#4

Interested to know if anyone signs up for this and is willing to share the label/contents/concentration information. I like what they’re doing, in general, but making rapamycin more readily available, but I’d rather talk to my primary doctor about it / use his compounding pharmacy.

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#5

I think the basis for trying this is the basic research, not results shown (yet), though people are reporting good results from their solutions… but people are doing many things, and I don’t know how the people’s solutions here compare to that of Healthspan’s.

Related reading:

here: Rapamycin, Autophagy and Hair Growth (New Paper)

here: Rapamycin for Hair Growth and Hair Pigmentation

here; Rapamicina resgata o crescimento do cabelo

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#6

Their treatment starts at $140 a month. Maybe I’m jaded/biased because with the information on this board, I know one can create a plan for a fraction of that.

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#7

Some people here have zero interest in the DIY approach to making these types of solutions, and for them perhaps its worth it to just buy a remade product.

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#8

Yes, you’re right. Maybe they’re the majority. The members here are certainly not the mainstream.

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#9

Well if rapamycin works topically to restore pigment and promote hair growth both on scalp and other body areas wouldn’t it work orally as well? There are many who are using it orally and can comment further. Personally I have been using sirolimus 0.2 % cream topically and orally, 10 mg once a week, for the last 5 years. My observations are as follows: orally no effect or negligible effect on hair growth or pigmentation. For sure inferior in that respect to dutasteride and or minoxidil. Topically appears to at least not affect negatively either pigmentation or hair growth. Maybe benefits it slightly. Again inferior to topical minoxidil and or dutasteride.

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#10

Are you using the topical rapamycin cream on your scalp? If so, how long have you been using it for and how often do you apply it? Thanks.

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#11

Twice a day for 5 years. Once in a morning and then at nighttime. 0.2% sirolimus cream custom compounded by the US based pharmacy. I apply it only to some scalp areas both due to the cost and the fact that I want to compare and contrast results.

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#12

Thanks for the quick reply. 5 years is a long time. I’m assuming you’re applying it to your scalp to treat hair loss. Sounds like you’re seeing little to no new hair growth. If that’s true, why do you continue to apply it topically?

I’ve been applying 0.2% Rapamycin cream with EGCG to my scalp for 3 weeks now. Was hoping to find someone who has achieved the desired results (restoration of hair). I was thinking of microneedling in addition to applying the topical solution.

My plan was to give it three months to see results.

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#13

Why I keep on applying it? My objectives with respect of rapamycin are two fold 1) verify the long term benefits on skin and hair. continue using it unless outcomes are clearly negative 2. hair maintenance and not so much hair regrowth. For hair regrowth microneedling + minoxidil + dutasteride are proven tier 1 methods.

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#14

I have mentioned before but the molecular weight of rapamycin is too large to be absorbed through your skin. I have strong doubts this would penetrate to the hair follicle and have any effect when applied topically.

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#15

There are human studies that show skin appearance improvement with topical rapamycin.

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#16

Yes - the molecular weight of sirolimus is 914.187 g·mol−1

But how do you explain this? Rapamycin May Slow Skin Aging (Drexel U. Study)

and, I spoke with Allesandra Zonari, Chief Scientific Officer for OneSkin, at the Longevity Summit in December - and they see a significant reduction in key cytokines in skin with rapamycin: Highlights from the 2023 Longevity Summit - #4 by RapAdmin

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#17

If you are taking oral rapamycin is there any additional benefit to using topical rapamycin? Or does anyone really know?

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#18

There have been no studies done comparing oral rapamycin and topical rapamycin, or oral plus topical rapamycin (for skin aging or hair growth) so we don’t have any definitive information on this.

But, there is research that supports topical (for skin aging, and hair growth), and there is research showing that the topically applied rapamycin does not get into the blood stream, so it seems like the effects of oral and topical are likely separate, and potentially additive.

I personally do both, oral and topical, and have seen benefits from both independently and combined.

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#19

The fact that there is no detectable rapamycin absorption may be simply due to the low dose (.001% in Dr. Green’s formulation. Wonder if this has been looked at with the higher dose forms available (HYFTOR). Suspect more frequent side effects with higher doses. Concentrations of the home brew formulations are all over the place. Adds to the difficulty of comparing results.

#20

Yes, they were testing 0.001% in this study where they did not find any systemic absorption, but they’ve tested much higher dosing levels in some studies (I’ve not looked closely at the issue of systemic absorption in these studies): Rapamycin May Slow Skin Aging (Drexel U. Study)

#21

How is topical rapamycin dosed? Should it be pulsed like oral use?

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#22

I have tried using 0.05% RAPA lotion on my face and body. But maybe it was due to my body type, my face started getting acne, so after a month, I stopped using it. As for the efficacy? I think the A-alcohols are more cost effective.

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#23

the official study used a very low concentration daily, gethealthspan uses much higher concentration so I personally pulsed it once a week. I stopped using it though because it caused Acne. I am already on oral rapamycin and topical stuff is very expensive, not worth it IMO.

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