I have wondered this because a few months ago my fasting glucose tested at 70 and my insulin was below the detection threshold. It has been 2.3-2.6 since then.
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Wow, thatās pretty extreme, lol. Any idea what is responsible? Genes, lifestyle, supps, meds?
I think I was legally dead.
ā¦ I will check my records
Edit: @CronosTempi records checked. I was not dead.
7mg of reta a week (not a big deal for me), 0.5mg of cagrilintide a week, 5mg dapagliflozin, 2IU HGH, some aromasin, 500IU HCG every 3 days, a dose of testosterone that will remain private, 5mg ezetimibe, 180 bempedoic acid, 5 mg rosuvastatin every 3 days, 1200 NAC, 20mg telmisartin, 5 mg nebivolol, 250mg ashwaganda, 1000mg curcumin, 32IU oxytocin nasal spray, 1mg thymosin alpha 1, some trazodone, some T3, fish oil, multivitamin. Assorted other supplements that probably donāt do much of anything.
The cagrilintide was the only thing truly out of the ordinary. Simultanous reta + tirz + dapa have not done that to me on other panels. You would think the HGH would have been a minor issue, but no.
I do eat very clean, but I donāt watch carbs at all.
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Thank you. It seems you have a reasonably extensive stack. I donāt think it would be easy (or frankly possible!) for someone with a different stack to replicate your results. Very much an n=1 situation, but interesting nonetheless for someone like me who couldnāt get below A1c 5.7 and morning FBG of 105+ no matter what Iāve tried (so far).
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The stack changes with time (fewer medications now, more research chems), but no, I donāt think any sane person would even want to try. On the other hand, this is rapamycin.news forumā¦ 
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I pretty much mirror about 75% of your stack. I am interested in Cagrilintide. I am diabetic so have diabetic meds. Am looking to increase insulin sensitivity and reduce visceral fat (DNP ? separate discussion).
What was truly out of the ordinary re Cagrilintide. Efficacy? side effects? Effect on Insulin reduction? How did you arrive at the dosage?
Appreciate your input. Thanks. Cheers
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@AgentSmith Do you feel like you are aging slower than a normal person? Do you feel healthy?
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Man you must feel pretty good on all of that!
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Youāre probably seen the recent thread in DNP or maybe you were active there - but I would offer a couple thoughts on that one. Itās notable that I do not see bodybuilders using DNP these days. My coach trains pros and was himself mentored by one guy who placed 2nd in the Olympia and another guy who has trained multiple Olympia winners (no joke!), and they do not go near DNP. These are guys who will use multiple compounds in high doses at once, but they do not go near DNP anymore. Now, you may know that you can get it in tablets from China, but itās pretty high risk. If I were to use it, I would send 3 tablets to Janoshik for variance testing, or I might use a precision balance to measure out powder myself.
Safer alternatives would be tesamorelin, which you can get for about $1/mg from China, or even oxandrolone. But I would start with tesamorelin. That combined with tirzepatide or retatrutide should reduce visceral fat significantly in a deficit.
All that cagrilintide did was make me tired, but most will pair it with semaglutide and I didnāt do that. I was looking for more appetite suppression than I get from retatrutide, and I didnāt want to add in tirzepatide at the time. The dosage was just what a lot of people on forums tended to start with. Some start at half that, but I have a high tolerance for most drugs.
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If you do use DNP, you need to know if you have the crystalline form, and you must be aware of the long half life because it will build.
@Mantheunknown editing this to ask if you have looked at BAM-15 as another alternative to DNP? Itās a bit expensive, but it is safer and gaining in popularity.
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You may want to increase your telmisartan dose of youāre running higher anabolics. I doubt 20mg is enough to prevent cardiac remodeling. I have to go down to 40mg when my cardio is on point, but I can take 80mg without blood pressure getting too low when itās just OK. I donāt seem very susceptible to itās effects though. 80mg takes me from 120/80 to 110/70 normally, and 100/60, which is too low for me, when Iām psychotic on the cardio.
Before offering opinions about someoneās protocol I think itās better to ask more questions. Some of your assumptions about me are wrong.
Hence the āifā in my statements. You just didnāt seem willing to discuss details, so I didnāt want to push it. Sorry to offend.
FYI I run TRT at 300mg, 200mg every 5 days, and I run one 600mg 20 week cycle every other year.
I have tesamorelin. I have not used it yet. Will do it after my current āexperimentsā conclude, and I have testing results. I was planning on adding cagrilintide to my tirzepatide, am currently on 15 mg. I take160 mg of telmisartan. My potassium levels are ok. I too have a fairly high tolerance for these excursions!. Cheers
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I feel heathier than I have in many years, but it has been a slow, steady progression since 2021 when things went downhill for me. Sleep is better than ever, HR is nice and low at night, HRV is improving, mood is pretty good, so generally being in more of a parasympathetic state contributes to feeling healthy. Iāve gotten my fitness to a solid level, that also helps.
What is interesting is that changes in my training (less intensity), adding cold plunge, working on mitochondrial function with peptides and research chemicals, and reducing oxidative stress via some less-popular ways, have moved the needle more than any pharmaceutical medications that Iāve tried.
Am I aging slower? I donāt knowā¦ I guess low cholesterol, low inflammation, good insulin sensitivity, and good body composition are at least markers of lower disease risk, yet Iāve been deliberately pushing mTOR up so Iām sure that is aging me a little faster than ideal and increases my cancer risk. HGH is tricky because I feel so much better on it yet maybe the IGF-1 isnāt good.
I guess the broader question, the one we all wrestle with, is how to find the balance between feeling good / performance and longevity. For me, I take a multi-factorial view that takes my personal temperament and belief system into account, which means my objective isnāt simply to live as long as possible. I donāt fear death - I think I will be much happier in the afterlife and look forward to it - but I would like to be around long enough in good enough health to help my kids and grandkids and as many people as I can along the way. And I do feel better when I look better, so I acknowledge that, accept it, and work towards it regardless of whether it may be a character flaw that might reduce my lifespan.
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Thatās great. If you do try DNP, please let us know how it goes. It sounds like you know how to source it already.
No I do not. I have a precision balance for measuring out. I intend to be on it for a very short duration. Just long enough to remove a pound of fat. Will use DEXA to monitor. No question of allowing it to build up. Will PM you. Thank you. Cheers
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More recently, cold plunge, SLU, NAD+ injections, 5 amino 1mq, SS-31, injectable glutathione, injectable l-carnitine, ,injectable ITPP, and C60 have been the feel good mix.
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I am amazed at your ability to manage all these injections. Maybe they are staggered but still. Cheers
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They are staggered, scheduled, and low dose.
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