed.
Biomarker Monitoring:
The primary marker being monitored continuously is fasting blood glucose (daily).
Other biomarkers will be evaluated in about a month, once a more stable intervention phase is underway.
Lifestyle:
Diet and physical activity remain constant throughout the entire protocol to minimize external variability that could affect the interpretation of results.
