Honestly, I’d rather get the results in 2029 or 2030. 
3 Likes
adssx
#176
As a reminder, I sponsored selegiline / deprenyl on worms and it failed at 50 µM: Ora Biomedical Million Molecule Challenge Results - #155 by adssx
Is that too high? What would be the equivalent of 0.83 mg/kg/day in mice in C. elegans?
LukeMV
#177
What would the human dose equivalent be of 0.86mk/kg per day? Forgive my inability to know how to convert rat doses.
adssx
#178
Perplexity tells me about 5 mg/day: https://www.perplexity.ai/search/what-is-the-human-dose-equival-l6.d9zFKTYOWjtnS01_IaQ#0
Which is a lot. That’s the Parkinson’s dose. And there’s zero evidence that Parkinson’s patients on selegiline live longer or have any improvements other than symptomatic. People who use selegiline for “longevity” take about 1 mg/day (or 5 mg/week by cutting the 5 mg pill in four to use 1.25 mg/day, 4 days per week).
I wrote this article on Selegiline: Selegiline - Longevity Wiki
5 Likes
LukeMV
#179
Great article. I occasionally check out Longevity Wiki and didn’t realize you wrote for it.
I agree that 5mg daily seems to be high for longevity. I have been taking 1.25mg per day on and off for around 7 years maybe, ever since I read about it in Life Extension magazine. I’m very interested in what more research ends up telling us here.
adssx
#180
I only wrote that article, any one can write anything btw. And it seems that the project is dead.
Anyway, after writing this article I became less convinced about selegiline. Hopefully I’m wrong. Time will tell. I’ll wait to see the ITP results (or anything else convincing) before trying it…
2 Likes
LukeMV
#181
I have to say it doesn’t look too compelling to me after reading it either. Might have a small benefit but I don’t think it will be anywhere close to Rapamycin or Acarbose level.
1 Like
Yes, its rare that you see old research dusted off and restarted… seems worthwhile given what we know: Deprenyl - Anti-Aging Drug Proven Effective in Dogs
3 Likes
Stoked to see glynac especially since they’ve already done glycine alone
2 Likes
LukeMV
#184
I have a feeling we are going to see a really good result here, as long as they use a high enough dose.
3 Likes
I hope they are measuring such that we can rule out my hypothesis that the effect is just from NAC making the food taste bad resulting in caloric restriction
LukeMV
#187
I have a feeling that we will see similar results to what we saw with astaxanthin, i.e. male median lifespan +12%, male maximum lifespan +6% (not statisticaly significant).
2 Likes
I would like to test Harmine and GLP-1 as antagonists for increased insulin production/ potentially increased Beta Cell regeneration. There was a comment above that the ITP does not test injectables. Rybelsus is a semaglutide in pill form – perhaps that can be used?
Would also like to test Berberine.
1 Like
adssx
#190
Oral semaglutide has a super low absorption, that’s why it’s not tested. We need better oral GLP-1RAs and the ITP will test them.
1 Like
Agree we need better oral GLP meds. But to compensate for the poor absorption, Rybelsus pills are dosed far higher than injectables, with the 7 and 14 mg pills supposedly comparable to the two most often prescribed doses of the injectable semaglutide.
1 Like
adssx
#192
I know but I think they’re afraid mice could not eat all of that.
1 Like
How about mifepristone? This study showed lifespan extension in fruit flies - and combining with rapamycin, the combination didn’t do better, implying some overlap in their mechanism of action. It’s the drug used for early-stage abortions (combined with another drug), so with the new administration in Washington DC, I wonder if access to the drug might be restricted.
In regard to it being restricted, this is a state issue, not a federal issue. In my state of TN, everything is extremely restricted. Edited per @ng0rge 's wise advice!
1 Like
ng0rge
#195
Careful…that’s a banned word and so are the “other guys”. I think you can still say “Washington, DC”, but we’ll see how @RapAdmin feels tomorrow.
1 Like
