#181

Thanks, I’ve been taking collagen peptides but I didn’t know if there were treatments more effective at building collagen overtime. For example, I did a CO2 laser about a year ago. I also read a study that rapamycin inhibits collagen production and I have some reservations about that. Tbf my media literacy isn’t the greatest.

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#182

Rapamycin modulated downward cell growth when it is inhibiting mTORC1, so yes, I would expect some reduction in collagen growth during peak rapamycin dosing period, just as you would see less muscle growth (and wound healing) when you are at maximum doses of rapamycin and especially immediately after (the 24 hours afterwards) doing rapamycin.

But, the researchers like Brian Kennedy talk about rapamycin being like a dial that helps turn down mTORC during periods of time, because as people age mTOR becomes more disregulated and the basal (base) level of TOR (the nutrient sensing pathway) trends higher and doesn’t turn down after “nutrition is sensed”. People who are eating excess nutrition (and thus who are gaining excess levels of weight) have TOR turned on a higher percent of the time, and this is why overweight (especially diabetic) people tend to age much faster than people who are calorically restricted. Having mTOR turned on all the time might help with collagen growth, but it also helps with all types of cellular growth including cancers, etc.

I recommend you listen to this video segment: https://youtu.be/dvroImU-1zs?si=bcudZ00-nMEBNmrc&t=402

I’ve not dove deep into the collagen boosting research but I think you are right about lasers (some types of laser resurfacing) helping collagen growth.

Other things (though probably to a much lesser degree) include: 9 ways to stimulate collagen production in skin

Perhaps also of interest: So, what's the deal with collagen?

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How to Reverse Skin Aging
#183

FWIW

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#184

it also inhibits muscle synthesis, and here we are :rofl:
there is organized collagen synthesis and there is disorganized… as we get older everything becomes more chaotic, e.g. monoclonal spikes on SPEP become more common due to plasma cells turning out non-functional antibodies and so on. OLD=CHAOS, rapamycin puts breaks on chaos so order can be restored - sort of as I understand at least

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#185

I guess I don’t understand how it can make people look younger then

#186

This is your aging body without rapamycin.
idiocracy-armageddon

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#187

Actually a pretty good visualization! :slight_smile:

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#188
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#189

Thank you so much for this over the counter recommendation. I’m very, very happy with this product!

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#190

collagen has potential as a weight-loss aid, study finds

Research being presented at the European Congress on Obesity (ECO 2025) and published in the journal Nutrients indicates that collagen could be a safe and effective weight-loss supplement.

Individuals with overweight and obesity who ate protein bars enriched with collagen, a protein that is found in connective tissue, lost twice as much weight as a control group who did not have the supplement. They also experienced greater decreases in blood pressure and waist circumference and saw their liver health improve more. They may also have increased skeletal muscle and fat-free mass.

“Many weight-loss drugs are very expensive,” explains researcher Dr. Paola Mogna-Peláez, of the University of Navarra, Pamplona, Spain. "We were interested in collagen because it is a protein that is cheap and easy to obtain and is not known to have any side-effects. It is also a compound that the public is familiar with.

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#191

All real collagen comes from animals, “vegan collagen” is a contrived mix of related proteins but it is not real collagen.

Collagen is not 1 thing…

I use 2 to 3 types in a blend I make;
Type 1 fish
Type 2 chicken
Type 1 and 3 beef

There are 5 main types of collagen (again all animal sourced) and about 22 variations of collagen

Here’s a breakdown of the main types and their roles:

  • Type I:
    The most abundant type, found in skin, bones, tendons, ligaments, and teeth.

  • Type II:
    Found in cartilage, particularly in joints, and also in the intervertebral discs.

  • Type III:
    Found in organs, muscles, blood vessels, and the skin.

  • Type IV:
    Found in the basement membranes of various tissues, like skin, kidneys, and the lens of the eye.

  • Type V:
    Found in various tissues, including the corneas, some layers of the skin, and hair.

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#192

I wonder what the mechanism of this is. Why does collagen help with weight-loss?
Because glycine helps with satiety? This study seems to indicate that blood-levels of glycine are correlated with feelings of satiety: Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study - PubMed

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#193

It seems we want to buy “Bovine Hide Collagen”…and take it with Vitamin C, at least thats what this guy suggests:

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.

I found this brand is “bovine hide collagen” - perhaps you can find others…

Screenshot 2025-05-15 at 11.25.12 PM
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https://www.amazon.com/Anthonys-Collagen-Peptide-Hydrolyzed-Friendly/dp/B071S8D69C/ref=sr_1_6

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#194

This is hilarious.

image

https://x.com/AviBittMD/status/1952535450649866712#m

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#195

He was actually responding to my tweet here.

What are your thoughts on his response? Let’s discuss.

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#196

There were no significant differences in weight, body mass index, dietary energy and protein intakes between the two groups.

The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial - PubMed

#197

Smart discussion happening on X right now

https://x.com/alexjleaf/status/1952753552956527047?s=46

Tdlr Layne Norton posts new study on collagen showing it’s useless for connective tissue and calls it a scam supplement. Others argue it’s good for skin and debate turns into discussion of collagen on skin health, while everyone agrees it’s useless for connective tissue.

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#198

I’ve always found it weird that Layne Norton has made a personal issue of bashing collagen. The usefulness of collagen for tendon has been proven by numerous RCT on humans notably by Keith Baar’s teams and LN, who claims he only believes RCTs, is clearly wrong here.
Basically you need to take at least 15+g of collagen and some Vit C but then you increase collagen synthesis by around 3 times.
Here is one human randomized, double-blinded, crossover-design study but there are plenty more on pubmed.
Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

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#199

Agreed, seems very odd, Collagen + Vitamin C supplementation around PT post-op is a fairly common recommendation.

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#200

I think I noticed that after I posted it here, a bit of a coincidence.

I was just thinking it would be a huge blunder if the collagen skin studies were confounded by protein intake, at least for the advocates. I haven’t read the study @Virilius posted and Avi doesn’t seem that confident, just a quick review of the literature by him.

Was just mostly about p-values?