Have you ever felt the need to do this?
Parasites huh? I’ve done a few “parasite cleanses” in the past with herbs, or ivermectin. Not sure if it had any benefit or detriment.
I have looked at fenbendazole and menbendazole, they look quite interesting. Not interested with messing with them right now.
Not sure I’d want to take an antibiotic regularly either. Not gut issues is interesting though. I can’t say I’ve ever had any lingering gut issues from antibiotic usage myself. I’ve only ever used cephelexin.
It is interesting to note doxycycline has only shown positive effects on lifespan in C Elegans. Unsure about other species.
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In this segment of the video David Sabatini talks about using a tacrolimus mouthwash to saturate local FKBP receptors as a possible preventative for mouth ulcers from rapamycin.
I’m curious if anyone here has tried this and how did it go?
It seems as simple as emptying a capsule or dissolving a tablet of tacrolimus into water, shaking well and swishing it around. Likely best timing would be doing it the night before, the morning before dosing and every 2-4 hours for the first day of dosing.
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Yes. I’ve used doxycycline a few times when I get bacterial infections.
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Nlo
#1279
I hear people discussing their side effects while using low dose Rapamycin and wanted to chime in. I started very low and have only worked up to 4 mgs. I seemed to have a new set of changing side effects with each small dose from .5 to 1 to 2 and 4 mg dose: scalp bumps once, female hormone sensations, a lot of fatigue, muscle aches, sleep disturbances, etc. It was odd because others, including a friend on same US generic was consistently having stamina, goal directed activity, and great energy. He was doing so well, he quickly began taking his dose with grapefruit juice. After I decided to wash out my rapa for a few weeks, I returned taking my 4 mgs with lots of grapefruit, and haven’t experienced any side effects at all. Now granted, I’ve only taken two doses like this, so I may have to recant this proclamation, however, I recall reading a number of reports from folks on here that they had less side effects on higher doses than on low doses. Caveat: I have never had the dreaded canker sores, and that is the one side effect that might be dose dependent, so please take my experience with a grain of salt if that’s your main issue. Second caveat: I recently also changed to about 9-14 days between doses which may also help. Not sure about anything, just sharing my experience.
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Beth
#1280
I was worried about this when I first started, so in order to be prepared, I took notes on what some here have recommended….
Here ya go…
Mouth sores
Elros: Triamcinolone Acetonide Dental Paste USP, 0.1%
Rapa admin and attia: debacterol
Joseph Lavelle: methylene blue
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I’ve not found methylene blue to help with the issue but I might not have taken high enough dose.
Debacterol is difficult to procure.
I’ve not heard of that dental paste but I’ve added it to my notes.
If lysine and the hydrogen peroxide mouthwash I’ve ordered doesn’t work I’m thinking of trying tacrolimus mouth wash. Might try that steroid dental paste you mentioned if none of the above make a difference.
When I’m not having these oral side effects this is what I feel.
I’m afraid to up the dose in hopes that the side effects go away.
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CTStan
#1282
My experience is that the ulcers usually resolve on their own in a day or two.
In the situation where they were intractable and becoming very painful, the Peroxyl had dramatic results.
Not a preventive, and probably of no particular benefit unless there are secondary issues.
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Stiv
#1283
I couldnt decide if my muscle aches were my statin or Rapa. I think it’s Rapa.
I also took 9mg once with GFJ and felt really fatigued. Reduced to 7mg this week (Im usually 8mg a week) and much better.
Still muscle aches though so Im trialling no Atorvastatin for a few days.
I also get raised RHR after Rapa and restless sleep. Interestingly I get the same during 72hr fasts so it might be the Rapa-induced autophagy
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Gosh, thank you for this explanation about mitophagy - that makes so much sense! It’s very encouraging, actually. I have just started rapamycin for the first time - this was my second weekly dose, and I noticed the same fatigue. Thank you again! If this actually turns out to be the cause in my case, I’ll look for improvements going forward.
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Just found out mozzies like blood Type O. Didn’t know that, but they used to devour my dad, who had that blood type.
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I’ve started taking rapamycin once a week, begining with 1mg on Sunday afternoons and adding 1mg each week. I reached 5mg at my last dose which is where I was intending to hold it. However, for side effects I’m seeing slow wound healing (a small cut on my hand is taking much longer to heal than normal) and also a significant drop in libido. It reminds of when I take dutasteride or finasteride, except without the awful psychological side effects. I’m considering skipping this week’s dose to see if the side effects dissipate. I am wondering if anyone has noticed something similar and how long did it take the side effects to fade away after ceasing dosing.
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Not a bad idea to take an extra week off if you’re having side effects. No harm in lowering the dose a bit either. It’s not a race.
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Slow wound healing is a common side effect of Rapamycin. I experience it myself. The other side effects are fairly random and varied. Some are beneficial while others are horrible. It depends on your physiology. You won’t know until you try though.
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Fortunately, I have adapted to high-dose rapamycin (more than 10 mg, the effective dose) on a weekly basis.
It’s been about four years since I have been taking high doses. The only side effect I noticed initially was a threshold dose that caused diarrhea. I also noticed slow wound healing. I have never gotten any mouth sores or acne. Initially, I also noticed tiredness the day after taking a large dose. Now I don’t feel any of this, and I don’t adjust my exercise schedule around my rapamycin dose days. Wounds and bites, healing slower? I don’t really notice it, as all minor cuts and bites heal within a reasonable amount of time.
Also, I find no compelling evidence of mTORC2 inhibition at these weekly high doses.
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59vw
#1290
Agree with others that I wouldn’t worry too much about slow wound healing outside of elective surgery where you might want to take a rapa holiday. Rapa inhibits mtor which is going to slow down their division. It’s not a “side effect” it is the direct effect of rapa on cellular metabolism. One reason rapa is used as a chemotherapeutic.
Re Libido that isn’t a common complaint of rapa here. In fact some people claim the opposite. I’m not suggesting your impression isn’t real but you might want to give it some time with the reassurance that decreased libido isn’t a common side effect and perhaps something else is causing it or perhaps it will resolve on it’s own. It’s easy to blame every new sensation on rapa when you first start taking it. My suggestion is to hold steady at your current dose and see how your body adjusts to tolerate it.
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Agetron
#1291
I started out on rapamycin at 6 mg and had great results for a year. Thought more rapa might be better (according to Blagoskylonny) and went to about 12 mg weekly for 7 months - biological markers took an aging hit at that dose, and I would get blocked eye ducts or ulcers - like in mouth only in my lower inner lid.
Since staying at 6 mg no problems. A few days ago decided to up to 8 mg for my LABCORP sirolimus test. Bad idea - next day had eye issues - first time in years. looks like pink eye… feels like a piece of grit in my eye lid. Luckily it seems to be going away after 2 days. No more 8 mg dosing. My sweet spot is 6 mg for now.
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CTStan
#1292
Thats an interesting observation.
Maybe my needs are increasing with age. Twice a month I regularly dose 8mg rapa 1 1/2 hours after a maximum extraction from a grapefruit, (or occasional ketoconazole if I cant get grapefruit). So I estimate an effective dose of at least 4x.= 32mg…
The side effects keep diminishing because in the past they were worse at 6mg plus a booster than they are now at 8mg.
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I believe that was the general thinking of Dr. Blagosklonny.
I have been taking relatively large doses of rapamycin for quite some time, and many of my blood markers have continued to improve. I don’t disagree with @agetron. He is probably taking the proper dose for his age and physiology.
Currently I am taking 6 mg once a week with ruby red grapefruit juice and 10 mg Bioperine, and I put the pills into enteric-coated capsules before swallowing.
At this dose I don’t have any side effects other than less energy on the day after.
Also, I generally exercise on the day after. This, I hope, maintains the peak but reduces the area under the curve. Trying to simulate the curve of Everolimus.
Pulse, but no suppression of mTORC2 and possibly avoiding the rebound effect if I have to stop taking rapamycin for some reason.
It is now convenient for me to get my levels checked at a local lab. But I just have been procrastinating.
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Bob_R
#1294
I was ramping up from 2 mg to 4mg/week then to 6 mg/ week. I got mouth sores first week at 6 mg. The sores were annoying but not severe, I just used Listerine mouthwash. They took a full week to clear, so the next weekly dose I went back down to 4 mg. After that, I went back to 6 mg and have not had them recur after 4 weeks at 6mg, 1x per week.
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Since this post I believe I’ve figured out why I was having side effects.
I had/have pericoronitis, which is a partially erupted wisdom tooth with the gum inflamed and grown over it. Food particles get caught in that area. Rapamycin messes with the immune system somewhat and it left me prone to an infection in the area.
Since then I had been to a dentist and they gave me a special syringe that allows me to shoot warm salty water under the gum every night to wash out any particles. I’ve not had an issue since starting this.
This hopefully will be surgically removed and the issue permanently resolved. Until then, this solution will suffice.
Additionally I stopped using berberine the night before, the morning of and the night of rapamycin dosing to avoid excess inhibition of the CYP3A4 enzyme that can cause rapamycin to concentrate more in the blood or hang around longer. I replaced those doses of berberine with a 500mg extended release metformin.
Metformin also inhibits TGF-β1, which is something rapamycin supposedly activates. This might help further reduce incidence of side effect as TGF-β1 in excess can be negative.
I also have begun swishing methylene blue around my mouth right after dosing rapamycin.
I also have started taking ezetimibe the day before, day of and day after rapamycin dosing.
I tried 2mg rapamycin last week with no issue. I took 3mg today. Next week I’ll take 4mg. My hope is to build up to 6mg a week and sustain this.
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