Funny - I watched this a month or two ago. Enjoyed the movie, but couldn’t help but think that this would have been a very different movie if the lead character were male instead of female.
I mean - the plot would likely be very different. In this movie - the woman basically self isolates because every relationship she gets into eventually the other person ages out of it - and she stays the same age. The rapidly diverging biological ages means she gives up on the relationship and then at some point decides its not worth it. Her thinking, in the movie, is “why have a relationship if you’re not going to grow old together”.
If guys could stay looking like they are in their mid-20s for their entire lives… while everyone else aged, and therefore they were effectively somewhat constrained to date women in their mid-20s… well, I think many, if not most, guys might consider that a “feature, not a bug”.
Sort of like Leonardo Di Caprio’s dating approach:
This does, however, make me wonder about another possible area of impact of rapamycin.
There is a lot of evidence that rapamycin prevents the weight gain that most people see after the teen years, it also seems to prevent ovarian aging for females, as well aging in many organs.
What would be really interesting to find out is whether rapamycin also helps prevent and slow skin and tissue aging… I mean, if the skin and tissue don’t age and sag, etc. as is typical with aging skin, rapamycin could completely eliminate the need for face lifts, and all the skin care regimens that many people, especially women, adopt to prolong their skin youth.
Rapamycin could be the ultimate skincare regimen in the future. I mean, something that prevents skin aging and facial sagging, is probably as close to a fountain of youth as most people dare to think about - especially women who buy anti-aging skin creams.
I wonder about this… they should do close up photos of all the faces of the mice in this rapamycin clinical trials to see if their faces / skin aging slows as much as their body aging slows.
My hypothesis is that with rapamycin and good sunscreen started in the late 20s most of what people consider superficial skin and subcutaneous tissue aging would be a thing of the past.
I’m not sure of the best way to validate this - but studies on mice and other rodents would seem to be a start. Even better would be to look at the marmoset/primate studies that are underway at UT Health San Antonio. Some dermatologists could go and do a skin biopsy and photographic study of the control marmosets vs. the rapamycin marmosets to see if there is a change in skin, dermis tissue and visible facial / body aging.
Newspaper stories like this would be a thing of the past:
