#1

Its a phase 2 safety study right now although cognitive improvements were noted. Trialed were Serine (Glycine) + NAC + NR + creatine. Targetting GSH improvement using metabolic activators. This combination has already been shown to reduce COVID recovery time significantly.

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#2

. When it comes to NAC It can be used to treat SLE. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus.

(N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial - PubMed)

The study above makes me reflect upon the possibility that NAC might have to reach above a certain threshold to have effect on mTOR. 2,5 gr/day.

https://thescipub.com/abstract/10.3844/ajisp.2014.114.115

There is also observations that ā€œAltered signal transduction; mTOR is activated by relative depletion of glutathione and supplementation of N-Acetyl Cysteine (NAC), a precursor of glutathione, replenish intracellular glutathione and inhibits mTOR signaling and diminished oxidative stress mediated damage in SLEā€.

The above study is relevant to SLE but the thought that low levels of glutathione activate mTOR is relevant to the longevity community and especially to those of us that use NAC+Glycine to normalize glutathione levels. Human biology is complex and one has to be careful not to generalize and translate observations from one context to other without considering risks and rewards.

There is a quite a bit of evidence showing benefits from the use of NAC. My questions are if there is a threshold effect to reap benefits of NAC? And also that oxidative stress is an important regulative signal which make it an attractive hypothesis to provide the precursors to glutathione (NAC-Glycine) and by doing so allowing the different organs/cells in the body to establish youthful levels of glutathione and not overload and distorts the systems with to much antioxidants. And if we by doing so also inhibit mTOR? It is even better. Iā€™d like to see the ITP test NAC/Glycine+Rapamycin.

An interview with Sekhar:

(Our moderator and others are more than welcome to link my reflections to already existing and relevant threads. This since what I write is not only related to NAC-Alzheimers and dr Bradā€™s video above but also to the a general discussion about NAC-Glycine.)

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#3

Great minds think alike. For more information about NAC+Glycine look at the Baylor studies on mice and humans. My parents take both NAC and Glycine and this has helped my mothers diabetes.

I think you need to take more Glycine than NAC. I am taking about 5 g of Glycine and 3 g of NAC daily.

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#4

Like he says there wasnā€™t a statistical significant effect compared to placebo. Meaning there wasnā€™t enough participants in the study to detect an effect that couldnā€™t be due to chance.

However there wasnā€™t any severe adverse events detected. If supplements are chosen for safety, some forms in this study which Dr. Stanfield disagrees with, it is probably a good bet. I wouldnā€™t be running to the supplement store screaming Eureka however.

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#5

What about l-carnitine? I am assuming that you take B3.

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#6

I take L-Carnosine (not carnitine) daily and an all inclusive B complex vitamin once a week.

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