Which supplements do you think are still worth taking?

[Mantheunknown]

Jarrow Formulas - MaculaPF has 9 mg Meso-Zeaxanthin in addition to Lutein and Zeaxanthin (20 and 13 mg resp). Cheers

[Curious]

@Mantheunknown

Jarrow Formulas - MaculaPF

Thanks, but that is sold in soft gel capsuls. I look for it in powder form only.

[Beth]

In looking up meso zeaxanthin, I’m now going down a too deep rabbit hole and have discovered Unibar’s CapsiClear Capsanthin that, upon first glance, might be a powerhouse ingredient for eyes. They also make a meso zeaxanthin, but because I dont find a product, I’m assuming they sell the ingredient to supplement makers… (a guess).

I’m just sharing this in the event anyone already knows about this.

I’ll also tag @CronosTempi who posted a video about meso (that I have not watched yet).

[CronosTempi]

Unfortunately this is one of those kitchen sink supplements, which include things you may not want. This includes 10mg choline, which I don’t want and astaxanthin 4mg, which I also don’t want as I already take 12mg in a different supplement.

@Beth - for meso zeaxanthin there is the Intelligent Formula Vision Defender MZ. Another approach I’ve seen is where they simply incapsulate powdered marigold petals (a common source of lutein and zeaxanthin), and estimate that on average you get a given amount of carotenoids, including lutein, zeaxanthin, meso zeaxanthin and various isomers thereof. Again, in buying supplements, it is extremely important to select a reliable brand, because otherwise odds are extremely high you are not getting what’s claimed on the label.

[vongehr]

I started the under-lip pouches since there seem to be many advantages of nicotine, such as the observation that smokers had been protected from the worst of the effects of covid and also Parkinson. One 8 mg pouch a day. Habit forming? Well, a little, but not comparable to the headache if I don’t get caffeine in the morning.

[DeStrider]

Dr. Kaeberlein's Optispan Podcast Series - Rapamycin and More

Dr. Kaeberlein’s recommended supplements. [My Supplement Recommendations as a Longevity Scientist | EP 17 CLIP]

[BCS]

• Why do you take fisetin (a senolytic) daily?
  Other people proposed taking it for example on 3 days once per month. (And additionally it is in tiny doses in strawberries during summer.)
  Therefore you could cut it from your daily list, but still take it and don’t exclude that substance entirely. So you might still get possible benefits alongside reducing the costs.

→ Weekly not daily
A similar approach as outlined above for fisetin is what I treat many of the supplements I take: instead of daily, I take the recommended daily dose weekly.

My reasoning:

• cost reduction of course,
• fewer danger of possible, negative side effects, but
• still getting some benefits/positive effects of it,
• reduced chance of interference with the multiple other supplements,
• reduced chance of the body getting too used to a substance with possible negative effects,
• I can still raise the doses to daily instead of weekly as I get older, when the substances are perhaps needed in higher doses. (Unfortunately the cleansing of the body (kidneys) might also be worse at older age.)

Thoughts on my reasoning taking many supplements only once per week instead of daily are highly welcomed! Thank you very much in advance!

Examples of supplements that I take only once per week (the “daily” dose):

• MSM
• carnosine
• silica
• glucosamine
• chondroitin
• AKG (AAKG, Ca-AKG)
• quercetin
• milk thistle extract (silymarin)
• artichoke extract
• citrus bergamot
• aged garlic extract
• Lithium
• carrot juice (100 % pure juice, from certified organic agriculture)
• mixed vegetables juice (100 % pure juice, from certified organic agriculture)

Generally cycling:

• ashwagandha
• goji berries
• cherries/~ juice/~ extract
• aronia berries/~ juice/~ extract

→ Quercetin:
Same as fisetin. Do it on special occasions in a reasonable dose for senolytic purpose (cf. trials with dasatinib + quercetin). Other than that cut it off your daily regimen or do it only once per week.
Small doses of quercetin are in many food plants, especially apples, onions etc.

→ What is useful for you/your situation, I cannot say. It depends on your diet/nutrition, age, genetics. You know it.
I personally take a dash of cinnamon powder in my coffee or muesli/oatmeal or shake daily for antidiabetic/blood glucose reduction reasons (though not being diabetic), and every other day aged garlic extract and citrus bergamot essential oil for LDL reduction (too high LDL although not eating meat). But if you don’t have this issue, you won’t need garlic or citrus bergamot.

That being said, I generally would perhaps add taurine and AKG to the daily list. You can just take it in very low doses to keep costs low. I do the same.

[L_H]

@BCS

Thoughts on my reasoning taking many supplements only once per week instead of daily are highly welcomed!

