I ordered some. May as well. I also ordered some lysine which hasn’t arrived yet.
I feel good on rapamycin until I get a mouth sore or some kind of mouth issue, then it just seems to preoccupy my time trying to resolve it.
I’m goin to just reduce my dose to 1mg going forward anyway. I should have started there instead of 3mg.
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Rapamycin makes you weak to bacteria. Therefore using an antibacterial toothpaste like Colgate Total, will probably help prevent mouth and gum issues (but not apthous ulcers).
I’ve heard of people using doxycycline with rapamycin, is this something worthwhile? Or at least have it on hand for a situation like this?
This honestly just sucks. I want to make it work.
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I have several courses of Doxycycline on hand in case I develop a bacterial infection.
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Agetron
#1275
I use 100 mg Doxycycline every few days to kill parasites. No gut issues…recommended weekly by Blogsklonny.
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Have you ever felt the need to do this?
Parasites huh? I’ve done a few “parasite cleanses” in the past with herbs, or ivermectin. Not sure if it had any benefit or detriment.
I have looked at fenbendazole and menbendazole, they look quite interesting. Not interested with messing with them right now.
Not sure I’d want to take an antibiotic regularly either. Not gut issues is interesting though. I can’t say I’ve ever had any lingering gut issues from antibiotic usage myself. I’ve only ever used cephelexin.
It is interesting to note doxycycline has only shown positive effects on lifespan in C Elegans. Unsure about other species.
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In this segment of the video David Sabatini talks about using a tacrolimus mouthwash to saturate local FKBP receptors as a possible preventative for mouth ulcers from rapamycin.
I’m curious if anyone here has tried this and how did it go?
It seems as simple as emptying a capsule or dissolving a tablet of tacrolimus into water, shaking well and swishing it around. Likely best timing would be doing it the night before, the morning before dosing and every 2-4 hours for the first day of dosing.
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Yes. I’ve used doxycycline a few times when I get bacterial infections.
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Nlo
#1279
I hear people discussing their side effects while using low dose Rapamycin and wanted to chime in. I started very low and have only worked up to 4 mgs. I seemed to have a new set of changing side effects with each small dose from .5 to 1 to 2 and 4 mg dose: scalp bumps once, female hormone sensations, a lot of fatigue, muscle aches, sleep disturbances, etc. It was odd because others, including a friend on same US generic was consistently having stamina, goal directed activity, and great energy. He was doing so well, he quickly began taking his dose with grapefruit juice. After I decided to wash out my rapa for a few weeks, I returned taking my 4 mgs with lots of grapefruit, and haven’t experienced any side effects at all. Now granted, I’ve only taken two doses like this, so I may have to recant this proclamation, however, I recall reading a number of reports from folks on here that they had less side effects on higher doses than on low doses. Caveat: I have never had the dreaded canker sores, and that is the one side effect that might be dose dependent, so please take my experience with a grain of salt if that’s your main issue. Second caveat: I recently also changed to about 9-14 days between doses which may also help. Not sure about anything, just sharing my experience.
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Beth
#1280
I was worried about this when I first started, so in order to be prepared, I took notes on what some here have recommended….
Here ya go…
Mouth sores
Elros: Triamcinolone Acetonide Dental Paste USP, 0.1%
Rapa admin and attia: debacterol
Joseph Lavelle: methylene blue
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I’ve not found methylene blue to help with the issue but I might not have taken high enough dose.
Debacterol is difficult to procure.
I’ve not heard of that dental paste but I’ve added it to my notes.
If lysine and the hydrogen peroxide mouthwash I’ve ordered doesn’t work I’m thinking of trying tacrolimus mouth wash. Might try that steroid dental paste you mentioned if none of the above make a difference.
When I’m not having these oral side effects this is what I feel.
I’m afraid to up the dose in hopes that the side effects go away.
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CTStan
#1282
My experience is that the ulcers usually resolve on their own in a day or two.
In the situation where they were intractable and becoming very painful, the Peroxyl had dramatic results.
Not a preventive, and probably of no particular benefit unless there are secondary issues.
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Stiv
#1283
I couldnt decide if my muscle aches were my statin or Rapa. I think it’s Rapa.
I also took 9mg once with GFJ and felt really fatigued. Reduced to 7mg this week (Im usually 8mg a week) and much better.
Still muscle aches though so Im trialling no Atorvastatin for a few days.
I also get raised RHR after Rapa and restless sleep. Interestingly I get the same during 72hr fasts so it might be the Rapa-induced autophagy
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Gosh, thank you for this explanation about mitophagy - that makes so much sense! It’s very encouraging, actually. I have just started rapamycin for the first time - this was my second weekly dose, and I noticed the same fatigue. Thank you again! If this actually turns out to be the cause in my case, I’ll look for improvements going forward.
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Just found out mozzies like blood Type O. Didn’t know that, but they used to devour my dad, who had that blood type.
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