He cites the Cochrane review below, for authority:
This is what the Cochrane review said:
Our confidence in our results
We are not confident in our results. We found limitations in the ways that the studies were designed, conducted and reported; and in some studies, the results varied widely, or were not consistent. Our results are likely to change if more evidence becomes available"
He also cites Kaeberlein’s study found below:
This is what that Kaeberlein study said:
Unfortunately, it is not currently possible to know whether CR-like diets impact biological aging in people (Text Box 2). Unlike mice, controlled studies would need to be performed over many years to assess long-term benefits for lifespan and healthspan in humans. The recent development of various “aging clocks” that accurately predict chronological age, and may soon be useful for predicting biological age, offer the possibility that this question may be addressable in the relatively near future (64). For now, however, the data remain correlative.
One line of evidence often cited to support anti-aging effects of CR in natural human populations comes from studies of Okinawans, who inhabit a small Japanese island and smaller islands in the surrounding archipelago where the indigenous population historically consumed about 20% fewer calories than mainland Japan. Traditional Okinawan diets are very low protein (9% of total calories) and high carbohydrate (85% of total calories) (65). Historically, Okinawans enjoyed the longest life expectancy at birth and highest centenarian prevalence in the world, with remarkably low rates of age-associated diseases, like cancer, heart and cardiovascular disease, and diabetes (66).
Another line of evidence for health benefits from CR comes from the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) studies. These are a series of controlled clinical trials in normal and overweight adults subjected to a 25% reduction in caloric intake over periods ranging from a few months to two years. The results of these studies were generally consistent with improved clinical biomarkers of health such as decreased weight, enhanced insulin sensitivity and glucose tolerance, and improvements in major cardiometabolic risk factors (67).
The CALERIE data are further complemented by uncontrolled studies of people self-practicing CR. Data from individuals self-practicing CR are also consistent with improved age-related health measures including reduced weight and fat mass, lower blood pressure and other markers of heart disease, and improved glucose tolerance and insulin action (68, 69).
I always go to the source studies, because some bloggers are not too faithful to the studies they cite.
Two channels stand out to me, as faithful to their sources. They also explain better than my personal understanding, reading their sources - Eleanor Sheekey and Michael Lustgarten.
