Over the past couple of years we’re seeing several new companies in the business to consumer space for promoting lifespan, healthspan, and generally the use of extensive testing to achieve early detection or prevent diseases. Here’s a group of 10 that I’ve zoomed in on, will take you through, and contextualize in this edition of Ground Truths.
Read the full article: The Business of Promoting Longevity and Healthspan
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We will probably discuss his new book when it is out (may 6th)
"That takes us back to Bayes’ theorem, the mathematical formula for calculating conditional probabilities. In this case, we’re referring to the prior—need to identify high-risk— because if the pre-test probability is low, the accuracy of the test is substantially reduced. Furthermore, getting hundreds of biomarker results and imaging tests in an individual greatly increases the likelihood of false-positive results.
In my new book Super Agers: An Evidence-Based Approach to Longevity (out May 6th) I lay out an approach for primary prevention of the 3 major age-related diseases: cancer, cardiovascular, and neurodegenerative. It’s about using the remarkable progress in the science of aging, which includes organ clocks (via high-throughput proteomics), epigenetic clocks, a dynamic (modifiable) blood biomarker protein for the brain that is as accurate as a PET scan, better inflammation markers, the need to comprehensively track our immune system (the immunome) and other layers of data I’ve been emphasizing in these Ground Truth essays to define high-risk. With multimodal A.I. we can now determine which person is vulnerable for one of these age-related diseases and when it will likely manifest. The when is important. If you’re at risk for developing Alzheimer’s at age 97 it’s much less concerning than age 67.
We’re entering an era of precision medical forecasting, as I recently reviewed in Science. That will only get more precise and accurate with improved A.I. models, such as the large reasoning models (like Gemini 2.0 Flash, DeepSeek R1, Claude 3.7 Sonnet, OpenAI o3) that have recently cropped up (succinctly reviewed here). Each of the three major age-related diseases takes at least two decades to incubate, giving us a long runway to prevent or markedly delay their appearance. We’ve got extraordinary data on lifestyle factors that are of no or minimal cost and relate to each of the principal age-related diseases. No less exquisite capabilities for surveillance of a person at high-risk for use of advanced imaging and biomarker tracking, and aligned with specific interventions."
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Nick1
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Eric Topol is such an objective and data driven scientist/cardiologist. Will pick up SuperAgers!
That must a thorough review on the Commercial Longevity Scape.
This reminds of how 23andme starting selling these genetic testing kits which were essentially a garbage!
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