A ideia, tal como expusemos no nosso Technology Quarterly , Ă© manipular processos biolĂłgicos associados ao envelhecimento que, quando amortecidos em animais de laboratĂłrio, parecem prolongar as suas vidas. Algumas delas sĂŁo familiares, como restringir severamente o nĂșmero de calorias que um animal consome como parte de uma dieta balanceada. Viver uma vida com tanta restrição calĂłrica Ă© pedir demais para a maioria das pessoas; mas os medicamentos que afectam as vias biolĂłgicas relevantes parecem trazer resultados semelhantes. Uma delas Ă© a metformina, que foi aprovada para uso contra diabetes tipo 2; outra Ă© a rapamicina, um imunossupressor usado em transplantes de ĂłrgĂŁos. Os primeiros adotantes estĂŁo começando a retirar esses medicamentos âoff labelâ, por conta prĂłpria ou assinando contratos de serviços com uma nova classe de empresas de longevidade.
Artigo completo: https://archive.ph/2SxZp
Mais artigos e discussÔes aqui: Retardar o envelhecimento estå ficando sério - #3 por RapAdmin
5 Likes
Nothing really new in here,
Artigo completo: https://archive.ph/2SxZp
2 Likes
A full issue on âageingâ
In search of forever
TECHNOLOGY QUARTERLY - SEP 30TH 2023
Slowing, let alone reversing, the process of ageing was once alchemical fantasy. Now it is a subject of serious research and investment, Geoffrey Carr reports
Living to 120 is becoming an imaginable prospect
Artigo completo aqui: https://archive.ph/JWaHl#selection-895.0-895.49
And breaking the paywall a bit⊠the same stories fully accessible:
https://archive.ph/OUCoN
https://archive.ph/FTkkB
https://archive.ph/9hURu
https://archive.ph/ACawU
https://archive.ph/7wUWC
5 Likes
In a serious magazine like the Economist, this is a notable event. The intelligentsia are going to be aware of what is possible, and that will open up new doors. Slowing ageing transitions from the fringe to the elite.
2 Likes
Its interesting - we get more visitors here (mostly readers/lurkers) from London than I think we get from New York City⊠which has surprised me. Perhaps they feel they need to live longer so as to survive the negative repercussions of Brexit 
And, below, a video from The Economist, as part of this series. Rapamycin is well represented but Geoff seems to have more enthusiasm for metformin, which I think is a mistake.
So how you do you classify yourself - charlatan, nutter, or serious scientist? I suspect Geoff Carr would put most of us here in the ânutterâ category.
4 Likes
AnUser
#6
On a good day Iâm a nutter, on a bad day Iâm a serious charlatan. It depends on my mood. 
"Sometimes, greatness borders on insanity vs brilliance. Iâm comfortable on that edge! " - Michael Lustgarten.
If someone doesnât soften their inhibitions every now and then theyâre just going to repeat what theyâve seen on MSM or learned in school and never think outside the box.
1 Like
I try to keep up to speed on the science relating to healthspan/longevity. When it comes to up to date and considered scientific analysis I donât think you can beat Rapamycin.news (which is in part the standard of contributors and in part the sensible moderation from RapAdmin). You cannot really expect a mainstream non specialist outlet like The Economist to get the science up to date and have a good look at the controversies.
A lot of the conferences are the usual suspects going around giving their usual presentations.
5 Likes
I like this paragraph (and the culture is alive and well here)⊠I think heâs talking about us 
Beneath the forest canopy of firms backed by tech royalty an undergrowth of more conventionally financed startups is working on drugs that might slow or stall some aspects of ageing. Even closer to the ground, the idea is catching on of prolonging lifespan and healthspan using pills and potions that are already available, in addition to (and sometimes instead of) the conventional approach of diet, exercise and early-to-bed. A culture of do-it-yourself lifespan extension is emerging, at least in affluent places endowed with the sort of technical expertise and technological hubris identified with Silicon Valley.
Source: https://archive.ph/2SxZp#selection-1063.0-1063.617
5 Likes
I think they are referring there to a geographical location. It would perhaps be interesting to know where on the globe the participants in rapamycin.news actually live or work. My impression is that this forum is global rather than geographical. Perhaps we should set up a mechanism for people to indicate their approximate locations. (ie cities, counties).
3 Likes
Here are some snapshots of where people come from for the site⊠about 90% of visitors are US-based⊠and it drops off quickly after that.
Here is what the âactivity mapâ looks like at a few different times of the day, showing where activity is coming from:
5 Likes
I might be a part of that 'London-lurker" phenomenon 
2 Likes
We are quite spread out.
A show of hands of the NC tribe members? Asheville vicinity?
Another video from The Economist as part of this series on longevity:
2 Likes
blsm
#15
My Midwest US location didnât even make the map!
I just did some screen captures at some various times of the day⊠I just missed doing it when you were on the siteâŠ
And, a new article by the Economist as part of this series below. Nothing really new for people here, but perhaps interesting to see what is being conveyed to a mainstream audience by publications like the Economist.
Full article: https://archive.ph/L26qS
2 Likes
blsm
#17
Indiana, what a sad and lonely state for longevity.
3 Likes
