Aging is associated with a global decline in stem cell function. To date, several strategies have been proposed to rejuvenate aged stem cells: most of these result in functional improvement of the tissue where the stem cells reside, but the impact on the lifespan of the whole organism has been less clearly established. Here, we review some of the most recent work dealing with interventions that improve the regenerative capacity of aged somatic stem cells in mammals and that might have important translational possibilities. Overall, we underscore that somatic stem cell rejuvenation represents a strategy to improve tissue homeostasis upon aging and present some recent approaches with the potential to affect health span and lifespan of the whole organism.
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14865
7 Likes
Very interesting.
“ In the skeletal muscle, MuSCs (muscle stem cells) seem to enter a deep quiescent state after fasting, which is not recovered by re-feeding. This slows muscle regeneration but improves the survival of these stem cells, effects which are also observed using CR. FMD followed by re-feeding showed an increase in MuSC number to more youthful levels, with an improvement in the locomotor abilities of the aged mice”.
Go FMD!
2 Likes
