I have to admit that after watching this video I’m less cynical about Bryan’s motivations. I was quite judgmental when I first saw him. But, it’s mainly because it’s all very early. I was concerned, and still am that it will all flame out and people will become jaded, because for all the hype there’s nothing really available that will move the needle yet. But after listening to him here I feel like he has quite a profound take. Personally, I have no problem with him selling products. Just because he’s an entrepreneur I don’t think we can automatically assume he had intentions to monetize his protocol, and that was his ultimate goal. I’ve noticed that people tend to react with heavy cynicism as soon as people monetize. But monetization doesn’t automatically disprove efficacy. I believe he genuinely believes in what he’s doing and that his protocol works. I’m hugely skeptical of that, but just because he decided to offer products doesn’t mean he has an ulterior motive. If Blueprint does improve people’s health then people should have access. He also has everything listed on his website for free so it’s up to the individual whether they choose to buy the products or just follow along at home. I’ve softened my view of him considerably after watching this.
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It’s not just the monetization. It’s the excess. It’s the full on more is better that only serves headlines. The excessive, all at the same time experimentation certainly interferes with his or anyone’s ability to learn from his experiments. He is not stupid so why is he making this mistake? I think I know why. His personal backstory is good PR.
The first 1.5 hours of the interview are not interesting to me. It takes that long before they start to get into what he does. I’ll save the good stuff (I hope) for the weekend.
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The guy made like $300 million from the sale of BrainTree - its not like a supplement business is going to increase his net worth in any significant way - so I really don’t think it has anything to do with his motivation, its probably more just a way to deduct his expenses and keep the entire effort self-sustaining.
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Neo
#258
He showed here that he had blood work that shows he has only a small amount of rapa left after 4 days and zero in his blood after 13 days.
Does that half life curve not seems reasonable / are their reasons to doubt his data on that?
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That zero rapa test was after 13 days. His protocol is for rapa every 7 days. He didn’t show a test for 7 days but it doesn’t look like it would hit zero after 7 days for him. Maybe I’m wrong. Maybe he takes a week off every few weeks. I take rapa every 2 weeks and I take a week off after 4 weeks to avoid any accumulation which I believe (side effects) I was experiencing when I dosed weekly.
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Neo
#260
This might be carefully paired to decrease to improve the total risks / reward of the rapa he takes?
That is what it looked like in ITP (although one can perhaps not statically compare between cohorts).
See also this post from one of the most knowledgeable participants here on the forum @McAlister (McAlister - do you have any thoughts on Bryan’s overall protocol above?)
If you’re still reading (and still concerned), then consider pairing rapamycin with metformin.
Metformin inhibits mTORC1 without releasing negative feedback loops and overstimulating AKT. It stimulates AMPK by inhibiting mitochondrial complex I. AMPK then phosphorylates IRS-1 (Insulin Receptor Substrate 1), whereas rapamycin suppresses IRS-1 phosphorylation. Metformin also inhibits MEK/ERK in the presence of growth factors, while rapamycin activates MEK/ERK by releasing feedback inhibition (Rozengurt et al. 2014) 1. In male NcZ10 mice, combining rapamycin and metformin corrected for their independent downsides (Reifsnyder et al. 2022) 1. Similar results were seen with 4 weeks of combination treatment in male Balb/c mice (4–6 weeks old) (Albawardi et al. 2023).
Was it also discussed elsewhere that Metformin can help increase mTORC2?
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Neo
#261
Ok, yes, you are right - he now does high every 14 days and low dose the week in-between.
Is seems like the curve is exponentially fast decreasing - so he may be getting close to zero - or perhaps having a target to not get completely down to zero and build up some amount.
They probably do have the data - hopefully we can see that in the future - might be discussed after he has done the increased lower in between dose experiment.
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Thank you for posting this video. I probably would have missed it.
I am still watching because I can’t watch a 2-hour and 34-minute video in one setting.
But so far I am impressed by his intelligence and I am already changing my mind about him.
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He wrote that he is increasing the “low” dose week to 9mg.
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Neo
#264
Perhaps, but there does seem to be a lot of logic, data and N=1 (and probably other of Oliver’s clients) testing whenever parts of his protocol are discussed.
Most of the “100” pills he takes are kind of stuff we can get from food, like aged garlic, etc and don’t seem that risky?
Still, I agree that he is aggressive on the pharmaceutical side too.
But it does not seems to be the kitchen sink approach - he is for instance not doing some of the top favorites on this forum - SGLTi, Mitopure/UA, DAV, etc, as far I can tell?
