We need a different mtor 1 inhibitor

[ORRAPA]

Looking at the mouse studies, a human would need to take 8mg/kg/day or so of Rapa to have an aging effect. Current 6mg/week dosages are at homeopathic levels. Hopefully, no one will take rapa at those high levels, as it would massively suppress your immune system.

Rapa at current levels might have some benefit as an anti-inflammatory, by very mildly suppressing mtor 2 / the immune system. It probably isn’t doing much for your mitochondria.

To get an anti-aging benefit we need something that only suppresses mtor 1 and not 2. Whatever that compound is it’s not Rapamycn.

[adssx]

That’s why @Krister_Kauppi started this: The mTOR Inhibitors Lifespan Project Enters Next Phase

[John_Hemming]

@ORRAPA

at homeopathic levels

That is factually untrue. I personally take higher doses, but at a much lower frequency than most longevity rapamycin users. However, 6mg will have an effect and still be “in the system” at the end of a weekly cycle.

[José]

@ORRAPA

…“something that only suppresses mtor 1 and not 2.”…

mTORC2 is made/created from mTORC1

[SurgDoc]

What is your higher dosing schedule?

Thanks

[John_Hemming]

Second High Dose of Rapamycin topic for results

On September 23rd I took 1 packet of biocon and 2 packets of zydus with GFJ and a bit of pomegranate. The Grapefruit was half eaten a while before the rapamycin and half with the rapamycin. This time I had been wearing a CGM (One+) for a few days before taking the rapamycin. It fell off and I got another, I then used a third on schedule, but it stopped uploading on Sunday and that got fixed part way through Tuesday. It will take some work to produce useful reports from this, but I have already done an average glucose chart. I have excluded the days with part data as they will not have useful averages. The results are skewed a bit by alcohol consumption. Alcohol takes down the average glucose. The results, however, still show a useful pattern of Rapamycin initially driving up the average glucose figure. Interestingly it appears that it is the baseline that moves up moreso than the peaks. The body adjusts to produce more insulin, but the rapamycin fades and so at a point when…

[qBx123Yk]

Personally, I’m waiting on What Mannick’s company has to offer: Pipeline . I’ve seen several interviews where she claims better safety and efficacy. For example, TOR101 only inhibits mtorc1, even up to 30mg/kg in mice. It will be expensive!

See https://www.youtube.com/watch?v=teGD6nrhIas

[José]

@qBx123Yk

…“Personally, I’m waiting on What Mannick’s company has to offer:”…

FWIW…

It will not be "approved " for longevity.
Would be approved for ???

Cost will be several hundred or more per mg.

As posted countless times…

“If you wait until you are ready, it is almost certainly too late.”
~Seth Godin

[qBx123Yk]

It’s all about your risk tolerance, I am just stating mine, not dictating what yours should be.

[RapAdmin]

@qBx123Yk

Personally, I’m waiting on What Mannick’s company has to offer:

Sure, it looks interesting, but its going to be 5 to 10 years before its FDA approved and available commercially, if it ever makes it through the phase 3 trials.