The Multiomics Blueprint of Extreme Human Lifespan

Since the composition of extracellular vesicles (ECV) has also been linked to longevity25, we performed an additional proteomic analysis of M116 ECVs and compared it to a baseline of younger post-menopausal women (yPM; n=4, ages: 49-65 years). Using an Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) model (Online Methods), we observed proteomic distinctions between both groups

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