Did you managed to lower your ALP using TUDCA?
I have similar numbers:
ALT:16
AST:13
GGT: 8
ALP: 110
bALP: 14

If bone is not my problem it has to be the liver, but I don’t know why my liver is having to produce such a large quantity of ALP?

No I haven’t put much attention to it yet, and I’d wait for NootropicsDepot’s TUDCA.
You could test your vitamin D levels, you might be deficient or something else.

Are they going to release TUDCA? By the way, any idea why none of the most reputable supplement manufacturers sell TUDCA? It only seems to be sold by brands I’ve never heard of, with the exception of Double Wood and Nutricost, neither of which is one of my go-to brands.

Yes, they’re working on it. I don’t know, but MYASD (CEO) have said IIRC that the real TUDCA was expensive, so they were expecting other companies to sell other bile acids disguised as TUDCA. They found a supplier for it though recently at a better price.

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I don’t pretend to know what’s going on, but my wife takes quite a bit of TUDCA, so I started taking it one pill 4 times a week and my ALP went from the 100’s (like yours) to 67 this time. Just did my yearly and put the numbers in Levine and got one of the best I ever have gotten. Actual age 64, Levine age 51. I don’t know if it’s meaningless because I’m cheating on the ALP or not.

I’d rather be 51, but I’ll take it.

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How much TUDCA does your wife take daily in mg? How much is each pill? Have you considered taking more? It would be interesting to see if a higher dose leads to an even lower ALP.

Ora Biomedical tested UDCA and TUDCA on worms btw: Ora Biomedical Million Molecule Challenge Results - #352 by adssx

The results don’t confirm the 2024 Chinese paper: UDCA (ursodiol) / TUDCA for healthspan and lifespan? - #4 by adssx

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Ok, I may have overstated. Just asked her and she takes 2 pills when it hurts. She has done that twice a day, but not usually. But there is a twist.

I bought the body bio, which costs twice as much and has half the TUDCA. Because like I said I’m a bad shopper and I happened to be on fullscript. She says it works much better and she quit taking hers. Hers was the VINATURA, which has 1000mg plus milk thistle. She says it doesn’t work at all. Also it doesn’t smell or taste like bile, which the bodybio does. So there is a big difference in product here according to her.

WOW! wish I had come across this earlier! i.e that weight loss can catalyze? cause? gallstones.

After taking only the "trainer"dose of Rybelsus for about two weeks, had severe back pain, and ran sky high WBC. A CRT showed incipient gallstones and there may have been a small kidney stone passed.

I associated this with the Rybelsus, but now I see that it was the weight loss (went from 104 to about 97 in just a couple of weeks) might well have been the absolute causal.

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