I am not myself persuaded that the tests actually provide the information we need to judge health improvements. I do tend to try lots of different tests as I don’t have that tight a budgetary limit (in the sense that at the moment I am doing 2 blood panels a week).
However, I am unhappy with the aggregate costs of TruDiagnostic so I will accept gradually drifting down the leaderboard.
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julsgc
#22
I agree. I can justify its use on an annual basis - but not more. I think there are so many clocks out there and new ones emerging that I’d be more inclined to see what they say. What I do like however, is the change. If we can add something to our protocol and see a change, that seems like useful info. I don’t vary my protocol much so not really useful to do - unless I add rapamycin, then Id be curious what 6 month on that addition would show.
Did you guys hear the podcast with Kara Fitzgerald (New Frontiers in Functional Medicine). She interviewed Dr. Matt Kaeberlein. He had a good synopsis of the state of the aging clocks. I also just learned about an inflammation agin clock that will come out soon too. Work by Dr. David Furman.
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julsgc
#23
Thank you! Happy to answer any q’s that come up and welcome criticism. I think we’re all figuring this out together and we have lots to learn from each other. I will reply, it just may take me a bit. I’m more accessible on IG @juliegibsonclark But will be checking in here as I’m currently researching wether or not to add rapamycin.
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@julsgc Welcome to the site! We’re a friendly group willing to help each other out in any way to live longer. I hope we can be of service to you and your endeavors. 
We’re probably the best source on the web for Rapamycin info.
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A quick way to reduce your facial age on the NOVOS app is to smile. That took 2 years off my facial age. However, smiling added 2 years to my eye age.
The good news, is they’re both below my chronological age. Now I wonder how else I can contort my face into losing a few more years. 
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Rapamycin is quite complex as there are dosing uncertainties as well as timing uncertainties.
You will see these discussions on this forum. I tend to argue for a lower frequency of dosing because the idea is to do a spring clean of mitochondria.
I am currently running blood tests twice a week and a continuous glucose monitor following a large dose of rapamycin a couple of weeks ago. I will post the results of these once things have stabilised back to normal. (and I have the test results)
Rapamycin does change the metabolism whilst it remains in the system and it has a long half life.
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I think the underlying rate of CRP is a good metric for inflammation. You need multiple measurements to be able to exclude the value when infected.
There was an interesting paper recently that looked at the acid-base balance. This was based on a previous one that concluded that age is linked to people being more acidic.
I have also recently tried the GlycanAge test and should get the results of that tomorrow.
DunedinPACE is reasonably reliable, but a problem with most methylation clocks is that they can vary from test to test on the same sample too much.
I think TruDiagnostic’s science is actually quite good, but is limited by the unreliabliity of DNA methylation as a metric.
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I did this test back in 2023 and recently did it again (twice) The first report included details on what the measurements mean, with respect to their algo’s. The newer report is just the numbers with no explanation. My guess is that they want you to sign up for the more detailed explanation.
I did repeat the recent test a few days later with a different/newer picture and got a similar result.
I’m not sure how well this app has been validated but I’m sure there is a fair bit of variability.
Steve_M_face-age_novos_2023-09.pdf (711.4 KB)
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LaraPo
#29
How is your Novos facial age compared to your chronological age?
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I’m 68
I’ve got to get my wife to do this, she is 67 and beats me in every DNAm test so far, so why not beat me in another one LoL!
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ng0rge
#31
Hi Julie, Will be great to have your input here. Welcome! Yes, I posted about the segment with Kara Fitzgerald and Matt on epigenetic clocks (the whole podcast was good) here:
https://mmabrasil.localizer.co/t/new-leader-on-the-rejuvenation-olympics/16618/34?u=ng0rge
In fact, Kara is coming to my little town in Mexico (San Miguel de Allende) tonight to give a presentation, so I’ll get to see her in person.
You’ll find plenty of good information here on all kinds of longevity interventions, not just rapamycin. The site is so vast that much of it is hidden away somewhere in past posts - but it gives you plenty to read in your spare time . I’m currently doing a deep dive on epigenetic studies (preparing a post here) and epigenetics could be the future but it’s still early in the research - there are 28 million CpG sites that could be methylated. The other BioAge clock that looks promising is Teal Omics proteomic clock but it hasn’t been released yet. So much is happening in the longevity research, it’s an exciting place to watch.
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I share your concerns. However, Dunedin Pace, while retrospective, is trained on longitudiinal data of the same individuals, so it hopefully is a rough proxy for the rate of aging. Note that Dunedin Pace has also been found to predict all-cause mortality. My guess is that the Dunedin Pace is more valuable than simple epigenetic age tests, but we still don’t really know what they are measuring or how useful they are.
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I agree with you Dunedin Pace has the most promising data. The other stuff just doesn’t look ready for prime time yet - but may get there.
The secondary issue is having a score that is bad, and you’re already doing everything … no real action points. If you aren’t optimizing everything, and it might motivate you if you get a bad score - sure. The downside if you aren’t optimizing everything is a good score could have you reassured (?falsely, maybe real).
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It will be interesting to see her stats when she completes 1 more test.
Because she does not have the blue check mark and her average is a different number from her best, that indicates 2 tests to date. Her avg is 0.665 and her best is 0.65 which indicates that the other result is 0.68
She has an excellent result so I’d really like to see if she can maintain or improve that with her program.
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