I’m also inclined to go less than daily. The dose response curve for most things is non-linear. And ditto the dose side effect curve. So a low dose is likely to have highest impact per unit taken and low side effect risk.

Another way I look at is: the best strategy us furst avoid all deficiencies. A broad sweep of supplements at a low dose is most likely to achieve that aim.

I take the following weekly or biweekly
methylated b vitamins
vit d, k2
curcumin
boswellia
taurine
rapamycin
rosuvastatin
boron
pycnogenol
ezemitibe
magnesium
choline

[Steve_Combi]

@JuanDaw

Wasabi, beloved on sushi, linked to "really substantial" boost in memory, Japanese study finds - CBS News

Most wasabi is fake. For anyone interested in real wasabi, here is a Canadian source.

https://wasabia.com/

[Steve_Combi]

@Steve_Combi

here is a Canadian source.

Get it before the new 25% tariffs on ALL Canadian goods goes into effect March 4.

Interestingly, this all encompassing 25% tariff is going to be on top of other new 25% tariffs meaning that for steel and aluminum there will be a 50% tariff.

[Beth]

Thanks for the heads up!

We have a housing crisis here, yet a lot of lumber comes from Canada. This is going to hurt so many people.

[Steve_Combi]

@Beth

a lot of lumber comes from Canada

It keeps our beaver population busy

[relaxedmeatball]

For me:

Magnesium oxide - up to 750 mg, which is where my bowels get loose. This is taken for some supplemental Mg, but actually mainly for gut mobility

Creatine - muscle and brain benefits are pretty well described now

Fish oil - I don’t get enough through diet

Vitamin D3 for 6-8 months of the year

A very boring list. I would almost never do plant extracts, herbs etc because there’s no real way of knowing he purity, effectiveness. I’d rather use pharma products which are better studied and where the product quality is controlled.

[Steve_Combi]

@relaxedmeatball

I’d rather use pharma products which are better studied and where the product quality is controlled

Me too I do take a lot of supps though

[DeStrider]

Talking Docs talk about the Vitamin D3, Omega 3s and exercise study.

How to reverse aging - The Power of Epigenetics, Omega-3, Vitamin D & Activity

[Agetron]

Minimum B-12 might not be enough to maintain DNA health…

When I did my first TruMe methylation test… and had a differential of 13 years biological to my chronological age. Anti-aging specialist Dr. Yelena Budoskaya was fascinated by my results. She warned me to up my B-12… because the rapamycin might negatively affect it. Started daily supplementing B-12.

Been a high normal on blood tests for B-12 ever since… past 4 years.

Link: https://scitechdaily.com/scientists-just-found-a-major-problem-with-vitamin-b12-guidelines-and-your-brain-might-be-at-risk/

Check your B-12 often as a rapamycin off-label user.

[DeStrider]

How much B-12 do you take?

[Agetron]

Past 4-years I have used the Spring Valley Walmart Extra Strength B-12. 3000 mcg gummies. Cost around : $17.50.

I take 2 gummies at bedtime. Blood tests says it all. Last test… off the charts.

My number 1123… top normal 1171. Nailed it.

[AnUser]

FYI: B12 isn’t that precise to actually measure B12 levels in tissues… homocysteine and metylmalonic acid (MMA) is required to know true B12 status, and it’s possible to be deficient with normal serum B12.

What are your homocysteine levels? What have you done to reduce it? Why isn't it part of PhenoAge or aging.ai clocks?

MMA and HC can diagnose B12 deficiency despite normal B12 levels: There are two enzymatic reactions that are dependent on vitamin B-12. Vitamin B-12 is required for methylmalonic acid (MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine [9]. Therefore, MMA is clearly more specific to vitamin B-12 deficiency compared to HC. A deficiency of vitamin B-12 at the tissue level can lead to elevation of both MMA and HC [1] even when serum vitamin B-12 concentrations are within the reference values. Elevated MMA and HC levels together have been found to be 99.8% sensitive for diagnosing functional vitamin B-12 deficiency [10], which is defined as elevated MMA and HC levels despite normal vitamin B-12 levels in asymptomatic individuals [11–13]. Therefore, using serum vitamin B-12 testing alone may under-diagnose the deficiency of this vitamin. MMA and HC have been identified as early markers of vitamin B-12 deficiency i…

[Beth]

In this video, he shows the test results for various mag glycinate products.

21 Magnesium Brands Lab Tested | Shocking Results!

The last column shows how much chelated soluble magnesium was in the capsule which is why some are in red, even if the actual mg was present.

Note: out of the red highlighted products, he mentioned Swanson is usually high quality, so this would not change his opinion of the brand.