Agetron
#1291
I started out on rapamycin at 6 mg and had great results for a year. Thought more rapa might be better (according to Blagoskylonny) and went to about 12 mg weekly for 7 months - biological markers took an aging hit at that dose, and I would get blocked eye ducts or ulcers - like in mouth only in my lower inner lid.
Since staying at 6 mg no problems. A few days ago decided to up to 8 mg for my LABCORP sirolimus test. Bad idea - next day had eye issues - first time in years. looks like pink eyeā¦ feels like a piece of grit in my eye lid. Luckily it seems to be going away after 2 days. No more 8 mg dosing. My sweet spot is 6 mg for now.
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CTStan
#1292
Thats an interesting observation.
Maybe my needs are increasing with age. Twice a month I regularly dose 8mg rapa 1 1/2 hours after a maximum extraction from a grapefruit, (or occasional ketoconazole if I cant get grapefruit). So I estimate an effective dose of at least 4x.= 32mgā¦
The side effects keep diminishing because in the past they were worse at 6mg plus a booster than they are now at 8mg.
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I believe that was the general thinking of Dr. Blagosklonny.
I have been taking relatively large doses of rapamycin for quite some time, and many of my blood markers have continued to improve. I donāt disagree with @agetron. He is probably taking the proper dose for his age and physiology.
Currently I am taking 6 mg once a week with ruby red grapefruit juice and 10 mg Bioperine, and I put the pills into enteric-coated capsules before swallowing.
At this dose I donāt have any side effects other than less energy on the day after.
Also, I generally exercise on the day after. This, I hope, maintains the peak but reduces the area under the curve. Trying to simulate the curve of Everolimus.
Pulse, but no suppression of mTORC2 and possibly avoiding the rebound effect if I have to stop taking rapamycin for some reason.
It is now convenient for me to get my levels checked at a local lab. But I just have been procrastinating.
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Bob_R
#1294
I was ramping up from 2 mg to 4mg/week then to 6 mg/ week. I got mouth sores first week at 6 mg. The sores were annoying but not severe, I just used Listerine mouthwash. They took a full week to clear, so the next weekly dose I went back down to 4 mg. After that, I went back to 6 mg and have not had them recur after 4 weeks at 6mg, 1x per week.
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Since this post I believe Iāve figured out why I was having side effects.
I had/have pericoronitis, which is a partially erupted wisdom tooth with the gum inflamed and grown over it. Food particles get caught in that area. Rapamycin messes with the immune system somewhat and it left me prone to an infection in the area.
Since then I had been to a dentist and they gave me a special syringe that allows me to shoot warm salty water under the gum every night to wash out any particles. Iāve not had an issue since starting this.
This hopefully will be surgically removed and the issue permanently resolved. Until then, this solution will suffice.
Additionally I stopped using berberine the night before, the morning of and the night of rapamycin dosing to avoid excess inhibition of the CYP3A4 enzyme that can cause rapamycin to concentrate more in the blood or hang around longer. I replaced those doses of berberine with a 500mg extended release metformin.
Metformin also inhibits TGF-Ī²1, which is something rapamycin supposedly activates. This might help further reduce incidence of side effect as TGF-Ī²1 in excess can be negative.
I also have begun swishing methylene blue around my mouth right after dosing rapamycin.
I also have started taking ezetimibe the day before, day of and day after rapamycin dosing.
I tried 2mg rapamycin last week with no issue. I took 3mg today. Next week Iāll take 4mg. My hope is to build up to 6mg a week and sustain this.
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