I read somewhere that he is trying to answer the question:
- what if control of aging already is possible - but with the totally of the knowledge needed spread out among many hundreds of thousands different papers and studies - but holistic protocols have just never been put together and tested for real to leverage that understanding to its full potential
- (and the corollary - what if, even if we not are there yet, we are approaching the point where above will be true - eg in 5 or 10 or 15 years)
It likely will NOT be just one pill or therapy. And even the extend of the protocols on this forum are likely only giving us a decade or two extra vs what living a life based on our “mothers advice” would yield.
He also seems to believe there is some real probability that human kind might reach full longevity escape within either this or the next generation - and he’d really want to have a chance of being part of that.
In that context taking some risk that things in his protocol combined may shorten his life by say 5-10% (or do you think he is risking more than that?) might be worth it if he believes it might buy him even just a very, very small probability increase of intercepting longevity escape velocity and perhaps adding 100s or 1000s of % to his life span (and seeing a future that he seems to believe will be much better and have more powerful experiences than the present).
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Anything is possible but you are trying to thread a very fine needle. I just don’t have time to consider all the what ifs….maybe I’ll miss something important. I’ll keep watching.
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Neo
#266
Yes, that is the change in his rapa protocol that I mention in my original post.
My guess it that they are carefully looking at what his rapa blood levels will be at different points of peaks and valleys of this protocol.
And perhaps they actually do not want a complete washout. Most ITP results - rapa and other compounds - did not have any complete washout, but were more like chronic dosing I think? That is also the case with most CR studies which partially overlap mechanistically with rapa.
So Bryan/Oliver may actually not be targeting a complete exit from any trace level of rapa in his system, but may want some level do be there even in the valleys. Not sure we can really argue that that hypothesis is worse than a hypothesis that rapa should be fully washed out now and then?
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Neo
#267
Yes (but it’s not me, but rather a near billionaire with 30+ docs and other experts + basically unlimited ability to test all types of assays in a repeat way
I wonder how many other people are part of Oliver’s clients that are going aggressive - they are getting data from those people too).
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If he has no side effects from accumulation of rapa, then he only has to worry about unseen and unfelt side effects. I did get noticeable side effects (pimples, boils, mouth sores) when I did weekly dosing with no breaks.
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Neo
#269
Btw, given that we are discussing rapa a lot here, people may want to look at this big review that is just out:
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LaraPo
#270
I watched the interview, which I consider one of his best presentations of his agenda. He stated that he trusts nobody but the numbers and is about to launch another stage of his BP program by delivering food, supplements to our (consumers’) doors for us to just blindly consume it 3 times a day in hope to achieve what he has already achieved. It’s a kind of a cookie-cutter way to treat everybody with one size fits all approach. I don’t buy it. We are all different and what works for Bryan may not work for me. His bio parameters are measured, not mine, and mine are most likely different from his and therefore his designer formula may not benefit my needs. I had a feeling that he looks at us as a crowd with crowd mentality (reminds me Hitler’s approach) and he envisions himself as our leader who would guide us for survival and immortality. It’s a little laughable taking into consideration what is happening in the world right now. Just my 2 cents.
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Do you really think Oliver has any other clients? I suspect Bryan is pretty high maintenance and is likely his only client right now… Of course his plan is to expand.
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Neo
#272
Not sure that is a fair characterization. It seems that he is really trying to arrange so that several thousands of people do a lot of testing (blood work, ideally body composition/dexa, etc) and in that sense is putting the blueprint “light” components/product to the test and inviting scrutiny and objective data
See below and also @Paul_2.0 s post
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Neo
#273
Not sure. I know he was building this whole systematic set of framework with all the body sub-system measurement and optimization protocols for a while - and before BJ I think.
I’d imagine that there are other wealthy individuals that have reached out to him and want to do a version of the data rich, optimal protocol (and that they’d generally want to keep it private). But I’m just guessing.
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I don’t want to become an apologist for Bryan. I’d agree there’s a bit of a messianic tinge to some of his ideas, which I find a turn off.
I signed up for the blueprint protocol and was accepted, so I’ve been getting regular emails. I’m still not sure if I’m going to do it. Bryan’s team are trying to build some datasets from Blueprint. They’re tracking blood and body comp and sleep data. To my knowledge nobody has done this yet, and if there’s going to be any movement towards preventative interventions this type of thing has to start somewhere. If they can build a dataset of 2500 people and show that their protocol works great. The idea of collecting data on this site has been muted several times and it’s incredibly challenging. We don’t have to agree with Bryan to see the value in the exercise. One of the things I like about this forum, is there are a lot of people who don’t really follow the herd. Let’s face it, most people aren’t taking experimental drugs in the hope that it may extend their lifespan. The majority of people most likely never even think about it.
What I see here is a genuine attempt to quantify health span and try to build a framework, albeit a really basic one, that gives people a direction to take control of their health. One hundred percent agree that Bryan’s N of 1 is specifically tailored to Bryan, but there’s still value in an attempt.
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