I doubt it will stop working with regard to glucose control when used as prescribed.
It may stop working for weight loss, some have experienced that but so far it is enabling solid weight maintenance for the folks I know.
The weight reduction aspect is a journey, sometimes a long one for some people and plateaus can occur but the glucose control seems to remain functional.
The weight loss function vs the glucose control function are somewhat separate functions.
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3x the dose for 3.1% more weight loss. I’d be curious if there are more side effects at that dose.
2 Likes
LukeMV
#66
I’m curious what name brand they’ll come up with once Retatrutide gets approved in 2026. By the time it gets approved, I will have been taking it for well over a year, since I’ve been on it for 8 weeks now, at a low dose.
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Davin8r
#67
The only people taking these oral versions are unfortunate suckers who don’t know any better. I know because I was one, although I used the Henry Meds money back guarantee to get a refund since it was completely useless and had zero effect.
Sema and tirz too big to be absorbed across the oral mucosa and are rapidly and completely broken down in the stomach (unless there’s a special patented absorption enhancer called SNAC technology in the case of Rybelsus, which allows a small fraction to be absorbed directly across the stomach wall). Don’t waste your money on the compounded orals (compounded injectables, on the other hand, have been very effective in my experience).
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https://x.com/cremieuxrecueil/status/1897181887527059669
I’m going to finally stop holding off and inject mine tonight, I’ve had too much disruption from late night hunger
Apparently this one (Retatrutide) helps with lean mass retention relative to Semaglutide. Not sure why, but maybe it has to do with the effects on the liver.
and for me, the lean mass retention is really important b/c it’s not going to be easy for me to regain it.
1 Like
AnUser
#69
Why not, is it the strength training part, or what, if you mind me asking?
I have chronic fatigue (too tired to do things half the time) and ADHD-PI, it makes consistent strength training extremely difficult
but beyond those excuses! The real reason is b/c I want to spend all my time doing knowledge work and it takes away from it.
nearcyan has moderate AGI timelines and uses them to reduce food costs. I don’t need to reduce weight, I just need to reduce how disruptive hunger is to my entire day (i can be hungry enough to eat/drink 9 lbs of food/drink at once, like yesterday when I went from 102->111 lbs (it will go back to 102 very shortly b/c it was ultra-low-calorie, but it’s very disruptive)
Also I have A LOT of noise in my brain (so much theta/delta to alpha/beta ratio) which is strongly associated with ADHD but it makes it hard to focus when doing repetitive things like this beyond the first time
1 Like
