Does anyone know if everolimus is a more selective inhibitor of mtorc1 than mtorc2 compared to rapamycin?
Ive read that daily sirolimus or everolimus does not fully 100% shut down mtorc1, but does everolimus decrease mTOR more than rapamycin (on an equivalent dose basis, whatever that may be)
I’ve not researched this… for what its worth (perhaps a reasonable starting point for your research) - here is the ChatGPT response:
