Top 5 - Which Currently Available Longevity Interventions Do You Think Are the Best

[Bicep]

You might really enjoy “Idiocracy”. It’s a classic.

[RapAdmin]

I saw @Boldi 's post in the Rapamycin Facebook group today (I don’t check there too much, but found this interesting). He’s still using 17AE and I like his approach to improve absorption. I think I may try this approach this year:

[Boldi]

Thanks! I misspelled the company name in the FB comment. It’s Alfatradiol by Ell-Cranell.

[LukeMV]

Mind sharing the dosages and specific drugs you’re taking for what you listed? (For instance which SGLT2, PDE, dosages, etc)

[Jonas]

@desertshores

Rapamycin
Metformin
Acarbose
Lithium
Atorvastatin

How long have you been on Metformin and why?

[Jonas]

Interesting tidbits on rapamycin low dosing. I post this here because it is a more active thread. David Glass is VP at $REGN, he is a bull on rapamycin.

[forceofnature]

Is there any issue with isopropanol being absorbed through the skin (or any of the other ingredients)

[LukeMV]

Did he get specific on what would be considered low doses?

[Jonas]

No. But he has been working on rapamycin for a long time so he may have some papers out there.

[Joseph_Lavelle]

@Jonas

David Glass

From David Glass (rapa proponent) Twitter feed

“…. Exercise is still the only effective treatment for combatting age-related loss of muscle function (sarcopenia) and frailty. Essential for extending healthspan therefore. Helps everyone.”

[Joseph_Lavelle]

This post was in response to a previous post about access to 1mg dosing of rapamycin …. But no other info was provided

[mondagai]

Edited heavily. Lol, guess I should’t comment when I’m exhausted. I have retained link to the ITP table and included a more accurate statement.

Brief exposure to rapamycin has the same anti-aging effects as lifelong treatment

In the NIA ITP studies it showed significant effects for Rapamycin when started later in life (middle age) but better results when started younger (equivalent to 20 or 30 years in human terms). The ITP studies in mice are much more robust than this study identified above in flies. The NIA also does 3 independent studies at one time, so the results here are the combination of three simultaneous double blind, placebo-controlled studies. That is why the NIA ITP studies are considered the gold standard of longevity results and why single studies by independent groups are less reliable. Here are the exact results (click on the image to make it larger and more readable): [1*5jDjHTVs2Cc_QPymWypguQ]

At least in the ITP lower concentrations in food didn’t seem to reduce median lifespan in an ITP trial (see median LS extension for line item Rapamycin Lo Phase II).

[Jonas]

Larry Ellison is 80 year old, this is a video 3 days ago. He has been on rapamycin for at least 10 years. But I am sure he is also on many other things (being the second richest man). He has spend big bucks in longevity. Anyone can dig out anything that what else he is on would be great.

His diet is very Japanese. Miso and Salmon for breakfast.

Larry Ellison Keynote on Oracle's Vision and Strategy: Oracle CloudWorld 2024

[DeStrider]

Larry Ellison looks like he’s in his 50s. I hope he lives to 150!

[adssx]

So what’s the minimum dose to avoid this? And what should be the starting dose for a ramp up protocol up to the desired dose?

[Joseph_Lavelle]

@adssx Great questions. I asked @Krister_Kauppi to get an answer to the original question in his upcoming podcasts. Your questions should be added to that list.

[CronosTempi]

FWIW, I (male caucasia, 66yo) intend to start rapa at 3mg once a week, based on the PEARL trial, as that one did find some effects in males at roughly that dose. I intend to ramp up to 6mg once a week, from 3mg by 1mg increments every 4 weeks (3mg for 4 weeks, 4mg 4 weeks, 5mg 4 weeks), and stick with 6mg for some time, and then cautiously experiment with higher doses.

[adssx]

Thanks. I understand that the PEARL trial used compounded powder in capsules and not tablets (that I assume you’ll use?). How does on “convert” the mg from the PEARL trial to “tablet mg”?

[CronosTempi]

I’m talking about 3mg equivalent, i.e., if taken as enterocoated tabs. The conversion issue was discussed in the webcast, I think it can be found in one of the threads here.

[John_Hemming]

I think @CronosTempi is correct. In essence because the PEARL trial design was dominated by the placebo requirement it ended up not really saying anything new.