Looks like a big effort:
Pretty interesting. Quote:
“These benefits included reductions in systolic and diastolic blood pressure, overall cholesterol, hemoglobin A1C—a marker of type 2 diabetes—and fasting blood glucose and insulin.”
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The paper: Modifiers of the Effects of Vitamin D Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
favorable effects on systolic blood pressure (SBP; −2.04 (−3.50, −0.59) mmHg; 1 mmHg = 0.133 kPa), diastolic blood pressure (DBP; −3.00 (−3.61, −2.39) mmHg), total cholesterol (TC; −0.12 (−0.21, −0.03) mmol·L−1), fasting blood glucose (FBG; −0.13 (−0.20, −0.05) mmol·L−1), hemoglobin A1C (A1C; −0.09 (−0.13, −0.05)%), and fasting blood insulin (FBI: −7.61 (−11.93, −3.30) pmol·L−1)
It seems statistically significant but 2 mmHg of SBP lowering and 0.09 points of HbA1c lowering: not clinically significant. Basically useless.
On top of that “The benefits of vitamin D were most evident in trials performed in non-Westerners”: I haven’t checked the details of the trial but I’m sure it means “based on weak low quality trials from Iran and China”.
Conclusion: the study can go to the trash.
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I take 10,000 IUs daily to get out of deficiency. 5,000 IUs didn’t cut it. It’s important to not be deficient in Vitamin D. We each have our own unique biologies.
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I think there is an limit on the body’s ability to convert cholecalciferol into 25ohd. I therefore use 25ohd (Dedrogyl) to top up my 25ohd. If I only took 3,000 iu per day of cholecalciferol my 25ohd stabilises around 90 (uk measurements) which I think is 36 in US measurements.
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