#1

FWIW:

Early returns are promising: New evidence presented Monday for an experimental treatment from Eli Lilly found it could help people lose almost a quarter of their body weight in about 11 months.

The new weight-loss therapies could also provide other benefits, such as improving liver health.

And so on. This will be interesting …

#2

Would love to see bariatric surgery go away. I see so many complications.

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#3

I would like to understand why so many people get so large. Is it just comfort eating combined with having access to a massive amount of food? Is it the food itself? Is it the food ads on tv? What is going on?

#4

Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective

Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now.

Two new drugs for treating obesity are on course to become available in the next few years — and they offer advantages beyond those of the highly effective blockbuster drugs already on the market. The first, called orforglipron, is easier to use and to produce, and it will probably be cheaper than existing treatments. The second, retatrutide, has an unprecedented level of efficacy, and could raise the bar for pharmacological obesity treatment.

“They’re both breakthroughs,” says endocrinologist Daniel Drucker at the University of Toronto in Canada, who was not involved in the recent research on either drug.

Results from phase II clinical trials of both drugs were announced at a meeting of the American Diabetes Association this month and in the New England Journal of Medicine 1,2. Phase II trials provide data on a drug’s efficacy and ideal dosage in a small group of participants.

Acting on appetite

Orforglipron and retatrutide both mimic hormones produced by the lining of the gut in response to certain nutrients.

https://www.nature.com/articles/d41586-023-02092-9

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#5

Too many calories basically.
High calorie breakfast.
High calorie lunch.
High calorie dinner.
High calorie snacks/dessert.

Highly palatable food from restaurants/fast food.

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#6

It’s fairly straightforward. Millions of years of humans learning to take in and store what little food they could find. Now there is plentiful calorie dense tasty food everywhere. The basic instinct to eat and survive is much stronger than the will to be thin.

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#7

Hmmm… this is concerning.

Thoughts??

#8

Interesting. My first thought is don’t trust anything CNN says. Delayed or slowed gastric emptying is known effect of drug. Are they calling this paralysis? Other possibility is that we are seeing a side effect that wasn’t reported before, and now is because of the huge increase in use of the drug. Time will tell.

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#9

Ozempic is trendy, what gets clicks is to find terrible side effects.

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#10

My first thought is don’t trust anything CNN says.

Hahaha… exactly.

But as I remember some on here are looking for weight loss options for longevity… thought this was worth at least a quick mention. Not a headline though. Lol

Buyer - beware!

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#11

Can’t have fat people become thin and healthy now, can we?

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#12

Personally I have done the the real fix… eat less calories… burn off more energy/calories - get reduced stored fat - adipose tissue (gym, walking, etc.). Not a quick fix… slow and steady over years… but it is a permanent fix and once you achieve your weight goal… you can splurge often!

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#13

Anecdotally, it seems to me that when I’m out in public (e.g. on the bus) I’m seeing more people that have very large BMIs (like BMI of 35+) & also young adults that are very large. Is this something that anyone else has noticed?

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#14

This is a serious true epidemic for which I see no fix coming anytime soon. These drugs will help a little in the meantime.

#15

That’s Fox (not CNN) interviewing a physician. The case study is from Texas Tech U.

Gastroparesis is a disease with variable presentations ranging from mild nausea and abdominal fullness to recurrent vomiting and abdominal pain symptoms. 4 The diagnosis requires evidence of delayed GE based on a radionuclide study using an isotope-labeled solid meal for 4-hour duration in addition to the absence of mechanical obstruction. Hence, workup generally includes upper and sometimes lower endoscopies. Prolonged DM (>10 years) can cause GP due to neuronal damage which is irreversible and a result of prolonged uncontrolled blood glucose levels.**3,4 Several medications such as proton pump inhibits, anti-Parkinson’s medications, illicit drugs (marijuana), opioids, and GLP-1 receptor agonists have been associated with delayed GE. It is crucial to identify causative drugs as discontinuation of the drug can result in resolution of the symptoms as seen in the 2 cases described above. However, in diabetics, it can be tricky owing to the fact that both diabetes and GLP-1 receptor agonists (an agent for diabetes management) can cause delayed GE;

Table 1.
Gastric emptying study results.

Before stopping semaglutide 0.5 mg/SC weekly
Time Percentage retained Normal values
1 hour 93% <90% and >30%
4 hours 24% <10%
After stopping semaglutide 0.5 mg/SC weekly for 6 weeks
1 hour 77% <90% and >30%
4 hours 6% <10%

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#16

Obvious thought: diet and exercise don’t have these nasty side effects.

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#17

You found the cure to obesity. Why has no one else ever thought about this before?

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#18

(shrug) Everybody want to be thin, don’t nobody want to lift no heavy-ass weight and not put the donut in their mouth.

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#19

Rather naive to think will power will fix the world’s problems.

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#20

https://scitechdaily.com/scientists-reveal-new-weight-loss-hack-drink-this-berry-juice-every-day-to-burn-more-fat/

Scientists Reveal New Weight Loss Hack: Drink This Berry Juice Every Day To Burn More Fat

Study involved 19 volunteers. They had to have BMI greater than 25 (classified as overweight).

Study in the link below:

We previously demonstrated that 600 g of blackberries per day for 1 week both increases insulin sensitivity, as evidenced by a meal tolerance test, and also increases fat oxidation, demonstrated via a reduction in the respiratory quotient from 24 h of indirect calorimetry [12]. The same observations were not unequivocally reproduced by a mixed-berry intervention [13]. Therefore, anthocyanin type and daily dose require further scrutiny to determine which anthocyanins and at what threshold doses may offer benefit to weight management and glucose homeostasis.

We recently studied elderberry juice due to its remarkably high density of cyanidin-based anthocyanins [14]. In that pilot study, we demonstrated tolerability of 177.5 g of elderberry juice daily for 1 week, and possible modulation of substrate oxidation. Additionally, we also confirmed the prospective anti-obesity effects of elderberry juice powder using a diet-induced obese rodent model [15]. In that 12-week study, rodents fed a 45% fat diet supplemented with 10% elderberry juice powder did not present an obese phenotype compared to the control group [15]. Main findings included a normalized growth curve and body composition and improved fasting blood insulin despite eating significantly more kilocalories and maintaining the same physical activity as control mice. In the gut microbiome, the elderberry intervention increased Bifidobacterium, Akkermansia, and Anaeroplasma relative abundances, suggesting the physical and metabolic improvements are at least partially driven by changes to the microbiome [15].

The objective of this current human study is to determine if the metabolic benefits observed with other anthocyanin-rich berries extend to elderberries. To accomplish this, we performed a short-term controlled feeding study in overweight but healthy adult volunteers in a randomized, placebo-controlled crossover clinical trial. Major study endpoints included blood glucose and insulin response to a high-carbohydrate meal challenge, indirect calorimetry, and profiling of the fecal microbiome.

The findings also corroborate the positive effects of anthocyanin rich berry consumption on blood glucose homeostasis and fat oxidation, where a 24% reduction in the serum glucose area-under-the-curve, and 27% increase in fat oxidation were observed with the EBJ treatment. The findings suggest that anti-obesity effects of EBJ observed in translational research models do extend to humans.

The researchers are so bullish on elderberry anthocyanins, that they applied for a patent.

https://wsu.technologypublisher.com/technology/53952

A cursory search shows that blackberry juice (or powder) is a little less expensive than elderberry juice (or powder).