#1

A single dose of the drug, called zilebesiran, can control the condition for up to six months, with few side effects, and could end daily tablets

6 Likes
#2

ALN-AGT-Fact-Sheet.pdf (166.0 KB)

1 Like
#3

RNAi is having a big day today seriously. Blood pressure and cholesterol just became extremely occaisional injections rather than daily pills.

1 Like
#4

The question is, how long until it goes mainstream?

#5

No thanks, few side effects unless you are one of the unlucky ones and then you are stuck with 6 months of side effects

#6

Effect is modest.

Single doses of zilebesiran (≄200 mg) were associated with decreases in systolic blood pressure (>10 mm Hg) and diastolic blood pressure (>5 mm Hg) by week 8;

That is achievable with exercise, and other natural interventions.

#7

“>10 mm Hg” is not “modest”: it’s a massive effect. Indeed: “Most antihypertensive drug lower systolic blood pressure by around 10 mmHg, which reduces stroke and heart failure by about a quarter.” ( Efficacy and toxicity of antihypertensive pharmacotherapy relative to effective dose 50 - PMC )

For people who cannot control their BP with exercise and diet only, it could be a life saver.

3 Likes
#8

https://scitechdaily.com/new-medication-could-help-millions-with-high-blood-pressure/