What Is Your Morning Coffee Routine?

[DeStrider]

Glycine activates MTOR but it is only a minor effect. Rapamycin limits MTOR in a big way.
The magnitude of effect size is the important factor. I still take glycine even on my Rapamycin days.

[BradAronson]

Inulin necessary if you already eat high fiber healthy meals?

[RapAdmin]

Not sure, but some suggestion that inulin and other prebiotics are valuable for short chain fatty acids.

Inulin, and fructooligosaccharides (FOS), Seem to Boost Brain Function in Older Adults

What’s good for your aging gut may also be good for your aging brain. The first twin study of its kind suggests that taking daily protein and prebiotic supplements can improve scores on memory tests in people over the age of 60. The double-blinded trial involved two cheap plant fiber prebiotics that are available over the counter in numerous nations around the world. Prebiotics are non-digestible consumables that help stimulate our gut microbes. One is called inulin, and it is a dietary fiber in the class fructan. Another is called fructooligosaccharides (FOS), and it is a plant carbohydrate often used as a natural low calorie sweetener. To test the effect of these supplements on the aging brain, researchers at King’s College London enrolled 36 twin pairs over the age of 60. Each duo was randomly split so that one twin was assigned a daily prebiotic in a protein powder and the other was assigned a daily placebo in a protein powder. The twin who unknowingly took inulin or FOS gen…

[RapAdmin]

A good podcast on fiber generally, and short chain fatty acids.

Fiber: The Secret to a Healthier, Happier You? - Science Vs

[Jonas]

Is anyone doing this? You are already in a fasted state.

Considering doing this with 1mg Rapa

[RapAdmin]

see Trying a daily Rapamycin Dose Change

and Daily Rapamycin Microdosing?

and What exactly is the strong argument against daily dosing for rapamycin?

[schotmanb]

1.5 liters of French press coffee with 2 servings of collagen peptides …split between two people; usually done by 8’sh. We do not drink anything caffeinated after that the rest of the day. The collagen is in part to provide glycine to accompany the NAC supplements we also take in the morning.

[Larkamr]

Now I’ve added 7 mushroom blend with lions mane.

[Nick1]

Bryan Johnson published his latest edution of morning routine.
I guess many of us already follow the components like biophotomodulation, meditation and exercise.
Does anyone subscribe to his BluePrint branded supplements?
He claims his aural temparture to be 94.5.
I am going to try checking mine.

My NEW Morning Routine

[Beth]

I take his essential capsule and softgel.

I had switched to buying the softgel components separately and then regretted it and switched back. It saved almost no money and was a PIA to take so many things

Here they are:

[RapAdmin]

I’ve updated my morning coffee routine… with a few more ingredients.

Coffee (Pour over)

• Milk to cool it down a bit
• Inulin
• Collagen Powder
• Lions Mane mushroom powder
• Cacao powder
• Creatine monohydrate
• Astaxanthin powder

In each case, for simplicity, I add a moderately heaping tablespoon of the ingredient and stir. This is typically about 5 to 10 grams of material, depending on the product. I do a flat tablespoon of astaxanthin powder, so around 3 to 5 grams.

I added the Lions Mane mushroom powder about a month ago as I came across it on Amazon and thought I’d try it.

This is also a trial with the astaxanthin. It turns the entire concoction a dark red color. And tends to turn your poops red too. I brush my teeth after the coffee as I get the feeling my teeth could turn red also, if I went on too long with this protocol and didn’t brush my teeth immediately afterwards.

I’ll do a blood test in a few months and report on results.

[AnUser]

I don’t drink coffee. I’m really unproductive.

[DeStrider]

@RapAdmin No TMG or Glycine? Relying on the collagen?

(I assume you’re taking taurine later in the day?)

Also, what Astaxanthin powder do you use? Can you link to it? Are you sure the Astaxanthin is being absorbed by your body as it tends to be fat soluble? Or is that what the milk is for?

[Nick1]

Any reason (besides taste) to go with Cocoa powder vs Cacao powder?

[RapAdmin]

No TMG, and yes, just the glycine from the collagen.

And @Nick1 , sorry my typo - I’m using Cacao powder, from Costco, just because it was available and reasonably priced.

I ordered a multi-kg synthetic astaxanthin sample from a manufacturer (DSM) … so not something most people would want to do. Astaxanthin, Natural vs. Synthetic - Your Thoughts?

Now that you mention it, I may not have enough fat at time of consumption… I just did a search on ChatGPT to see how much fat I would need and it seems to suggest I likely need more…

Yes, astaxanthin is a fat-soluble compound, meaning it requires dietary fat for optimal absorption. To maximize its bioavailability, you should take it with a meal containing healthy fats.

