#1

@Ben_Greenfield does a good podcast here with Julie Gibson Clark. Julie is beating Bryan Johnson and Dave Pascoe and many others as rated by DunedinPACE numbers.

You can’t argue with her results, but I wonder how much variation in DunedinPACE numbers are due to genetics vs. environment or actions / supplements, etc. the person takes.

Despite not having a billionaire’s budget, Julie’s aging rate — 0.665 (she only ages 66 out of 100 days) — is remarkable, demonstrating that longevity is within reach for many, without breaking the bank. Unlike many of her counterparts in the Rejuvenation Olympics, her routine is somewhat ordinary. She spends $27 a month on a gym membership and $79 a month on the longevity supplement NOVOS. Julie consumes about 16 ounces of a variety of vegetables daily, snacking on carrots, radishes, and peppers during her workday. She limits the amount of refined sugars and grains she eats, and at least three times a week, Julie uses the sauna for 20 minutes before taking a cold shower.

It would be interesting to see what would happen to her DunedinPACE numbers if she was taking rapamycin.

Show Notes

Some related stories and resources:

Julie’s Instagram:

Julie’s workout schedule

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#2

I really like some of her meals and “concoctions”

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#3

I am not really sure what PACE measures. I think it is something vaguely useful, but my own PACE went up as my epigenetic age went down.

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#4

Here is a image of the Novos longevity supplement (ingredients) product she takes, as mentioned in the 1st post from the interview she did.

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#5

Yes I doubt all this epigenetic aging measurement and dunedin pace will pan out sadly. We don’t have anything prospective. I wonder how long she has been biohacking? She looks like a good fit 55 year old - if she’d have been aging at 0.65 for life we’d expect her to look in her mid 30’s.

I like Novos Faceage as my personal observation has been it correlates very well with actual health outcomes.

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#6

I think a key question is what the function of DNA methylation is.

I think it is part of saving energy by not trying to transcribe Genes that are unlikely to be properly transcribed and it is a bit like the grass that appears on a road that no cars are driving on.

There is also the issue that the methylation of DNA in WBCs is an imperfect representation of all the cells in the body.

I am interested in the results of these tests, but not frequently if they cost USD 500 per test. I have had the trudiagnostic test 3 times (it was a bit cheaper) and I am going to stick at this. I do like the concept of the rejuvenation olympics, but not at that price.

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#7

Even though I like Novos Faceage, I don’t think it correlates with actual health outcomes for the reason it is based only on one’s face appearance: e.g. if I apply a hyaluronic serum as a meso treatment, my face would be evaluated as 25-30 years younger. This doesn’t mean that my whole body and organs suddenly became younger. I use Faceage only to see if a new treatment improved my facial appearance.

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#8

Try that and see if it works … don’t think it will and certainly not more than a few years at best.

@JKPrime It won’t … you can do all the skin treatments you want and you might get a little bit of improvement just on that component of the face age but there is more that goes into it than just the skin, there is structure, sagging, markers around the eyes.

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#9

If one skin treatment makes you 25 years younger per Novos face clock then Novos is quite inaccurate.

#10

Or perhaps people individually sometimes age slower than their own average and sometimes quicker. Hence, over a short time window and even over a year or two aging results may be meaningless and only when averaged over a longer time period like a decade or two are more indicative of rate of aging?

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#11

I’d like to she her compare with and without the Novos.

#12

Here is what Vera-Health.ai says on face age and health outcomes.

I agree with @KarlT on seeing if the Novos supplement has anything to do with her Dunedin pace and then does Dunedin pace actual work prospectively?

The apparent age of an individual’s face can indeed correlate with certain health outcomes. Facial aging is influenced by factors such as genetics, environmental exposure, lifestyle choices, and underlying health conditions. While the perception of age can be subjective, studies have shown that looking older than one’s chronological age might be associated with poorer health outcomes.

Research suggests that individuals who appear older than their chronological age might be at higher risk for certain health conditions. For example, perceived facial age is associated with an increased risk of cardiovascular disease and mortality. Individuals who look older may have a higher risk of heart disease and stroke. Additionally, facial aging, particularly in women, has been linked to lower bone mineral density and an increased risk of osteoporosis. Accelerated facial aging has also been associated with poorer cognitive performance and an increased risk of dementia.

