adssx
#291
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury 2025
UrolithinA attenuates NLRP3 inflammasome activation and pyroptosis in microglia.
UrolithinA alleviates NLRP3 Inflammasome Activation and Pyroptosis by Promoting Microglial Mitophagy.
UrolithinA alleviates NLRP3 inflammasome activation and pyroptosis by promoting the activation of autophagy in spinal cord injuried mice.
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Every now and then I look at the bottle of Double Wood Urolithin A I bought, but haven’t yet used, and wonder about it. If you’ve been taking it, do you think it’s the real thing?
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Doublewood is a good manufacturer. The supplement is probably the real deal. I just wonder if it moves the needle for longevity.
On my long list of things to test I want to see if a high dose of UA moves the needle on glucose/WBC etc. If it inhibits mTOR then it should have the same effects as Rapamycin.
My assumption at the moment is that it does the same as Rapamycin, but at a much lower intensity.
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Please let us know the results of your experience with it!
I will do, but I have a long list of things to try. It has a half life of under a day which in some ways makes it better than rapamycin as the period of vulnerability to infection is shorter.
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adssx
#297
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adssx
#298
Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity 2025
The findings suggest that changes in cognitive function linked to schizophrenia are driven by the interaction among neuroinflammation, neurogenesis, and synaptic plasticity and that UA has the potential to reverse these processes. These observations provide evidence for future clinical trials of UA as a dietary supplement for preventing schizophrenia.
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Great read, I hope there will some human studies some time soon
adssx
#301
Swiss company Timeline has launched Mitopure Gummies: First-of-Its-Kind Longevity Gummy Launched - Timeline
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Beth
#302
@adssx My friend just tried these and said they were yummy. She also stopped after 3 nights due to having the worst sleep of her life all three nights.
I shared that I had read about that happening to others, and if I recall, one of them was you.
I still have not tried them but am always curious!
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adssx
#303
According to @John_Hemming 's theory that means they’re working and sleep disturbance should stop after a few days or weeks.
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Yes, if they are causing additional autophagy that is expected to raise issues with sleep.
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Nlo
#305
Thank you for this explanation, John. I have had sleep disturbances with rapa and wondered if this was a negative, signifying that I was in the category of people who would not have benefits from Rapamycin. Given your theory about UA sleep disturbances being a sign of autophagy, would you extend that same theory to sleep disturbances with Rapamycin?
If so, is this mostly conjecture or is there data to support this theory?
Third question, how do you explain the many people who immediately have great sleep and energy with Rapamycin? Do you think that they have less cellular debris to auto phagocytose? And did I understand that eventually people will regain their sleep while taking the UA gummies (and/or Rapamycin)? Sorry to pepper you with so many questions, but I’m very interested to learn.
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There was paper that linked autophagy to the disruption of circadian proteins. I have had a quick search, but not found it. I have probably posted it previously.
It appears that this is temporary. Sleep is quite a complex process which can be affected in many different ways.
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Why would you think they increase autophagy? Have you seen any studies indicating that urolithin A can increase autophagy in vivo?
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Not sure what the “they” is here.
There was a paper (and I don’t mind trying to find it, but it is not that easy to find) which said autophagy caused the disruption of circadian proteins
I have done a bit of experimentation with high dose UA which seemed pretty futile unlike high dose rapamycin.
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Sorry for the confusion. “They” was not the best word, I should have said “it”. I was referring to Urolithin A since I took your comments above as if you think that increases autophagy and am wondering why.
Regarding autophagy disrupting circadian proteins, I’m not questioning that as being true.
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UA may help, but it is not on my list of autophagy agonists. I tried quite a high dose earlier this year and it did not seem to move the needle. Its one of those things that may be helpful, but not that useful.
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