You didn’t get the KP.2 2024-2025 booster?

I did get the one that just became available this week. By your questions, it sounds like I am indeed covered for the most current strain! (EDIT: I just googled and there are indeed even newer strains) I was confused by Cronostempi’s comment that made it sound that it was focused on the past strain? See below:

Because the vaccine does NOT address the latest strain, in some ways understandable, as it takes time to adjust the vaccine, and during that time the virus evolves, so by the time the new vaccine is available, it is no longer tailored to the latest strain. Which is fine, new strains don’t matter much on a population level, UNLESS they are extremely prevalent to the point that they substantially displace the strain that the vaccine was specifically tailored to. And that is the current situation in SoCal. The new vaccine has been modified to address a strain that is no longer relevant here.

Of course, one can still gain some protection as the vaccine is closer generationally to the new strain, than for example the previous vaccine. And that’s why I still bother to get it.

The real solution is, as the other poster suggested, to generate a vaccine that focuses on the parts of the virus that doesn’t keep evolving. That allows such a universal strain vaccine to address all the virus strains as it immunizes against the parts common to all strains, the conserved parts which don’t keep changing.

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I looked at a study earlier where the total mortality was observed to be about half for the vaccinated compared to unvaccinated. I wonder about the mental health impact as well. Not only from a reduction in antibodies close to the current circulating variant, but the conspiratorial thinking and feeling a lack of control, believing a shadowy elite behind the scenes is pulling the strings.

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COVID-19 itself has been associated with a higher risk of GBS, as well as other serious complications, making vaccination the safer option for most individuals.

A DNA analysis can give you information about how you might react to Covid. My report said I would likely do worse than average.

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100% agree. Getting Pfizer tomorrow and heading on a European vacation in 2 weeks. I have 2 advanced science degrees, and I too am amazed that those Pfizer trucks rolled out the plant in Dec 2020. Science rocks. Covid sucks. Oh and many of my colleagues are not getting just the sniffles or cold this round. No thank you.

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I haven’t heard of this. Can you elaborate?

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I am getting Pfizer tomorrow and not taking my rapa this Sunday. I’m holding off for a week.

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You could use one of the full sequencing sites, but those are kind of pricey. I believe about $400 and up. Otherwise, if you use Ancestry or 23 and Me, you can download your raw DNA file and run it through https://promethease.com/ for $12. You receive your report in minutes, and it contains a good amount of information with links and citations to expand your research. Ancestry has run specials lately for around $50 with shipping, so $60-65 total is pretty reasonable.

Besides the direct Covid risks in my report, it also said I have an increased risk of pneumonia and lung fibrosis. This was interesting since I had pneumonia 2 or 3 times when I was younger. So, it seemed pretty credible.

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The flaw with this study is that it is an uncontrolled association study. Specifically, it cannot be ruled out the older patients with more severe health issues were more strongly urged to get vaccinated than other cohorts and hence even though they benefited from the vaccine they still had higher total mortality rates than the unvaccinated without severe health issues. Given that Covid-19 mortality was only 9% of the total mortality in this study, any bias in favor of vaccinating those with more health issues would produce the results in this study (higher total mortality rate for those vaccinated)

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I have my 23andme and MyHeritage DNA reports in Promethease. How do you then look for your Covid risk? Their UX is quite bad…

I would recommend Nebula genomics instead, using polygenic risk scores, you can upload DNA data here: Raw DNA upload and analysis | Nebula Genomics

I haven’t specifically looked at covid there or pneumonia though.

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Yes I did Nebula as well and it’s indeed much better in terms of UX and polygenic analysis (Promethease is monogene).

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The government in the US used the covid thing to see how much control they can exert over the
population. Take the mask wearing thing. Science says that masks don’t work for covid. Didn’t stop the government from pushing mask wearing. And democrats, because their team was pushing masks, mostly masked up. That’s why it’s political. I got a covid vax early on because I wanted to travel to see my grandkids. I am 76 and never got covid. I have a good immune system. In light of all the info that has come out about the covid vaccines I would never get another vaccine. There is huge money in selling vaccines and that has been the primary monitor. Big surprise!

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So it’s been a few days since my covid and flu shots (Wednesday), and so far no adverse effects that I can tell. How protective the shots are, is a separate question, but I don’t regret getting them.

As to the “government control” etc., I don’t want to get involved in a discussion as it strikes me as political, which in my experience is rarely productive. All I’ll say on that subject is that - without specifying which side of the argument is which - certain strains of argument involve conspiratorial patterns of thinking, which I don’t happen to subscribe to in general. It is my opinion that you have to look at things from a probability point of view. How probable is it, that a conspiracy is afoot, since that would require thousands of people with ill intent - how plausible so many “evil” people all happen to work for the government? And even if they do, and it is so that these evil or misguided officials exist, fine, granted - then it would require a conspiracy of thousands, and with thousands of people, how likely is it that such a plan would not leak out - highly unlikely I’d say… people can’t keep a secret between just 2 participants, how likely is it that thousands are on code with zero leaks? Smh.

