#678

I add TMG, Creatine and Glycine to my morning coffee.

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#679

All those he sells :slight_smile: I think such a blank list is stupid: you must test and take what is good for you. For instance, high B6 can cause irreversible neural damage: don’t take it if your B6 is already high. Similarly, “omega 3” means EPA, DHA, DPA: which one you need and at what dose probably depends on your baseline and APOE4 carrier status.

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#680

He only sells a multivitamin. I believe the amount of B6 in his is quite low compared to a normal multi. He seems to be on the ball as to what he recommends.

Yes, these are basic supplements that everyone should use. It doesn’t make them less important though.

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#681

That’s my point: not everyone should use that. Everyone is different.

#682

We’ll agree to disagree here. Not as many people are going to get their levels of these basic supplements tested. I’m probably just going to take collagen and hyaluronic acid instead of sending a skin sample into a lab for analysis. For most people, it would be best just to take these supplements at the recommended levels and assume that they need them.

Of course if they measure the related biomarkers, that’s the best case.

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#683

Two rational people cannot agree to disagree.

I’m not talking about a theoretical risk. For instance, we have evidence (from large RCTs, association studies, and anecdotal evidence here) that omega-3 supplements can cause atrial fibrillation, depression, and lethargy in some people. So, one should be cautious with blanket recommendations.

And then there’s the question of the quality of these supplements…

#684

Of course, if you take too much Omega-3 it can cause atrial fibrillation. You can also cause death by drinking too much water. You have to be aware of dosing when you supplement, which is why all supplements come with dosing instructions.

Also, I hope that people would be smart enough to stop taking something if it caused adverse effects such as depression.

Yes, you have to be smart about which supplements and how much you take.

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#685

If you start supplementing with all these, how can you know what is causing what? Even if you only take omega 3, depression might also come later; you might not realize it’s caused by omega 3. By the way, I’ve just emailed Brad Stanfield about omega 3, cognition, and depression to see whether he has an opinion on DHA vs. EPA, APOE carrier status, baseline levels, etc. Hopefully he’ll answer…

I’m not saying that for you but for those reading us here and who might see Brad Stanfield’s video and start buying all those on Amazon without looking at the details. Been there, done that: doesn’t work :slight_smile:

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#686

That’s right, as adssx’s observation is right.
What I try to implement in deciding on supplements is something like Potential individualized bang for the buck (PIBFTB).
Potential because we choose on literature data, individual because we try and extrapolate the literature data to our individual setup, bang for the buck because money is worth something.

The above PIBFTB scheme rules out NMN/NR supplements in my case because they are costly and would not potentially add many benefits to my present regimen of healthy food and exercise. I also tried NMN for a limited time; no effects were observed.

PIBFTB is high for creatine, since I also work out regularly and that’s one of the less expensive supplements around.

In my case, I also rule out protein powder, since even if it is not costly, I prefer to take protein in natural foods and in controlled amounts. In my situation, I do not believe that a very high dose of protein, like suggested for example by Peter Attia, would benefit me. Of course, I’ve tried and seen no glamorous results on myself.

The reasonings are different for each one. My bottom line, it’s all right to listen to Dr. Bradfield’s (and others’) suggestions, but then such suggestions should be filtered according to our own individual needs and knowledge and willingness to spend money.

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#687

From Wikipedia, the free encyclopedia

Aumann’s agreement theorem was stated and proved by Robert Aumann in a paper titled “Agreeing to Disagree”,[1] which introduced the set theoretic description of common knowledge. The theorem concerns agents who share a common prior and update their probabilistic beliefs by Bayes’ rule. It states that if the probabilistic beliefs of such agents, regarding a fixed event, are common knowledge then these probabilities must coincide. Thus, agents cannot agree to disagree, that is have common knowledge of a disagreement over the posterior probability of a given event.

I’ve been interested in Bayesian methods, and the cited theorem seems like an interesting way to reason about the topics we are discussing. But it should be discussed more in detail.

For example, sharing a common prior sounds very unlikely to me, since prior knowledge in the literature on supplements is so vast. So, there may easily not exist any common knowledge between individuals, unless they are both very educated in the specific topic.
An alternative would be to agree to some common knowledge (for example, the most known benefits and side effects of Omega-3s). If so, the common knowledge should perhaps be elucidated at the beginning. Also, the theorem would imply that both parties would update regularly the prior by Bayes’ rule, and this would entail meticulous exam of all the literature published.
Besides, the update may be based on individual observations rather than the mere study of population samples as it happens in the literature. This would result in differing data being added to the updating process.

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#688

Two rational people can, however, agree that it is not worth the effort of trying to analyse the reasons why they disagree to resolve the issue as to where the truth actually lies.

Alternatively people have different priorities and that is a reasonable viewpoint to take or alternatively they balance conflcting evidence in different ways.

People don’t really share a common prior and they do have different priorities.

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#689

l agree with most, with the possible exception of TMG.
Every supplement on the shelf at your health food supplement supplier has papers touting its wonders.
BTW: I take TMG because it is relatively cheap and has theoretical merit.
But it doesn’t make me feel any better, has no noticeable effect on my workout, and has never shown any effect on my bloodwork.

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#690

Have you watched the video?

#691

No, I haven’t watched it, but I’m commenting :man_facepalming: (Sarcasm)

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#692

Charles, thanks for your many helpful posts, including this one. I have taken 30mg of Noopept for 5 days and unfortunately have not noticed anything. I am curious whether you, or anyone else who reads this, has any experience with and/or thoughts on modafinil, kratom, or Nooceptin. I have dabbled with the first two, but have no experience with Nooceptin.

#693

You can’t fix something if it’s not broken.
The first time I took Noopept, I noticed an immediate increase in brain clarity; colors seemed brighter, etc. After the first dose the immediate subjective effects wore off.
I do think it does help with brain fog.

I have not tried modafinil. I have tried kratom, but I do not recommend it. It is overrated in its effects. To get any meaningful effect, you have to take it in doses that are dangerous to your health.

I am not sure what you are looking for, but if it is for age-related memory problems, I would recommend Memantine Hydrochloride And Donepezil combined in one tablet, which I get from India. It takes a week or two to start noticing the effect, but it definitely helps with memory problems.

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#694

Where/who are you buying this from in India?

#695

Thanks! My main concern is not so much memory, as it is the ability to have focused concentration and alertness for a sustained period of at least several hours. I have trouble with daytime sleepiness.

#696

Just use one of the suppliers recommended by Rapamycin News members.

The brand that I am currently using is:

“Compre Rapamicina Online - Lista de Farmácias Confiáveis ”

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#697

Update: Brad Stanfield didn’t answer. He answered a previous email I sent months ago (on another topic), so for sure he got my email. He recommends a supplement (omega 3) that is proven to cause depression even at low doses, and he apparently doesn’t care :man_shrugging:

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