Moreover, facial aging can sometimes reflect underlying systemic diseases. For instance, endocrine disorders or malnutrition can lead to changes in facial appearance. Furthermore, certain genetic syndromes that affect aging, like Werner syndrome, are associated with both accelerated facial aging and early onset of age-related diseases.

It is important to note that while these correlations exist, they do not imply causation. Not everyone who appears older will have health problems, and not everyone with health problems will appear older. The perception of age can vary widely among observers, and facial appearance is just one of many indicators of overall health.

In summary, while facial age can correlate with some health outcomes, it should not be used in isolation to assess health risks. A comprehensive evaluation that includes medical history, lifestyle factors, and clinical assessments is essential for accurately determining an individual’s health status.

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#13

“If one skin treatment makes you 25 years younger per Novos face clock then Novos is quite inaccurate”

It’s not a one skin treatment, but consistent treatments for many years. My point is that the Novos app doesn’t take that into consideration. It cannot distinguish between natural vs artificial face aging. My age is 69, but the facial wrinkles score (because of treatments) is 100/100, which means no wrinkles at all. Therefore, it assesses my age as 35-40. It unfortunately doesn’t make my organs younger.

Novos Faceage was probably designed for natural faces only (no facelift, no other surgical procedures, no fillers, etc)

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#14

Just curious and trying to understand Novos face clock accuracy a bit better- so people who meet you in person and don’t know your age, do they think you are 35-40 ?

#15

Ppl who meet me in person think that I’m under 50. Novos app evaluates only face. Ppl see the whole picture.

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#16

I posted a good article on what DunedinPACE is measuring today, for those who don’t understand the how and why of it. It’s really no different than any of our other blood tests, you can have great BP and crappy cholesterol, perfect WBC and bad HbA1c. Different tests results from different functions.

Like aging, with it’s 12 or 13 Hallmarks, 1 test does not reveal the whole story.

PACE is just one test that with all the data it was developed from is an indicator of potential health and life span. It doesn’t tell you what you are going to die from or what you need to change to stay healthy. For many I can see that it would be irrelevant, especially if one is working on that “one thing” they know is going to kill them, like they have cancer or are at risk for AD because of their genetics, etc.

Our experience is that both my wife and I are on the same programs/interventions, we eat the same food, drink the same water, are close in physical activity, I sleep a lot better than she does, we breathe the same air. She absolutely kicks my butt in all epigenetic tests, including PACE.

So yes, genes and sex make a difference. Those 2 parameters alone show differences in many, many trials. So no one should be surprised if a female is ahead of a bunch of Bro’s…

#17

Thank you!!! I love them. Definitely give them a try.

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#18

I’ve been “bio-hacking” for longevity since 2017 when I first learned about the term - longevity. However, I’ve been bio-optimizing since I was 30 and really seriously in my 40’s when I discovered I had heavy metal poising, despite following what I thought was a healthy lifestyle.

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#19

I agree wholeheartedly. The requirement of 3 tests within 24 months makes this economically prohibitive for so many people - and usually the people that might need the change the most.

JUST FYI - there were 3 tests:
0 months with no NOVOS = 0.76 pace
6 months with NOVOS = 0.68 pace
12 months with NOVOS = 0.65 pace

Please note that the first 6 months I was taking NOVOS (Core and Boost) I was under extremely stressful family circumstances. There were no lifestyle or dietary optimization . In fact I’d say it was in the opposite direction in staying up several nights in a row to make sure my son was ok, and eating whatever, if I ate at all (there were weekly trips to In-n-Out for sure). It was truly the most stressful time of my life. So I attribute 8% slowing of my pace to NOVOS. The 2nd 6 months were calmer, and I implemented all the diet and lifestyle points from my website. I’m not selling NOVOS, just stating the facts.

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#20

Julie - great to have you here, and welcome to the site. Congratulations on your success in slowing your pace of aging, as measured by DunedinPace.

Everyone else - Julie is the person this initial post is all about.

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