Thank you to Krista Kauppi for posting this chart. So simple, yet seemed to confirm for me a decision about whether to take rapamycin that I had gradually been coming to.
We’re all different, and those differences have been portrayed and summarized with various metrics and descriptors.
Take, for example, the classification of body types (and by extension, metabolism styles and genetics): endomorph, mesomorph, ectomorph. Don’t hear much about this these days but I remember the bells clanging when I first came across this. I recognized myself as an ectomorph–ticked all the boxes: low body mass, long limbs, smaller stature, and even the personality style – sensitive, introverted, preferring quiet. Everything seemed to jibe with the “catabolic” type of body, mind and personality. It’s me to a T. My bullet is likely to be a fall, a fracture, sarcopenia. Not cancer. Added to this the hints from the “antagonistic pleiotrophy” concept: early menopause, lower fertility --the low levels of these early life benefits in fecundity, hopefully offset by the low growth type benefits in later life.
So. Rapamycin. I have held the pills in my hand, but decided not to take them. It just seemed like what it is that Rapamycin does – pushes toward the catabolic – is not a match for what I need. Very hard to reach this decision because the evidence for benefits of Rapamycin are already so compelling.
This paradigm and my conviction about its import for me personally governed my decision to decline other recommended interventions – but that’s a whole 'nother story. I do take a bunch of stuff that seems supportive of my make-up. Creatine HCL, for example.
Where are you on this anabolic / catabolic spectrum, and did it influence your decision about rapamycin or any other interventions?
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Certainly agree… when I dosed high on rapamycin for 7 months… a had a break down in my biology… returning to a moderate dose… had better biological life extension.
Spike in inflammation and aging at higher dose for 7 months… reduced dose less inflammation and less aging.
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“I have held the pills in my hand, but decided not to take them.”
Well, send them to me, I am at the very left of that graph, inflammation flaring up my arthritis so much I can barely do light exercise these days.
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I sent them to my son who is also on the anabolic end of the spectrum.
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Vida
#5
I’m seriously catabolic so I better hold off on the rapamycin for now. Just need to find a way to reverse this first…Thanks for posting that great graphic.
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Nick1
#6
When we are growing, children are in anabolic phase. When we get really sick, body undergoes catabolic phase. When we are in stable health, we are in a homestasis. Even though it is stasis, there is a constant turneover and renewal. This means anabolic and catabolic are in a balance.
Our gut epithelium renews every 7 days for example.
As far as muscles are concerned , this means that, for a person with 30 kg of muscle mass, 300-600 grams of muscle protein could be turned over each day, involving both breakdown (catabolism) and synthesis (anabolism) of muscle proteins.
In a practical sense, this turnover can occur at different rates depending on whether someone is at rest, exercising, or recovering from training. To support muscle maintenance and growth, protein intake that matches or exceeds daily muscle protein breakdown (through diet) is important.
So the graph does inform us how rapamycin fits in Net Catabolic and Net Anabolic stage. But doesnt really inform on homeostatiix phase. Thats where the dosing, cycling etc comes in. Of course, we dont have data driven answers to those questions.
May be there should be voluntary registry be created where all nputs are fed and anomymized for analysis.
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Not sure if it’s that simple as anabolic/catabolic - for example, rapamycin is good for building muscle, which is anabolic. Also good for bone density - maybe not strictly anabolic but you would think a catabolic effect would lower bone density so not catabolic, no?
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taying active is one of the most anabolic things you can do. The body tends to discard what it doesn’t use and will catabolize whatever it needs to—muscle, nervous tissue, you name it.
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