Jonas
#1
Elon posted this, anyond want to give a go and report back here?
https://x.com/elonmusk/status/1866469246924157008
Jonas
#2
Gork as AI Doctor? It works! Upload my blood work, reported back within second.
Personally, I like my INR (0.9) a bit higher as well as my Neutrophils (2). I am considering add a baby aspirin. @DrFraser ?
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I think I’d look to the USPSTF guidelines on aspirin. In general, unless you’ve got established cardiovascular disease or history of TIA/stroke.
As there is some evidence that aspirin diminishes colorectal neoplasia, if you are at high risk … possibly consider. But looks like people who are doing this for primary prevention, on average get hurt not helped by taking aspirin.
If you are worried about blood clotting (which I wouldn’t based on INR of 0.9) just making sure you have adequate Omega 3’s tends to prolong bleeding time.
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Of course, I am old enough to have lived when aspirin was the primary pain reliever.
“Take two aspirin and get some rest.”
The benefits of aspirin are numerous.
I think the dangers of taking aspirin are overblown. Just monitor your bloodwork and look for dark stools.
The long-term use of aspirin reduces both the incidence and mortality of colorectal cancer. I can attest to this. I think because I have been a lifetime user of aspirin, my colonoscopy came back clean, zero polyps.
To help prevent gastrointestinal (GI) bleeding in individuals taking aspirin, several medications and supplements can be considered:
- Proton Pump Inhibitors (PPIs): PPIs, such as omeprazole, are highly effective in reducing the risk of GI bleeding in aspirin users. They work by significantly reducing stomach acid production, thereby protecting the gastric mucosa. The American College of Cardiology, American Heart Association, and American College of Gastroenterology recommend PPIs for patients at high risk of GI bleeding who require antiplatelet therapy.[1-3]
- Histamine-2 Receptor Antagonists (H2RAs): H2RAs, such as famotidine (Pepcid AC), can also reduce the risk of GI bleeding, though they are generally less effective than PPIs. They work by blocking histamine receptors in the stomach, which decreases acid production.[1-2]
- Misoprostol: This medication is a prostaglandin analogue that helps protect the stomach lining by increasing mucus and bicarbonate production. It has been shown to reduce the risk of GI bleeding, but its use is often limited by side effects such as diarrhea.[4-6]
- Mucoprotective Agents: Other agents like rebamipide and eupatilin have been studied for their protective effects on the gastric mucosa. However, their efficacy is generally considered lower compared to PPIs and H2RAs.[4]
- Helicobacter pylori Eradication: For patients with a history of peptic ulcers or GI bleeding, testing for and eradicating H. pylori infection can reduce the risk of recurrent bleeding when taking aspirin.[2]
Patients should discuss these options with their healthcare provider to determine the most appropriate strategy based on their individual risk factors and medical history
“The percentage of people who take aspirin and experience gastrointestinal (GI) bleeding varies depending on the study and population. According to a meta-analysis published in the BMJ, gastrointestinal hemorrhage occurred in 2.47% of patients taking aspirin compared with 1.42% taking placebo, resulting in an odds ratio of 1.68 (95% CI: 1.51-1.88). Another study published in the Journal of Gastroenterology and Hepatology found that 4.64% of aspirin users developed GI bleeding over a long-term follow-up period. [1-2]”
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I’m sure it produces some reasonably results for healthy people in regular situations; but I’d worry about the edge cases and more complex situations. But its moving forward…
Predictions are that this is the future for most of us:
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I’d be really cautious on use of PPI’s and H2 blockers. PPI’s are significantly associated with neurocognitive decline and osteoporosis, H2 blockers less so. Both impact (PPI’s more) your nitric oxide cycle - as cruciferous veggies and beets require an acidic environment to then serve as a source for nitric oxide as we get older and there is waning of our nitric oxide synthetase.
I personally think the USPSTF is a dispassionate and conservative group, which is exactly what we should want. Looking at risks and benefits … and I think their advice reflects best current information.
Please note on the TIMI score for likelihood of chest pain being cardiac, use of aspirin increased that risk … maybe confounded, but primary prevention has aspirin not indicated, including in diabetics.
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Jonas
#8
How about taking Asprin with your meal? Would that reduce bleeding risk? 81 mg really is not much?
KarlT
#9
The best way to reduce the risk of medication is to not take medications that don’t have proven benefits.
The problem with using AI comes down to GIGO. It always surprises how many patients present with a primary complaint (symptom) that isn’t really related to their actual problem.
And, yes, I realize as a physician I will soon be replaced by AI.
What ties all this together, is what will AI say when you tell it you’re taking a medicine you don’t need because you think it will make you live longer?
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