#1

For some years I had been using Sulforaphane several times a week. Sometimes as Avmacol but mostly with sprouts and heating them to 158 deg F. prior to consumption as per Jed Fahey and R. P. My thought was to increase NRF2 expression, I never thought about being an mTOR inhibitor. I was surprised to read the other day that Sulforaphane is a stronger mTOR inhibitor as compared to Rapamycin. I was unaware of that fact. It would be pretty important to consider if taking both as you may not want to risk overdoing mTOR inhibition as this could be counter productive. I do get some side effects from Rapa (sleep issues, some fatigue and scalp acne). I never had these issues with Sulforaphane. Rapa does seem to really lower inflammation markers to a much greater level than sulforaphane (just looking at bloodwork with CRP), and it also seems to alter WBC counts. I wonder what other peoples thoughts are as to one vs the other. mTOR inhibition is always discussed with rapa but if that is the goal an easy alternative could be SFN.

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#2

Sorry, not answering your question but research BROQ, much higher levels of Suforaphane than Avmacol.

#3

Co-signed on the BROQ being more potent than Avamacol. It isn’t cheap but if you’re just using it three times a week, it’s more cost effective.

I was not aware of its mTOR lowering capabilities but I do think it’s one of the most under-researched supplements with major potential just waiting to be uncovered. I would make the sprouts but I’m a little too lazy to do all that.

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