How Much Fat is Needed?

• At least 5-10 grams of fat per serving is ideal.
• Higher-fat meals (15-20g of fat) may further enhance absorption, but diminishing returns exist.

Best Fat Sources for Absorption

• Avocados (Healthy monounsaturated fats)
• Olive oil (Extra virgin, cold-pressed)
• Nuts & Seeds (Almonds, walnuts, chia, flax)
• Fatty Fish (Salmon, sardines, mackerel)
• Eggs (Especially pastured or omega-3 enriched)
• Coconut Oil or MCT Oil (Fast-digesting fat source)

Scientific Basis

• A study showed that taking astaxanthin with a meal containing fat significantly increased blood levels of the compound compared to taking it on an empty stomach.
• Lipid-based formulations (like astaxanthin in oil-based softgels) already improve absorption, but additional dietary fat can enhance it further.

Optimal Timing

• Take with a main meal that contains fat (e.g., breakfast or dinner).
• Avoid taking it on an empty stomach or with a low-fat meal, as absorption is poor under those conditions.

[Nick1]

Got it. I have used Volupta brand from Costco. Apparently its in top 5 brands for low chromium content amongst Cacao podwers.
I also get Cocvitae brand when its on sale. It does taste better.
I would try astaxanthin in my morning protein shake which essentially is Levels Whey Protein+1 tbsp of EVOO+ 1 tsp of cinnamon that way absorption is taken care of.

[Beth]

I love seeing what others are doing, so thank you for sharing.

I have questions!!! For you or anyone!

1. I find the world of mushrooms overwhelming, so is there a stand out reason you chose lions mane vs a blend or another option?

2. I imagine there might not be an answer to this, but does anyone feel that vegan collagen might work. I am taking vecollal and I’m not sure I can get over my ick factor to take the real stuff. I’ve been toying with trying because I keep seeing how good it is for us… I’m just not used to consuming animal products.
   https://www.vecollal.eu/

I currently use the following ‘as seen on rapamycin news’ mushrooms

Ergothioneine Supplement | Real Mushrooms

And tremella because a few have raved about its skin benefits.

[RapAdmin]

@Beth

is there a stand out reason you chose lions mane vs a blend or another option?

I was really just seeing how bad it impacted the coffee taste / mixing ability; and some mild potential benefits: Lion’s mane mushroom compounds found to boost memory and nerve growth in new study

I’d like to use king oyster mushroom powder but couldn’t find any at the time, as that would be higher in ergothionine. But I may try shiitake for the same reason. I eat a lot of shiitake mushrooms too.

From ChatGPT:

Top 5 Mushrooms Highest in Ergothionine (A Powerful Antioxidant)

1. King Oyster Mushroom (Pleurotus eryngii)

• Highest known ergothionine content among edible mushrooms.
• Contains up to 13 mg per 100g (dry weight).
• Also rich in beta-glucans and other antioxidants.

2. Maitake (Grifola frondosa) – “Hen of the Woods”

• Contains high ergothionine levels (~7-10 mg per 100g).
• Also valued for its immune-boosting properties.

3. Shiitake (Lentinula edodes)

• Ergothionine levels range from 5-8 mg per 100g.
• Well-known for its immune and cardiovascular benefits.

4. Porcini (Boletus edulis)

• Wild porcini mushrooms contain 6-10 mg per 100g.
• Among the highest in total antioxidants, including ergothionine.

5. Enoki (Flammulina velutipes)

• Around 4-6 mg per 100g.
• Popular in Asian cuisine, offering neuroprotective benefits.

Other Notable Mentions:

• Cordyceps (moderate levels but high in other antioxidants).
• Reishi & Chaga (low in ergothionine but rich in other bioactives).

[Nick1]

Has anyone tried this? It’s available at Coscto but not sure the amount of Ergothioniene that one pack gets you.

[mccoy]

@Beth

I find the world of mushrooms overwhelming, so is there a stand out reason you chose lions mane vs a blend or another option?

At first the world of mushrooms seems overwhelming, but actually there are only about 12 medicinal mushroom, each one with some outstanding properties. Lion’s mane is the nootropic effects.

Here more than ever the choice of quality products is fundamental, since mushrooms concentrate radioactive particles and elements like germanium.

I ended up choosing more expensive selected products and limiting the variety of mushrooms. Right now one only mushroom.

The choice is individual; one species that is very good for prevention is Reishi, or Ganoderma Lucidum, best a mixture of whole mushroom plus extract.

Lion’s mane for the brain, Cordyceps against cancer, but they usually have more properties each one.