In general, there’s no reason to look for devious malice where simple incompetence is far more plausible. Health policy involves tens of thousands - yes, you will have a huge number of mistakes and incompetents. Have you ever worked for any organization larger than 100 people? Mistakes and incompetence are an inevitability. Incompetence explains missteps far more plausibly than a devious conspiracy involving tens of thousands on code evildoers.

And let’s be reasonable - a sudden massive new pandemic with people dying. It is unreasonable to expect perfect actions from ANY institution or government - you are in a land of uncertainty, so are you really going to harshly judge the response to such a highly urgent crisis that has so many unknowns. There you sit with the benefit of 20/20 hindsight, and say this mistake was made and this and this and this. Golf clap. How wise of you. Of course there will be mistakes, how could there not be?

And just because someone says “gee you should have done X instead of Y” and it indeed transpires that it would’ve been better to do X - consider that you just got lucky, you had as little ground to pick X as Y. You were lucky, not good.

They did the best with the info they had. They had to make guesses, and sometimes they guessed wrong. “Shouldn’t have closed schools, kids don’t get covid” - and early in the pandemic how did we know that kids didn’t get covid? Better safe than sorry. Imagine they kept schools open and thousands of kids died - can you imagine the scandal?? The same folks who are screaming today would be screaming “MURDER!! HOW COULD YOU NOT PROTECT KIDS!!!UNO!”. It was the safe choice. It was wrong. But who knew ahead of time, and which was the safer action - which had a bigger downside in case of guessing wrong? If you guessed wrong and closed schools, you delayed education, bad but far better than guessing wrong and having thousands of kids dead. You choose the lesser of risks, and yes, you might get it wrong, but consider the downsides of being wrong in both scenarios. And you claim instead that they knew but thought “heh, let’s close the schools and have kids disadvantaged, ha, ha, ha, I’ll twist my evil mustache!”… how plausible is that? Which is more plausible - they went for “safety” and were wrong, or they intentionally wanted to harm kids’ education, small business, big business and people’s lives? Again, Occam’s razor - what is more plausible? Conspiracy theories usually die cut down by Occam’s razor. Do you really think there are thousands of officials who dream of nothing more than harming small business and kids? Do you think that politicians of either party are not highly sensitive to the outcry from closed businesses? If they do so, they feel forced by the circumstances. Often they consult specialists in the field, but what do you do when the specialists all conflict? You go with the consensus of expert advice, and yep, sometimes it transpires to be wrong - doesn’t mean they’re intentionally being evil, FFS! Lockdowns and masks, well, how could they know what course of action was right? Some states tried this, others that. Some went by historical precendence - in the huge influenza pandemic of early 1900’s, the cities which locked down and masked up, emerged economically advantaged over those that did not. This time it wasn’t so, but how could they have known ahead of time? They went with the best guess based on historical precedent. Sadly they were wrong - that doesn’t involve evil intent.

That said, were there some egregious sins? Yes. In fact masks - but not as people seem to remember them. I see folks’ historical memory of just a few years is badly flawed. Because the reality is that IN THE BEGINNING Fauci and others LIED about masks. Yes, I used the word LIED. They meant well, but they LIED, intentionally - one of the few instances of such behavior - they thought they lied for a good cause, but lying to the public by health officials is ALWAYS wrong, and that was a terrible, terrible mistake, because you undermine trust which is super hard to recover. Fauci said “don’t wear masks as they are not effective” - THAT WAS THE FIRST policy recommendation. Not “do wear masks”, but “do NOT wear masks” - people who don’t remember this, remember it WRONG. Why? Because Fauci and others were afraid that there would be a run on masks and not enough would be left for doctors and health workers. Remember, there was a mask shortage at the start, so to prevent mass demand, Fauci and others LIED about the effectiveness of masks. Only later did they change their tune - and then officials ran with it and made mandates to the effect “you MUST mask up”. Btw., masks DO work, especially N95 ones, if you look at studies that say “work” and “don’t work”, the consensus is pretty clear that masks work (not perfectly, but well enough to use in practice).

But hey, believe what you want, I know perfectly well that I’m not convincing anyone who believes whatever they believe. I don’t tell you to believe anything - I just give you a helpful tip - whenever you think about some conspiracy, always think deeply about plausibility. How plausible is this, vs that scenario. Which is more likely, from knowing how the world works. And then you’re more likely to reach the truth. YMMV.

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It would be good to avoid using shitty sources and restrict the discussion to scientific papers.

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If only science impacted our lives and our health.

@CronosTempi you need to get ChatGPT to edit your posts to be considerably shorter.

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Or alternatively, you can feed it into ChatGPT and ask it to shorten it. :wink:

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