You’re right, there does seem to be a column for no-antidiabetics* in some of the tables

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  1. Exercise (Weights, high intensity cardio 5x/week)
  2. Mediterranean diet with lots of fiber and vegetables
  3. Rapamycin
  4. Acarbose
  5. Rosuvastatin
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Phenomenal response.

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  • Proper BMI, consume calories from proper foods: vegetables, fruits, nuts…
  • Psychological engagement, social contact, hobbies, passions, lust for life etc.
  • Regular exercise, 150 minutes per week of moderate-intensity aerobic activity or 75 minutes per week of vigorous aerobic activity
  • 8hrs of uninterrupted sleep every day
  • Glucose management, A1C
  • Statin, MK-4, MK-7
  • Glycine (ITP recommended)
  • NO Alcohol, NO smoking
  • Cancer screening
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6 of your 9 don’t involve medication. This should be everyone’s goal.

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Perhaps. Alternative view: nonsense. Why? Because those “non-medication” recommendations are givens. “No smoking” - duh. I’m not bagging on the list, it’s a good list, nothing wrong. I’m disagreeing that “no medication should be the goal”. Doing the obvious is obvious. What comes after is what’s at stake: the non-obvious, the hard to discern, perhaps even the controversial. It’s why we’re here. It’s the “extra”. Nobody is going to rush to a Longevity Strategies lecture that involves recommendations to breathe and also eat.

Any hope for meaningful extension of healthspan and lifespan by definition goes beyond the default non-intervention physiology. “Ordinary care”, without medication, maximizes the current potential of your body, so yes we assume you already do this, so that’s not what we are asking about. A look at the board clues us in: “rapamycin news”.

The “extra”, the beyond, necessarily involves medication, so it is the exact opposite of a goal of no medication. “No medication” will not get you beyond “ordinary care”. To go beyond, you have to go out on a limb, you must get supra-physiological help, i.e. medication, genetic manipulation, technological enhancement (f.ex. intraocular lens implants to replace deteriorated natural lenses etc.). That should be the goal, because, yes Virginia, there is no alternative. If you want to move faster between point A and point B, optimizing your running is only going to take you so far and so fast, to go faster and further you’ll need to get help beyond your body, a horse, a car, an airplane, a rocket, an intergalactic wormhole transporter. The cult of the “natural” is a resignation to limits and banal irrationality. There is no virtue in “I take no medications” - you may think you’re signalling that you’re healthy, but from my life extension perspective you are signalling that you have proudly given up on any extension, not just trailed behind in the race, but not even entered the race. You are going nowhere, and your “goal” doesn’t interest me.

If you want to extend health and lifespan, medication is not a goal, it is a necessity on the way to the real goal, life extension beyond the “natural” limits and what can be cooked up over the cave fire. To push forward we must climb down from the trees, emerge from the cave, abandon the cult of non-intervention, and wrestle from nature a longer lifespan than randomly befell us through blind evolution. In other news, on this rapamycin news, the search continues.

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But cave fires are unnatural, we natural humans only eat raw meat that we hunted with our bare hands!

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May I ask, what makes alpha lipoic acid make it ahead of acetyl-l- carnitine for mitochondrial health? What I could find in clinical indications is the reverse order, with CoQ10 being no 1. Maybe I am missing something? Saw something on advice against carnitine if you don’t have a deficiency in it…

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Do you use the HGH daily and what kind of IGF-1 levels do you have? I use 1 IE of HGH 3 to 4 times per week ( before bed on heavy weight training days) and I have my IGF-1 level is always around 230 ng/mL

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I use 2iu of HGH every night before bed (I weigh about 210lbs). My IGF1 was 270 last I checked.

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We see this issue from different perspectives.
I don’t disagree that some medications are helpful but I see them as a bridge to better therapy such as gene therapy.
I see the issue not just from a personal standpoint but from a population view. The majority of Americans would have massive gains in health span from these non-medication interventions. And these interventions would be affordable.
All the medications and supplements you can think of are worthless if you’re diagnosed with stage 4 cancer. The point being, these medications are going to help slow some natural progression, but stop cancer?, heart disease? Dementia? Falls?, accidents?

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Can gene therapies stop accidents?

I agree but for me a bridge to better health from improved lifestyle. My list was (a portion) of my real program but also intended to show that I think supplements and medications are a small piece of the long-term solution. I have the advantage of starting from a position of health. I work to provide signal to my body to adapt into what I want for my active life. I also provide the resources necessary, and try to avoid adding impediments. Rapamycin started as my only Hail Mary …the only thing I do for only longevity…but it confounded me by providing short term benefits.

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Not sure what you are referring to.

  1. Rapa 5 mg weekly
  2. NAC, NMN, Areds2, Melatonin, PQQ ( keep eyesight- preventing my AMD from further progression)
  3. Lifestyle: walk, hike, camp, swim, gym machines, balanced meals with fish and greens, fiber, socialize, hobbies, limit alcohol strict 3 times a week, no smoking, dentist 2x a year
  4. CA, MG, K2, D3 ( prevent further osteoporosis)
  5. Reading and researching health topics, getting preventive ideas to maintain health into old age . That’s how I found rapa.
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Statins can cause accidents in some people:

I remember when they came out (I don’t know, must be decades ago) and my doctor at the time said they saved lives from heart attack but at a conference he went to they said not all cause mortality because of accidents, homocide and suicide. Everybody had a good laugh. He said he read it a few times after that and now he thought it was real. I’m sure the pharma machine has produced a plethora of high quality studies since and it is no longer an issue. But drugs can cause accidents in some people.

Overall statins still lower all-cause mortality in the studies and in the real world. A few persons getting depression does not change that outcome.
Besides, some people have died from mundane things like kissing (Myriam Ducre-Lemay). As long as the risk does not outweigh the benefit, it really doesn’t matter and if you do get side effects, lower your statin dose or change to a different medication.

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  1. Diet: Red meat and whale blubber when I can source it, never vegetables. Vegetables are dumb
  2. Hormones: Anabolic steroids, HGH, thyroid, etc. Gotta optimize bro
  3. Peptides: Untested, Russian, and Chinese made, sourced from the black market. These are key for health, who cares if big pharma dropped them because they were cancer causing in early trials
  4. Supplements: All of them. If Attia, Huberman, Patrick, or anyone on social media suggests a new supplement, I get onboard immediately so I do not miss out the benefits
  5. Vaccines: I never have had and never will get any vaccines. They are poison, a cash grab, and used by the government and industrial pharma complex to control the population.

I call these the “5 Tenets of Health and Longevity.” How many do you follow? Get onboard with all 5 if you want to see 120 with me.

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You need to roast your red meat with butter for that testosterone production brah.

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I assumed you have been accepted by Semo. Anything new and interesting to share from the doctorly world of postings? Is there a rapamycin discussion there for longevity practice?

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