#1

Latest article from Gethealthspan.com

This Research Review examines the pivotal role of exercise, particularly high-intensity interval training (HIIT), in reducing levels of cellular senescence and its impact on extending healthspan. Cellular senescence involves the accumulation of dysfunctional “zombie cells” that cease to divide but contribute to chronic inflammation—a key hallmark of aging that accelerates tissue degradation and age-related diseases. The Review highlights recent findings showing that HIIT significantly decreases markers of senescent cells, especially in individuals with higher baseline levels of cellular senescence. It emphasizes the importance of the acute inflammatory response induced by intense exercise as a catalyst for beneficial cellular adaptations, including the clearance of senescent cells. Conversely, interventions that suppress this natural inflammation—such as NSAIDs, cold water immersion, antihistamines, and excessive antioxidant supplementation—may blunt these positive effects

The study examined 2 markers for sénescence and found that both of them significantly decreased both 3 hours and 24 hours after HIIT. The decrease in both markers was over 80%.

This is impressive and seems on par to the decease of senescent cell burden for people that take D+Q.

Here is the article :
Healthspan Research Review | The Crucial Role of Inflammation in Exercise-Induced Reduction of Cellular Senescence

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#2

This statement is not very accurate. NSAID’s suppress prostaglandin mediated inflammation, anti-oxidants neutralize ROS which I guess induce the inflammation, anti-histamines are a single mediator blocker and may at most have a very mild effect on allergic inflammation unrelated to exercise.

Cold immersion is a stressor, personally I cannot do it after HIIT - too much stress on the body - so it can actually induce more inflammation in the short term just like exercise, and be anti-inflammatory in the long term just like exercise.

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#3

Thanks for the interesting share.
I see that the study on HIIT was done on 20-26 year olds who should still have healthy pathways for the clearance of senescent cells. It would be interesting
to see if HIIT had a similar effect of regulating the removal of senescent cells in 60-65 year olds.

Also, It is interesting that the NSAIDS only had an acute phase blunting of senescent cell removal. At 24 hours post HIIT, the NSAID group had a similar up-regulated senescent cell removal ability as the placebo group had. We know that NSAIDS down-regulate mTOR in a similar way (via the AMPK pathway) to Rapamycin and that Rapamycin has a direct effect on removing senescent cells. So perhaps it is the mTOR pathway that explains NSAIDS ability to have this delayed ability to remove senescent cells.

#4

That as I see it is the problem with cox inhibitors in that they suppress the prostaglandin pathways. All of them. (either through cox-1, cox-2 or both).

#5

Yes NSAID’s are cox1/cox2 inhibitors, and there some selective prescriptions like meloxicam that inhibit cox 2 only.